Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tsc2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes TSC2
- Mouse genes Tsc2
- Rat genes Tsc2
- Zfish genes tsc2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tsc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	Tsc2	IDA		Mouse	PMID:18198340
Molecular Function	GO:0005096	GTPase activator activity	TSC2	IDA		Human	PMID:9045618
Molecular Function	GO:0005096	GTPase activator activity	Tsc2	IDA		Rat	PMID:12869586\|RGD:1580520
Molecular Function	GO:0051879	Hsp90 protein binding	TSC2	IPI	UniProtKB:P07900,UniProtKB:Q92574	Human	PMID:29127155
Molecular Function	GO:0019902	phosphatase binding	TSC2	IDA		Human	PMID:19389623
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q92574	Human	PMID:10585443
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P63104	Human	PMID:12176984
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P61981	Human	PMID:12364343
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P31946	Human	PMID:12582162
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P63104	Human	PMID:16636147
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q92574	Human	PMID:17693255
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q969U6	Human	PMID:18381890
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P58004	Human	PMID:18692468
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P62136	Human	PMID:19389623
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P31946	Human	PMID:20169078
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q96EB6	Human	PMID:20169165
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q92574	Human	PMID:20412061
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P63104	Human	PMID:20618440
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q92574	Human	PMID:21134130
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q9NRD5	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P31946	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q92574	Human	PMID:25263562
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:O00141	Human	PMID:27451907
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:O94763	Human	PMID:28561026
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q9H6T3	Human	PMID:28561026
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:P61981	Human	PMID:33473107
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q92574	Human	PMID:9580671
Molecular Function	GO:0005515	protein binding	TSC2	IPI	UniProtKB:Q92574	Human	PMID:9809973
Molecular Function	GO:0005515	protein binding	Tsc2	IPI	UniProtKB:Q9EP53	Mouse	MGI:MGI:6092779\|PMID:28671696
Molecular Function	GO:0005515	protein binding	Tsc2	IPI	UniProtKB:Q9EP53	Mouse	MGI:MGI:5508563\|PMID:20412061
Molecular Function	GO:0005515	protein binding	Tsc2	IPI	UniProtKB:P58043	Mouse	MGI:MGI:3808916\|PMID:18692468
Molecular Function	GO:0005515	protein binding	Tsc2	IPI	PR:Q9EP53	Mouse	PMID:11741832
Molecular Function	GO:0005515	protein binding	Tsc2	IPI	RGD:1312048	Rat	PMID:14559897\|RGD:1304444
Molecular Function	GO:0005515	protein binding	Tsc2	IPI	RGD:1346664	Rat	PMID:9045618\|RGD:11568652
Molecular Function	GO:0042803	protein homodimerization activity	TSC2	IPI	UniProtKB:P49815	Human	PMID:10585443
Molecular Function	GO:0044877	protein-containing complex binding	Tsc2	IPI	RGD:736947	Rat	PMID:15093748\|RGD:1580491
Molecular Function	GO:0031267	small GTPase binding	TSC2	IPI	UniProtKB:Q7L523	Human	PMID:25936802
Cellular Component	GO:0005901	caveola	Tsc2	IDA		Rat	PMID:15093748\|RGD:1580491
Cellular Component	GO:0042995	cell projection	Tsc2	IDA		Rat	PMID:17376623\|RGD:11568689
Cellular Component	GO:0005737	cytoplasm	TSC2	IDA		Human	PMID:17114346
Cellular Component	GO:0005737	cytoplasm	TSC2	IDA		Human	PMID:16636147
Cellular Component	GO:0005737	cytoplasm	TSC2	IDA		Human	PMID:9580671
Cellular Component	GO:0005737	cytoplasm	Tsc2	IDA		Mouse	PMID:11741832
Cellular Component	GO:0005856	cytoskeleton	Tsc2	IDA		Rat	PMID:12147258\|RGD:1601407
Cellular Component	GO:0005829	cytosol	TSC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	TSC2	IDA		Human	PMID:10585443
Cellular Component	GO:0005829	cytosol	Tsc2	IDA		Rat	PMID:12147258\|RGD:1601407
Cellular Component	GO:0030425	dendrite	Tsc2	IDA		Rat	PMID:15525761\|RGD:2307416
Cellular Component	GO:0098978	glutamatergic synapse	Tsc2	IDA		Rat	PMID:24889507\|RGD:13702223
Cellular Component	GO:0098978	glutamatergic synapse	Tsc2	IMP		Rat	PMID:24889507\|RGD:13702223
Cellular Component	GO:0005794	Golgi apparatus	TSC2	IDA		Human	PMID:8806680
Cellular Component	GO:0030426	growth cone	Tsc2	IDA		Rat	PMID:14559897\|RGD:1304444
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Tsc2	IDA		Rat	PMID:12147258\|RGD:1601407
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Tsc2	IDA		Rat	PMID:15093748\|RGD:1580491
Cellular Component	GO:0005764	lysosome	TSC2	IDA		Human	PMID:25936802
Cellular Component	GO:0016020	membrane	TSC2	IDA		Human	PMID:16636147
Cellular Component	GO:0045121	membrane raft	Tsc2	IDA		Rat	PMID:15093748\|RGD:1580491
Cellular Component	GO:0043005	neuron projection	Tsc2	IDA		Rat	PMID:14559897\|RGD:1304444
Cellular Component	GO:0043025	neuronal cell body	Tsc2	IDA		Rat	PMID:15525761\|RGD:2307416
Cellular Component	GO:0005634	nucleus	TSC2	IDA		Human	PMID:17114346
Cellular Component	GO:0048471	perinuclear region of cytoplasm	TSC2	IDA		Human	PMID:8806680
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Tsc2	IDA		Rat	PMID:14559897\|RGD:1304444
Cellular Component	GO:0014069	postsynaptic density	TSC2	EXP		Human	PMID:27898073
Cellular Component	GO:0014069	postsynaptic density	TSC2	IDA		Human	PMID:27898073
Cellular Component	GO:0045202	synapse	Tsc2	EXP		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Tsc2	IDA		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Tsc2	EXP		Mouse	PMID:16452087
Cellular Component	GO:0045202	synapse	Tsc2	IDA		Mouse	PMID:16452087
Cellular Component	GO:0033596	TSC1-TSC2 complex	TSC2	IPI		Human	PMID:22795129
Cellular Component	GO:0033596	TSC1-TSC2 complex	TSC2	IDA		Human	PMID:9580671
Biological Process	GO:0007568	aging	Tsc2	IDA		Rat	PMID:20818934\|RGD:12880377
Biological Process	GO:0043276	anoikis	TSC2	IGI	UniProtKB:Q61037	Human	PMID:23778976
Biological Process	GO:0043276	anoikis	Tsc2	IMP		Mouse	MGI:MGI:5819337\|PMID:23778976
Biological Process	GO:0042100	B cell proliferation	Tsc2	IGI	MGI:MGI:109583	Mouse	PMID:16027169
Biological Process	GO:0008283	cell population proliferation	Tsc2	IMP	MGI:MGI:1926345	Mouse	PMID:10096549
Biological Process	GO:0008283	cell population proliferation	Tsc2	IMP	MGI:MGI:1857938	Mouse	PMID:10491404
Biological Process	GO:0008283	cell population proliferation	Tsc2	IGI	MGI:MGI:109583	Mouse	PMID:16027168
Biological Process	GO:0008283	cell population proliferation	Tsc2	IGI	MGI:MGI:109583	Mouse	PMID:16027169
Biological Process	GO:0030030	cell projection organization	Tsc2	IGI	UniProtKB:P42346	Rat	PMID:16286931\|RGD:8554187
Biological Process	GO:0030030	cell projection organization	Tsc2	IMP		Rat	PMID:16286931\|RGD:8554187
Biological Process	GO:0032869	cellular response to insulin stimulus	Tsc2	IMP		Mouse	PMID:18511518
Biological Process	GO:0030010	establishment of cell polarity	Tsc2	IMP		Rat	PMID:20530489\|RGD:11568685
Biological Process	GO:0045184	establishment of protein localization	Tsc2	IMP		Rat	PMID:15093748\|RGD:1580491
Biological Process	GO:0098976	excitatory chemical synaptic transmission	Tsc2	IMP	MGI:MGI:1857938	Mouse	PMID:30679017
Biological Process	GO:0046323	glucose import	Tsc2	IMP		Mouse	PMID:18511518
Biological Process	GO:0007507	heart development	Tsc2	IMP	MGI:MGI:1926345	Mouse	PMID:10096549
Biological Process	GO:0098977	inhibitory chemical synaptic transmission	Tsc2	IMP	MGI:MGI:1857938	Mouse	PMID:30679017
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Tsc2	IMP		Mouse	PMID:15249583
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Tsc2	IGI	MGI:MGI:1927343	Mouse	PMID:15249583
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Tsc2	IGI	MGI:MGI:1270849	Mouse	PMID:15249583
Biological Process	GO:0060575	intestinal epithelial cell differentiation	tsc2	IMP	ZFIN:ZDB-MRPHLNO-101117-8	Zfish	PMID:20925120
Biological Process	GO:0050771	negative regulation of axonogenesis	Tsc2	IMP		Rat	PMID:18794346\|RGD:11568688
Biological Process	GO:0030889	negative regulation of B cell proliferation	Tsc2	IGI	MGI:MGI:109583	Mouse	PMID:16027169
Biological Process	GO:0008285	negative regulation of cell population proliferation	Tsc2	IMP	MGI:MGI:1926345	Mouse	PMID:10096549
Biological Process	GO:0008285	negative regulation of cell population proliferation	Tsc2	IMP	MGI:MGI:1857938	Mouse	PMID:10491404
Biological Process	GO:0008285	negative regulation of cell population proliferation	Tsc2	IGI	MGI:MGI:109583	Mouse	PMID:16027168
Biological Process	GO:0008285	negative regulation of cell population proliferation	Tsc2	IMP		Mouse	PMID:10827137
Biological Process	GO:0008285	negative regulation of cell population proliferation	Tsc2	IMP		Rat	PMID:17376623\|RGD:11568689
Biological Process	GO:0045792	negative regulation of cell size	Tsc2	IMP		Rat	PMID:16286931\|RGD:8554187
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Tsc2	IDA		Rat	PMID:14612383\|RGD:1580517
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	Tsc2	IMP		Rat	PMID:20813961\|RGD:11568680
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Tsc2	IDA		Rat	PMID:18056446\|RGD:11568676
Biological Process	GO:0016242	negative regulation of macroautophagy	Tsc2	IMP		Rat	PMID:24599401\|RGD:11568679
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Tsc2	IMP		Rat	PMID:14612383\|RGD:1580517
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	Tsc2	IMP	MGI:MGI:1857938	Mouse	PMID:16027169
Biological Process	GO:0048550	negative regulation of pinocytosis	Tsc2	IMP		Rat	PMID:9045618\|RGD:11568652
Biological Process	GO:0006469	negative regulation of protein kinase activity	Tsc2	IMP		Mouse	PMID:15249583
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Tsc2	IGI	MGI:MGI:109583	Mouse	PMID:16027169
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Tsc2	IMP	MGI:MGI:1857938	Mouse	PMID:16027169
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Tsc2	IMP		Rat	PMID:18056446\|RGD:11568676
Biological Process	GO:0042130	negative regulation of T cell proliferation	Tsc2	IGI	MGI:MGI:109583	Mouse	PMID:16027169
Biological Process	GO:0032007	negative regulation of TOR signaling	TSC2	IDA		Human	PMID:22795129
Biological Process	GO:0032007	negative regulation of TOR signaling	TSC2	IGI	UniProtKB:Q61037	Human	PMID:23778976
Biological Process	GO:0032007	negative regulation of TOR signaling	Tsc2	IGI	UniProtKB:P49815	Mouse	MGI:MGI:5819337\|PMID:23778976
Biological Process	GO:0032007	negative regulation of TOR signaling	Tsc2	IMP		Mouse	PMID:18198340
Biological Process	GO:0032007	negative regulation of TOR signaling	Tsc2	IDA		Rat	PMID:12869586\|RGD:1580520
Biological Process	GO:0032007	negative regulation of TOR signaling	tsc2	IMP	ZFIN:ZDB-GENO-110414-1	Zfish	PMID:20959633
Biological Process	GO:1904262	negative regulation of TORC1 signaling	Tsc2	IMP		Mouse	MGI:MGI:5509101\|PMID:23878245
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	Tsc2	IMP		Rat	PMID:11553313\|RGD:11568654
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Tsc2	IDA		Rat	PMID:12511557\|RGD:1304267
Biological Process	GO:0001843	neural tube closure	Tsc2	IMP	MGI:MGI:1926345	Mouse	PMID:10096549
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Tsc2	IMP	MGI:MGI:1857938	Mouse	PMID:16027169
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Tsc2	IMP		Mouse	PMID:15249583
Biological Process	GO:0050918	positive chemotaxis	Tsc2	IMP		Mouse	PMID:15249583
Biological Process	GO:0010508	positive regulation of autophagy	Tsc2	IMP		Mouse	MGI:MGI:5509101\|PMID:23878245
Biological Process	GO:0045785	positive regulation of cell adhesion	Tsc2	IMP		Rat	PMID:20813961\|RGD:11568680
Biological Process	GO:0060999	positive regulation of dendritic spine development	Tsc2	IMP		Rat	PMID:16595860\|RGD:11568665
Biological Process	GO:0010763	positive regulation of fibroblast migration	Tsc2	IMP		Rat	PMID:20530489\|RGD:11568685
Biological Process	GO:0016239	positive regulation of macroautophagy	TSC2	IGI	UniProtKB:Q61037	Human	PMID:23778976
Biological Process	GO:0016239	positive regulation of macroautophagy	Tsc2	IMP		Mouse	MGI:MGI:5819337\|PMID:23778976
Biological Process	GO:0016239	positive regulation of macroautophagy	Tsc2	IMP		Mouse	PMID:20453062
Biological Process	GO:0010976	positive regulation of neuron projection development	Tsc2	IMP		Rat	PMID:17376623\|RGD:11568689
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Tsc2	IMP		Mouse	PMID:23858058
Biological Process	GO:0006606	protein import into nucleus	Tsc2	IMP		Mouse	PMID:10827137
Biological Process	GO:0043491	protein kinase B signaling	Tsc2	IMP	MGI:MGI:1857938	Mouse	PMID:16027169
Biological Process	GO:0043491	protein kinase B signaling	Tsc2	IGI	MGI:MGI:1270849	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Tsc2	IGI	MGI:MGI:99454	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Tsc2	IGI	MGI:MGI:1928394	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Tsc2	IGI	MGI:MGI:1927343	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Tsc2	IMP		Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Tsc2	IGI	MGI:MGI:87986	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Tsc2	IGI	MGI:MGI:109583	Mouse	PMID:16027169
Biological Process	GO:0008104	protein localization	Tsc2	IDA		Mouse	PMID:11741832
Biological Process	GO:0034394	protein localization to cell surface	Tsc2	IMP		Rat	PMID:20813961\|RGD:11568680
Biological Process	GO:0044861	protein transport into plasma membrane raft	Tsc2	IMP		Mouse	PMID:18511518
Biological Process	GO:0099608	regulation of action potential firing pattern	tsc2	IMP	ZFIN:ZDB-GENO-130916-1	Zfish	PMID:28888969
Biological Process	GO:0030100	regulation of endocytosis	Tsc2	IMP		Mouse	PMID:10827137
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	Tsc2	IMP	MGI:MGI:1857938	Mouse	PMID:12403809
Biological Process	GO:0099175	regulation of postsynapse organization	Tsc2	IDA		Rat	PMID:24889507\|RGD:13702223
Biological Process	GO:0099175	regulation of postsynapse organization	Tsc2	IMP		Rat	PMID:24889507\|RGD:13702223
Biological Process	GO:0001666	response to hypoxia	Tsc2	IMP		Mouse	PMID:18198340
Biological Process	GO:0007165	signal transduction	Tsc2	IDA		Rat	PMID:12045200\|RGD:625501
Biological Process	GO:0035176	social behavior	Tsc2	IMP		Rat	PMID:20927644\|RGD:11568683
Biological Process	GO:0042098	T cell proliferation	Tsc2	IGI	MGI:MGI:109583	Mouse	PMID:16027169
Biological Process	GO:0006366	transcription by RNA polymerase II	Tsc2	IMP		Mouse	PMID:23858058

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.