115 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Adam17tm1.1Wesh/Adam17tm1.1Wesh Tg(Scgb1a1-rtTA)2Jaw/0 Tg(tetO-cre)1Jaw/0 Twist2tm1.1(cre)Dor/Twist2+ involves: 129X1/SvJ * C57BL/6 * FVB/N	abnormal lung saccule morphology	J:210193
	abnormal lung vasculature morphology	J:210193
	decreased cell proliferation	J:210193
	normal mortality/aging	J:210193
Adam17tm1.1Wesh/Adam17tm1.1Wesh Twist2tm1.1(cre)Dor/Twist2+ involves: 129X1/SvJ * C57BL/6 * FVB/N	normal respiratory system phenotype	J:210193
ApcMin/Apc+ Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl Twist2tm1.1(cre)Dor/Twist2+ involves: 129X1/SvJ * BALB/cJ * C57BL/6J	decreased tumor growth/size	J:262876
	decreased tumor incidence	J:262876
Ctnna1tm1Efu/Ctnna1tm1Efu Twist2tm1(cre)Dor/Twist2+ involves: 129X1/SvJ	abnormal skeleton development	J:178499
	decreased width of hypertrophic chondrocyte zone	J:178499
	delayed intramembranous bone ossification	J:178499
Ctnnb1tm1Yy/Ctnnb1tm1Yy Twist2tm1(cre)Dor/Twist2+ involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6	fused synovial joints	J:93028
Ctnnb1tm2Kem/Ctnnb1tm2Kem Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	abnormal bone structure	J:178499
	abnormal cartilage morphology	J:178499
	abnormal joint morphology	J:178499
	abnormal skeleton morphology	J:178499
	arrested osteoblast differentiation	J:178499
	ectopic cartilage	J:178499
	failure of bone ossification	J:178499
	split sternum	J:178499
Epha4tm1.1Bzh/Epha4tm1.1Bzh Tg(Hlxb9-GFP)1Tmj/0 Twist2tm1(cre)Dor/Twist2+ involves: 129S/Sv * C57BL/6J * CD-1 * FVB/N	abnormal innervation	J:243785
Fgf10tm1Ska/Fgf10tm1Sms Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA	abnormal lung development	J:150706
	abnormal lung lobe morphology	J:150706
	abnormal right lung accessory lobe morphology	J:150706
	abnormal right lung cranial lobe morphology	J:150706
	abnormal right lung middle lobe morphology	J:150706
	impaired branching involved in bronchus morphogenesis	J:150706
	lung hemorrhage	J:150706
	pulmonary hypoplasia	J:150706
	small lung	J:150706
	small lung lobe	J:150706
Fgfr1tm1Jpa/Fgfr1+ Fgfr2tm1Dor/Fgfr2tm1.1Dor Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal small intestine morphology	J:139005
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa Fgfr2tm1Dor/Fgfr2+ Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal small intestine morphology	J:139005
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa Fgfr2tm1Dor/Fgfr2tm1.1Dor Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal digestive system physiology	J:139005
	abnormal small intestine crypts of Lieberkuhn morphology	J:139005
	abnormal small intestine morphology	J:139005
Fgfr1tm1Jpa/Fgfr1tm1Jpa Fgfr2tm1Dor/Fgfr2tm1Dor Twist2tm1.1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	abnormal reproductive system physiology	J:223057
	genital tubercle hypoplasia	J:223057
Fgfr2tm1Dor/Fgfr2tm1.1Dor Twist2tm1(cre)Dor/Twist2+ involves: 129X1/SvJ	abnormal appendicular skeleton morphology	J:90391
	abnormal axial skeleton morphology	J:90391
	abnormal cervical vertebrae morphology	J:90391
	abnormal joint morphology	J:90391
	abnormal long bone hypertrophic chondrocyte zone	J:90391
	abnormal long bone metaphysis morphology	J:90391
	abnormal osteoblast physiology	J:90391
	abnormal osteoclast differentiation	J:90391
	abnormal skeleton development	J:90391
	abnormal thoracic vertebrae morphology	J:90391
	abnormal vertebrae development	J:90391
	abnormal vertebrae morphology	J:90391
	absent vertebral spinous process	J:90391
	decreased bone mineral density	J:90391
	decreased cell proliferation	J:90391
	decreased osteoblast cell number	J:90391
	disproportionate dwarf	J:90391
	domed cranium	J:90391
	postnatal growth retardation	J:90391
	short femur	J:90391
Hdac8tm1.1Eno/Y Twist2tm1(cre)Dor/Twist2+ involves: 129 * C57BL/6 * CD-1 * SJL	no abnormal phenotype detected	J:150709
Kdrtm1Jrt/Kdr+ Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu	abnormal lung morphology	J:192736
	abnormal vasculogenesis	J:192736
Lrp5tm1.1Vari/Lrp5tm1.1Vari Lrp6tm1.1Vari/Lrp6tm1.1Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	abnormal bone ossification	J:178499
	abnormal bone structure	J:178499
	abnormal cartilage morphology	J:178499
	abnormal cranium morphology	J:178499
	abnormal epiphyseal plate morphology	J:178499
	abnormal limb morphology	J:178499
	abnormal skeleton morphology	J:178499
	abnormal trabecular bone morphology	J:178499
	decreased body size	J:178499
	ectopic cartilage	J:178499
	neonatal lethality, complete penetrance	J:178499
	split sternum	J:178499
Lrp5tm1.1Vari/Lrp5tm1.2Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	normal skeleton phenotype	J:178499
Lrp5tm1.2Vari/Lrp5tm1.2Vari Lrp6tm1.1Vari/Lrp6tm1.1Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	abnormal bone ossification	J:178499
	abnormal bone structure	J:178499
	abnormal cartilage morphology	J:178499
	abnormal cranium morphology	J:178499
	abnormal epiphyseal plate morphology	J:178499
	abnormal joint morphology	J:178499
	abnormal limb morphology	J:178499
	abnormal osteoblast differentiation	J:178499
	abnormal skeleton morphology	J:178499
	abnormal trabecular bone morphology	J:178499
	decreased body size	J:178499
	decreased width of hypertrophic chondrocyte zone	J:178499
	ectopic cartilage	J:178499
	failure of bone ossification	J:178499
	neonatal lethality, complete penetrance	J:178499
	split sternum	J:178499
Lrp6tm1.1Vari/Lrp6tm1.1Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	delayed bone ossification	J:178499
	normal skeleton phenotype	J:178499
Lrp6tm1.1Vari/Lrp6tm1.2Vari Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	delayed bone ossification	J:178499
	normal skeleton phenotype	J:178499
Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl Twist2tm1.1(cre)Dor/Twist2+ involves: 129X1/SvJ * BALB/cJ * C57BL/6	decreased incidence of tumors by chemical induction	J:262876
Mef2ctm1Eno/Mef2ctm2Eno Twist2tm1(cre)Dor/Twist2+ involves: 129S/SvEv * 129S7/SvEvBrd * 129X1/SvJ	abnormal endochondral bone ossification	J:119152
	abnormal trabecular bone morphology	J:119152
	failure of endochondral bone ossification	J:119152
	postnatal lethality, complete penetrance	J:119152
	respiratory distress	J:119152
	short fibula	J:119152
	short limbs	J:119152
	short tibia	J:119152
Mirc32tm1.1Jtm/Mirc32tm1.1Jtm Twist2tm1(cre)Dor/Twist2+ B6.129(Cg)-Twist2tm1.1(cre)Dor Mirc32tm1.1Jtm	abnormal colon morphology	J:214382
	abnormal intestinal mucosa morphology	J:214382
	abnormal large intestine crypts of Lieberkuhn morphology	J:214382
	abnormal susceptibility to induced morbidity/mortality	J:214382
	colonic necrosis	J:214382
	impaired intestine regeneration	J:214382
	increased susceptibility to induced colitis	J:214382
	intestinal ulcer	J:214382
Mmp14tm1Stjw/Mmp14tm1Stjw Twist2tm1.1(cre)Dor/Twist2+ involves: 129X1/SvJ * C57BL/6	abnormal bone ossification	J:198679
	abnormal cartilage morphology	J:198679
	abnormal hypodermis fat layer morphology	J:198679
	abnormal joint morphology	J:198679
	decreased body size	J:198679
	decreased body weight	J:198679
	decreased bone mineral density	J:198679
	delayed cranial suture closure	J:198679
	delayed intramembranous bone ossification	J:198679
	domed cranium	J:198679
	increased bone marrow adipose tissue amount	J:198679
	postnatal growth retardation	J:198679
	premature death	J:198679
	short snout	J:198679
	normal skeleton phenotype	J:198679
Nfibtm2Rmg/Nfibtm2Rmg Twist2tm1(cre)Dor/Twist2+ involves: 129S4/SvJae * 129X1/SvJ * C57BL/6	abnormal lung development	J:173651
	abnormal lung morphology	J:173651
	abnormal lung saccule morphology	J:173651
	abnormal respiratory system physiology	J:173651
	enlarged lung	J:173651
	perinatal lethality, complete penetrance	J:173651
Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu	abnormal lung development	J:192736
	abnormal lung morphology	J:192736
	abnormal lung vasculature morphology	J:192736
	abnormal lung-associated mesenchyme development	J:192736
	abnormal vascular development	J:192736
	cyanosis	J:192736
	decreased blood oxygen capacity	J:192736
	hemorrhage	J:192736
	lethality throughout fetal growth and development, incomplete penetrance	J:192736
	neonatal lethality, complete penetrance	J:192736
	respiratory distress	J:192736
Ptpratm1c(EUCOMM)Hmgu/Ptpratm1c(EUCOMM)Hmgu Twist2tm1.1(cre)Dor/Twist2+ involves: 129X1/SvJ * C57BL/6N	decreased susceptibility to injury	J:300194
Robo1tm1Matl/Robo1tm1Matl Robo2tm1Rilm/Robo2tm1Rilm Twist2tm1(cre)Dor/Twist2+ involves: 129 * 129X1/SvJ	abnormal foregut morphology	J:193400
	diaphragmatic hernia	J:193400
	neonatal lethality	J:193400
	respiratory failure	J:193400
	small esophagus	J:193400
Runx2tm1Mjo/Runx2+ Twist2tm1(cre)Dor/Twist2+ involves: 129X1/SvJ * C57BL/6	clavicle hypoplasia	J:90056
Runx2tm1Mjo/Runx2+ Twist2tm1(cre)Dor/Twist2tm1(cre)Dor involves: 129X1/SvJ * C57BL/6	delayed fontanelle closure	J:90056
	normal skeleton phenotype	J:90056
	small interparietal bone	J:90056
Snai1tm1.1Stjw/Snai1tm1.1Stjw Twist2tm1.1(cre)Dor/Twist2+ B6.129(SJL)-Twist2tm1.1(cre)Dor Snai1tm1.1Stjw	no abnormal phenotype detected	J:214991
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm Twist2tm1(cre)Dor/Twist2+ involves: 129X1/SvJ * C57BL/6	abnormal branching involved in lung morphogenesis	J:143910
	abnormal bronchial cartilage morphology	J:143910
	abnormal bronchus morphology	J:143910
	abnormal lung lobe morphology	J:143910
	abnormal tracheal cartilage morphology	J:143910
	decreased tracheal cartilage ring number	J:143910
	dilated respiratory conducting tube	J:143910
	lethality throughout fetal growth and development, complete penetrance	J:143910
Twist1tm1Bhr/Twist1+ Twist2tm1(cre)Dor/Twist2+ involves: 129/Sv * 129X1/SvJ	abnormal skeletal muscle morphology	J:81485
	cachexia	J:81485
	neonatal lethality, incomplete penetrance	J:81485
Twist2tm1(cre)Dor/Twist2+ Wnt7btm1Parr/Wnt7btm2Amc involves: 129S1/Sv * 129X1/SvJ	abnormal bone ossification	J:117333
	abnormal osteoblast differentiation	J:117333
	decreased width of hypertrophic chondrocyte zone	J:117333