Lrp6^tm1.1Vari
Targeted Allele Detail

Summary

• Symbol: Lrp6^tm1.1Vari
• Name: low density lipoprotein receptor-related protein 6; targeted mutation 1.1, van Andel Research Institute
• MGI ID: MGI:5299216
• Synonyms: Lrp6^f
• Gene: Lrp6 Location: Chr6:134423439-134543876 bp, - strand Genetic Position: Chr6, 65.37 cM
• Alliance: Lrp6^tm1.1Vari page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178499
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:178499, J:179033)

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp6 Mutation: 95 strains or lines available

References

• Original: J:178499 Joeng KS, et al., Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo. Dev Biol. 2011 Nov 15;359(2):222-9
• All: 34 reference(s)