Lrp5^tm1.2Vari
Targeted Allele Detail

Summary

• Symbol: Lrp5^tm1.2Vari
• Name: low density lipoprotein receptor-related protein 5; targeted mutation 1.2, van Andel Research Institute
• MGI ID: MGI:5299217
• Synonyms: Lrp5ⁿ
• Gene: Lrp5 Location: Chr19:3634828-3736564 bp, - strand Genetic Position: Chr19, 3.33 cM, cytoband B
• Alliance: Lrp5^tm1.2Vari page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178499
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 2 from Lrp5^tm1.1Flng. (J:178499, J:179033)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp5 Mutation: 81 strains or lines available

References

• Original: J:178499 Joeng KS, et al., Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo. Dev Biol. 2011 Nov 15;359(2):222-9
• All: 4 reference(s)