All Phenotypes Lrp6<tm1.1Vari> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lrp6^tm1.1Vari
targeted mutation 1.1, van Andel Research Institute
MGI:5299216

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp6^tm1.1Vari/Lrp6^tm1.1Vari	involves: 129S1/Sv	MGI:5299317
cn2	Lrp6^tm1.1Vari/Lrp6^tm1.1Vari Twist2^tm1(cre)Dor/Twist2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5299320
cn3	Lrp6^tm1.1Vari/Lrp6^tm1.2Vari Twist2^tm1(cre)Dor/Twist2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5299321
cn4	Lrp5^tm1.1Vari/Lrp5^tm1.1Vari Lrp6^tm1.1Vari/Lrp6^tm1.1Vari Twist2^tm1(cre)Dor/Twist2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5299323
cn5	Lrp5^tm1.2Vari/Lrp5^tm1.2Vari Lrp6^tm1.1Vari/Lrp6^tm1.1Vari Twist2^tm1(cre)Dor/Twist2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5299324

Allelic Composition	Lrp6^tm1.1Vari/Lrp6^tm1.1Vari
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^tm1.1Vari mutation (1 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:178499 )

• mice develop and reproduce normally

Allelic Composition	Lrp6^tm1.1Vari/Lrp6^tm1.1Vari Twist2^tm1(cre)Dor/Twist2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^tm1.1Vari mutation (1 available); any Lrp6 mutation (95 available)
Twist2^tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:178499 )

N	• mice exhibit relatively normal skeleton

delayed bone ossification ( J:178499 )

• at E17.5, mice exhibit a slight delay in ossification of the skull compared with control mice

Allelic Composition	Lrp6^tm1.1Vari/Lrp6^tm1.2Vari Twist2^tm1(cre)Dor/Twist2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^tm1.1Vari mutation (1 available); any Lrp6 mutation (95 available)
Lrp6^tm1.2Vari mutation (0 available); any Lrp6 mutation (95 available)
Twist2^tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:178499 )

N	• mice exhibit relatively normal skeleton

delayed bone ossification ( J:178499 )

• at E17.5, mice exhibit a slight delay in ossification of the skull compared with control mice

Allelic Composition	Lrp5^tm1.1Vari/Lrp5^tm1.1Vari Lrp6^tm1.1Vari/Lrp6^tm1.1Vari Twist2^tm1(cre)Dor/Twist2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm1.1Vari mutation (1 available); any Lrp5 mutation (81 available)
Lrp6^tm1.1Vari mutation (1 available); any Lrp6 mutation (95 available)
Twist2^tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:178499 )

• mice die shortly after birth

skeleton

abnormal skeleton morphology ( J:178499 )

• all skeletal elements are shortened

abnormal cranium morphology ( J:178499 )

split sternum ( J:178499 )

abnormal bone structure ( J:178499 )

• mice exhibit partial bone collar

abnormal trabecular bone morphology ( J:178499 )

• absent

abnormal cartilage morphology ( J:178499 )

• mice exhibit extra cartilage elements (typically 4) in the zeugopod and in some autopods

ectopic cartilage ( J:178499 )

• at the diaphysis

abnormal epiphyseal plate morphology ( J:178499 )

abnormal bone ossification ( J:178499 )

• profound defect in ossification of the craniofacial, the rest of the axial, and the appendicular skeleton

• partial ossification of the scapula and ileum

• however, some ossification of zeugopod elements and other skeletal elements is observed

growth/size/body

decreased body size ( J:178499 )

limbs/digits/tail

abnormal limb morphology ( J:178499 )

craniofacial

abnormal cranium morphology ( J:178499 )

Allelic Composition	Lrp5^tm1.2Vari/Lrp5^tm1.2Vari Lrp6^tm1.1Vari/Lrp6^tm1.1Vari Twist2^tm1(cre)Dor/Twist2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^tm1.2Vari mutation (0 available); any Lrp5 mutation (81 available)
Lrp6^tm1.1Vari mutation (1 available); any Lrp6 mutation (95 available)
Twist2^tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:178499 )

• mice die shortly after birth

skeleton

abnormal skeleton morphology ( J:178499 )

• all skeletal elements are shortened

abnormal cranium morphology ( J:178499 )

split sternum ( J:178499 )

abnormal bone structure ( J:178499 )

• mice exhibit partial bone collar

abnormal osteoblast differentiation ( J:178499 )

• mature osteoblasts fail to form

abnormal trabecular bone morphology ( J:178499 )

• absent

abnormal cartilage morphology ( J:178499 )

• mice exhibit extra cartilage elements (typically 4) in the zeugopod and in some autopods

ectopic cartilage ( J:178499 )

• at the diaphysis and surrounding the marrow cavity

abnormal joint morphology ( J:178499 )

• mice lack joints at multiple locations including the knees

abnormal epiphyseal plate morphology ( J:178499 )

decreased width of hypertrophic chondrocyte zone ( J:178499 )

• at E14.5, mice exhibit a delay in chondrocyte hypertrophy

abnormal bone ossification ( J:178499 )

• profound defect in ossification of the craniofacial, the rest of the axial, and the appendicular skeleton

• partial ossification of the scapula and ileum

failure of bone ossification ( J:178499 )

• except for the scapula and ileum

growth/size/body

decreased body size ( J:178499 )

cellular

abnormal osteoblast differentiation ( J:178499 )

• mature osteoblasts fail to form

limbs/digits/tail

abnormal limb morphology ( J:178499 )

• mice exhibit an additional element bridging the zeugopod and stylopod

craniofacial

abnormal cranium morphology ( J:178499 )

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