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Sox10 Gene Detail
Summary
  • Symbol
    Sox10
  • Name
    SRY (sex determining region Y)-box 10
  • Synonyms
    gt, Sox21
  • Feature Type
    protein coding gene
  • IDs
    MGI:98358
    NCBI Gene: 20665
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79039113-79048690 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98358
 protein coding gene Chr15:79039108-79049440 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022067
 protein coding gene Chr15:79412083-79421651 (-)
A/J MGP_AJ_G0022028
 protein coding gene Chr15:76670274-76679879 (-)
AKR/J MGP_AKRJ_G0022003
 protein coding gene Chr15:78796045-78805650 (-)
BALB/cJ MGP_BALBcJ_G0022034
 protein coding gene Chr15:76642052-76651655 (-)
C3H/HeJ MGP_C3HHeJ_G0021805
 protein coding gene Chr15:78795633-78805237 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022477
 protein coding gene Chr15:82530999-82540572 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020007
 protein coding gene Chr15:73151250-73160616 (-)
CAST/EiJ MGP_CASTEiJ_G0021326
 protein coding gene Chr15:79493610-79503133 (-)
CBA/J MGP_CBAJ_G0021770
 protein coding gene Chr15:85082522-85092127 (-)
DBA/2J MGP_DBA2J_G0021899
 protein coding gene Chr15:76147843-76157448 (-)
FVB/NJ MGP_FVBNJ_G0021877
 protein coding gene Chr15:75172472-75182891 (-)
LP/J MGP_LPJ_G0021967
 protein coding gene Chr15:79602796-79612370 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021897
 protein coding gene Chr15:90232710-90242277 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022491
 protein coding gene Chr15:78818733-78828300 (-)
PWK/PhJ MGP_PWKPhJ_G0021068
 protein coding gene Chr15:76154943-76164610 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020905
 protein coding gene Chr15:78625035-78634464 (-)
WSB/EiJ MGP_WSBEiJ_G0021378
 protein coding gene Chr15:79201860-79211435 (-)



Homology
more
  • Human Ortholog
    SOX10, SRY-box transcription factor 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX10, SRY-box transcription factor 10
  • Synonyms
    DOM, PCWH, SOX-10, WS2E, WS4, WS4C
  • Links
    NCBI Gene ID: 6663
    neXtProt AC: NX_P56693
    UniProt: P56693

  • Chr Location
    22q13.1; chr22:37970686-37987422 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Sox10 mouse models; 4 with human SOX10 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    100 phenotypes from 14 alleles in 23 genetic backgrounds
    40 phenotypes from multigenic genotypes
    7 images
    157 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations lack peripheral glial cells, melanocytes, and autonomic and enteric neurons, and die neonatally or sooner. Heterozygotes exhibit white spotting and megacolon.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    80
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2565
  • Tissues
    586
  • cDNA Data
    173
  • Literature Summary
    585
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20665 NCBI Gene Model | MGI Sequence Detail 9578 C57BL/6J ±  kb
    transcript NM_011437 RefSeq | MGI Sequence Detail 2713 ZRU/MplStud  
    polypeptide Q04888 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 239
      Genomic 7
      cDNA 179
      Primer pair 14
      Other 39

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10325, MGD-MRK-14497, MGD-MRK-38228, MGD-MRK-8879, MGI:109184, MGI:94914, MGI:95866
    References
    more
    • Summaries
      All 746
      Developmental Gene Expression 585
      Diseases 4
      Gene Ontology 24
      Phenotypes 157
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345613 Nikoloudaki G, et al., Assessing the fate and contribution of Foxd1-expressing embryonic precursors and their progeny in palatal development, homeostasis and excisional repair. Sci Rep. 2024 Feb 29;14(1):4969
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory