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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Braf
Braf transforming gene
MGI:88190
52 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Braftm1.1Brd/Braf+
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Tg(Vil1-cre)997Gum/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL 		increased carcinoma incidence J:199307
increased intestinal adenoma incidence J:199307
Braftm1.1Brd/Braf+
Tg(Vil1-cre)997Gum/0
Trp53tm2Tyj/Trp53tm2Tyj
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal tumor pathology J:199307
increased metastatic potential J:199307
Braftm1Cpri/Braf+
Grprtm1Jfb/?
Scn10atm2(cre)Jwo/Scn10a+
involves: 129 * 129P2/OlaHsd * 129X1/SvJ 		normal behavior/neurological phenotype J:205122
Braftm1Cpri/Braf+
Grptm1Jfb/Grptm1Jfb
Scn10atm2(cre)Jwo/Scn10a+
involves: 129 * 129P2/OlaHsd * 129X1/SvJ * C57BL/6J 		normal behavior/neurological phenotype J:205122
Braftm1Cpri/Braftm1Cpri
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(Tyr-cre/ERT2)1Lru/0
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL 		increased incidence of tumors by chemical induction J:147434
increased melanoma incidence J:147434
increased skin tumor incidence J:147434
Braftm1Cpri/Braftm1Cpri
Gnastm3Lsw/Gnastm3Lsw
Tg(TPO-cre)1Shk/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr 		increased thyroid tumor incidence J:168249
Braftm1Cpri/Braftm1Cpri
Tshrtm1Rmar/Tshrtm1Rmar
Tg(TPO-cre)1Shk/0
involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr 		abnormal thyroid follicle morphology J:168249
increased thyroid tumor incidence J:168249
small thyroid gland J:168249
Braftm1Mmcm/Braf+
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd 		abnormal lung morphology J:121715
increased lung adenocarcinoma incidence J:121715
increased lung tumor incidence J:121715
Braftm1Mmcm/Braf+
Trp53tm1Brn/Trp53tm3.1Tyj
Tg(TPO-cre/ERT2)1139Tyj/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac 		increased thyroid carcinoma incidence J:208854
Braftm1Mmcm/Braf+
Ptentm1Mro/Ptentm1Mro
Tg(Tyr-cre/ERT2)1Lru/0
B6.Cg-Braftm1Mmcm Tg(Tyr-cre/ERT2)1Lru Ptentm1Mro 		decreased tumor-free survival time J:188523
increased cutaneous melanoma incidence J:188523
premature death J:188523
spontaneous skin ulceration J:188523
Braftm1Mmcm/Braf+
Ptentm2.1Ppp/Pten+
Tg(Tyr-cre/ERT2)13Bos/0
involves: 129P2/OlaHsd * 129S1/Sv * FVB 		abnormal melanocyte morphology J:151023
increased cutaneous melanoma incidence J:151023
Braftm1Mmcm/Braf+
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Tyr-cre/ERT2)13Bos/0
involves: 129P2/OlaHsd * 129S1/Sv * FVB 		increased cutaneous melanoma incidence J:151023
increased metastatic potential J:151023
Braftm1Mmcm/Braf+
Cdkn2atm4Rdp/Cdkn2atm4Rdp
involves: 129P2/OlaHsd 		increased lung tumor incidence J:121715
Braftm1Mmcm/Braf+
Trp53tm3.1Tyj/Trp53+
Tg(TPO-cre/ERT2)1139Tyj/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac 		increased thyroid carcinoma incidence J:208854
premature death J:208854
Braftm1Mmcm/Braf+
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Mitf-cre)7114Gsb/0
STOCK Braftm1Mmcm Gt(ROSA)26Sortm14(CAG-tdTomato)Hze Tg(Mitf-cre)7114Gsb/Cvrk 		abnormal cell physiology J:312561
increased tail pigmentation J:312561
Braftm1Mmcm/Braf+
Ptentm1Rdp/Ptentm1Rdp
Tg(Tyr-cre/ERT2)13Bos/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N 		increased cutaneous melanoma incidence J:151023
increased metastatic potential J:151023
Braftm1Mmcm/Braf+
Tg(TPO-cre/ERT2)1139Tyj/0
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac 		decreased tumor-free survival time J:208854
increased metastatic potential J:208854
increased thyroid carcinoma incidence J:208854
increased thyroid-stimulating hormone level J:208854
respiratory failure J:208854
Braftm1Mmcm/Braf+
Ezh2tm1.1Nesh/Ezh2+
Tg(Tyr-cre/ERT2)13Bos/0
involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB 		increased melanoma incidence J:239472
Braftm1Mmcm/Braftm1Mmcm
Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+
Ptentm1Hwu/Pten+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		increased metastatic potential J:191327
increased prostate gland adenocarcinoma incidence J:191327
increased prostate gland tumor incidence J:191327
increased prostate intraepithelial neoplasia incidence J:191327
premature death J:191327
Braftm1Rima/Braf+
Tg(GFP/KRAS2/ALPP)1Brn/0
Tg(Tyr-cre/ERT2)1Lru/0
involves: C57BL/6 * DBA/2 * FVB/N 		increased melanoma incidence J:161180
Braftm1Rima/Braf+
Krastm4Tyj/Kras+
Tg(Tyr-cre/ERT2)1Lru/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 		hyperpigmentation J:161180
increased tumor incidence J:161180
Braftm1Sva/Braf+
Raf1tm2Bacc/Raf1tm2Bacc
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		no abnormal phenotype detected J:121660
Braftm1Sva/Braftm1.1Sva
Raf1tm1Bacc/Raf1tm2Bacc
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal axon extension J:121660
abnormal dorsal root ganglion morphology J:121660
abnormal innervation J:121660
embryonic lethality during organogenesis, complete penetrance J:121660
Braftm1Sva/Braftm1Sva
Krastm1Bbd/Kras+
involves: 129S1/Sv * 129X1/SvJ 		increased lung non-small cell carcinoma incidence J:172200
premature death J:172200
Braftm1Sva/Braftm1Sva
Krastm1Bbd/Kras+
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
involves: 129S1/Sv * 129X1/SvJ 		decreased cell proliferation J:172200
Braftm1Sva/Braftm1Sva
Krastm1Bbd/Kras+
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Raf1tm2Bacc/Raf1tm2Bacc
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		decreased cell proliferation J:172200
Braftm1Sva/Braftm1Sva
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Raf1tm2Bacc/Raf1tm2Bacc
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:172200
Braftm1Sva/Braftm1Sva
Raf1tm2Bacc/Raf1+
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal dorsal root ganglion morphology J:121660
abnormal innervation J:121660
abnormal sensory neuron innervation pattern J:121660
postnatal growth retardation J:121660
postnatal lethality, incomplete penetrance J:121660
Braftm1Sva/Braftm1Sva
Raf1tm2Bacc/Raf1tm2Bacc
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal axon extension J:121660
Braftm1Tuv/Braftm1Tuv
Gt(ROSA)26Sortm1(sb13)Tuv/Gt(ROSA)26Sor+
Tg(Tyr-cre/ERT2)13Bos/0
TgTn(sb-T2/Onc)#Dla/0
involves: 129S6/SvEvTac * FVB/N 		increased melanoma incidence J:177503
Braftm1Wds/Braf+
Raf1tm2Bacc/Raf1tm2Bacc
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		no abnormal phenotype detected J:121660
Braftm1Wds/Braftm1.1Wds
Raf1tm1Bacc/Raf1tm2Bacc
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal axon extension J:121660
abnormal dorsal root ganglion morphology J:121660
abnormal innervation J:121660
embryonic lethality during organogenesis, complete penetrance J:121660
Braftm1Wds/Braftm1Wds
Raf1tm2Bacc/Raf1+
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal dorsal root ganglion morphology J:121660
abnormal innervation J:121660
abnormal sensory neuron innervation pattern J:121660
postnatal growth retardation J:121660
postnatal lethality, incomplete penetrance J:121660
Braftm1Wds/Braftm1Wds
Raf1tm2Bacc/Raf1tm2Bacc
involves: 129P2/OlaHsd * C57BL/6 		abnormal axon extension J:121660
Braftm1Wds/Braftm1Wds
Raf1tm2Bacc/Raf1tm2Bacc
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * C57BL/6J * CBA/J 		abnormal conotruncus morphology J:144862
abnormal thyroid gland morphology J:144862
double outlet right ventricle J:144862
normal growth/size/body region phenotype J:144862
normal hearing/vestibular/ear phenotype J:144862
lethality throughout fetal growth and development, complete penetrance J:144862
mandible hypoplasia J:144862
persistent truncus arteriosus J:144862
short maxilla J:144862
small thymus J:144862
small thyroid gland J:144862
ventricular septal defect J:144862
Braftm2Cpri/Braf+
Krastm4Tyj/Kras+
involves: 129S4/SvJae * C57BL/6 		increased fibroblast proliferation J:187371
increased lung adenoma incidence J:187371
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory