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Gene Ontology Browser
Term Detail
GO term:lysosome
GO id:GO:0005764
Definition:A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
Number of paths to term: 14

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasm
                                                        part-ofcytoplasmic part
                                                                is-avacuole
                                                                        is-alytic vacuole
                                                                                is-afungal-type vacuole +
                                                                                is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                                        is-acytolytic granule
                                                                                        is-aendolysosome +
                                                                                        part-oflysosomal glycocalyx
                                                                                        part-oflysosomal lumen +
                                                                                        part-oflysosomal membrane +
                                                                                        part-oflysosomal multienzyme complex
                                                                                        is-amast cell granule
                                                                                        is-amegasome
                                                                                        is-aprimary lysosome +
                                                                                        is-asecondary lysosome +
                                                                                        part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                                is-alytic vacuole within protein storage vacuole
                                                                                is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-acytoplasmic part
                                                        is-avacuole
                                                                is-alytic vacuole
                                                                        is-afungal-type vacuole +
                                                                        is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                                is-acytolytic granule
                                                                                is-aendolysosome +
                                                                                part-oflysosomal glycocalyx
                                                                                part-oflysosomal lumen +
                                                                                part-oflysosomal membrane +
                                                                                part-oflysosomal multienzyme complex
                                                                                is-amast cell granule
                                                                                is-amegasome
                                                                                is-aprimary lysosome +
                                                                                is-asecondary lysosome +
                                                                                part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                        is-alytic vacuole within protein storage vacuole
                                                                        is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-aintracellular organelle
                                                        is-aintracellular membrane-bounded organelle
                                                                is-avacuole
                                                                        is-alytic vacuole
                                                                                is-afungal-type vacuole +
                                                                                is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                                        is-acytolytic granule
                                                                                        is-aendolysosome +
                                                                                        part-oflysosomal glycocalyx
                                                                                        part-oflysosomal lumen +
                                                                                        part-oflysosomal membrane +
                                                                                        part-oflysosomal multienzyme complex
                                                                                        is-amast cell granule
                                                                                        is-amegasome
                                                                                        is-aprimary lysosome +
                                                                                        is-asecondary lysosome +
                                                                                        part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                                is-alytic vacuole within protein storage vacuole
                                                                                is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-avacuole
                                                                is-alytic vacuole
                                                                        is-afungal-type vacuole +
                                                                        is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                                is-acytolytic granule
                                                                                is-aendolysosome +
                                                                                part-oflysosomal glycocalyx
                                                                                part-oflysosomal lumen +
                                                                                part-oflysosomal membrane +
                                                                                part-oflysosomal multienzyme complex
                                                                                is-amast cell granule
                                                                                is-amegasome
                                                                                is-aprimary lysosome +
                                                                                is-asecondary lysosome +
                                                                                part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                        is-alytic vacuole within protein storage vacuole
                                                                        is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-acytoplasmic part
                                                is-avacuole
                                                        is-alytic vacuole
                                                                is-afungal-type vacuole +
                                                                is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                        is-acytolytic granule
                                                                        is-aendolysosome +
                                                                        part-oflysosomal glycocalyx
                                                                        part-oflysosomal lumen +
                                                                        part-oflysosomal membrane +
                                                                        part-oflysosomal multienzyme complex
                                                                        is-amast cell granule
                                                                        is-amegasome
                                                                        is-aprimary lysosome +
                                                                        is-asecondary lysosome +
                                                                        part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                is-alytic vacuole within protein storage vacuole
                                                                is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular membrane-bounded organelle
                                                        is-avacuole
                                                                is-alytic vacuole
                                                                        is-afungal-type vacuole +
                                                                        is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                                is-acytolytic granule
                                                                                is-aendolysosome +
                                                                                part-oflysosomal glycocalyx
                                                                                part-oflysosomal lumen +
                                                                                part-oflysosomal membrane +
                                                                                part-oflysosomal multienzyme complex
                                                                                is-amast cell granule
                                                                                is-amegasome
                                                                                is-aprimary lysosome +
                                                                                is-asecondary lysosome +
                                                                                part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                        is-alytic vacuole within protein storage vacuole
                                                                        is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasm
                                                part-ofcytoplasmic part
                                                        is-avacuole
                                                                is-alytic vacuole
                                                                        is-afungal-type vacuole +
                                                                        is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                                is-acytolytic granule
                                                                                is-aendolysosome +
                                                                                part-oflysosomal glycocalyx
                                                                                part-oflysosomal lumen +
                                                                                part-oflysosomal membrane +
                                                                                part-oflysosomal multienzyme complex
                                                                                is-amast cell granule
                                                                                is-amegasome
                                                                                is-aprimary lysosome +
                                                                                is-asecondary lysosome +
                                                                                part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                        is-alytic vacuole within protein storage vacuole
                                                                        is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-acytoplasmic part
                                                is-avacuole
                                                        is-alytic vacuole
                                                                is-afungal-type vacuole +
                                                                is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                        is-acytolytic granule
                                                                        is-aendolysosome +
                                                                        part-oflysosomal glycocalyx
                                                                        part-oflysosomal lumen +
                                                                        part-oflysosomal membrane +
                                                                        part-oflysosomal multienzyme complex
                                                                        is-amast cell granule
                                                                        is-amegasome
                                                                        is-aprimary lysosome +
                                                                        is-asecondary lysosome +
                                                                        part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                is-alytic vacuole within protein storage vacuole
                                                                is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular membrane-bounded organelle
                                                        is-avacuole
                                                                is-alytic vacuole
                                                                        is-afungal-type vacuole +
                                                                        is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                                is-acytolytic granule
                                                                                is-aendolysosome +
                                                                                part-oflysosomal glycocalyx
                                                                                part-oflysosomal lumen +
                                                                                part-oflysosomal membrane +
                                                                                part-oflysosomal multienzyme complex
                                                                                is-amast cell granule
                                                                                is-amegasome
                                                                                is-aprimary lysosome +
                                                                                is-asecondary lysosome +
                                                                                part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                        is-alytic vacuole within protein storage vacuole
                                                                        is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasm
                                        part-ofcytoplasmic part
                                                is-avacuole
                                                        is-alytic vacuole
                                                                is-afungal-type vacuole +
                                                                is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                        is-acytolytic granule
                                                                        is-aendolysosome +
                                                                        part-oflysosomal glycocalyx
                                                                        part-oflysosomal lumen +
                                                                        part-oflysosomal membrane +
                                                                        part-oflysosomal multienzyme complex
                                                                        is-amast cell granule
                                                                        is-amegasome
                                                                        is-aprimary lysosome +
                                                                        is-asecondary lysosome +
                                                                        part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                is-alytic vacuole within protein storage vacuole
                                                                is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-acytoplasmic part
                                        is-avacuole
                                                is-alytic vacuole
                                                        is-afungal-type vacuole +
                                                        is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                is-acytolytic granule
                                                                is-aendolysosome +
                                                                part-oflysosomal glycocalyx
                                                                part-oflysosomal lumen +
                                                                part-oflysosomal membrane +
                                                                part-oflysosomal multienzyme complex
                                                                is-amast cell granule
                                                                is-amegasome
                                                                is-aprimary lysosome +
                                                                is-asecondary lysosome +
                                                                part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                        is-alytic vacuole within protein storage vacuole
                                                        is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-aintracellular organelle
                                        is-aintracellular membrane-bounded organelle
                                                is-avacuole
                                                        is-alytic vacuole
                                                                is-afungal-type vacuole +
                                                                is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                        is-acytolytic granule
                                                                        is-aendolysosome +
                                                                        part-oflysosomal glycocalyx
                                                                        part-oflysosomal lumen +
                                                                        part-oflysosomal membrane +
                                                                        part-oflysosomal multienzyme complex
                                                                        is-amast cell granule
                                                                        is-amegasome
                                                                        is-aprimary lysosome +
                                                                        is-asecondary lysosome +
                                                                        part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                                is-alytic vacuole within protein storage vacuole
                                                                is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-aintracellular organelle
                                is-aintracellular membrane-bounded organelle
                                        is-avacuole
                                                is-alytic vacuole
                                                        is-afungal-type vacuole +
                                                        is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                is-acytolytic granule
                                                                is-aendolysosome +
                                                                part-oflysosomal glycocalyx
                                                                part-oflysosomal lumen +
                                                                part-oflysosomal membrane +
                                                                part-oflysosomal multienzyme complex
                                                                is-amast cell granule
                                                                is-amegasome
                                                                is-aprimary lysosome +
                                                                is-asecondary lysosome +
                                                                part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                        is-alytic vacuole within protein storage vacuole
                                                        is-asenescence-associated vacuole


Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-amembrane-bounded organelle
                                is-aintracellular membrane-bounded organelle
                                        is-avacuole
                                                is-alytic vacuole
                                                        is-afungal-type vacuole +
                                                        is-alysosome [GO:0005764] (398 genes, 520 annotations)
                                                                is-acytolytic granule
                                                                is-aendolysosome +
                                                                part-oflysosomal glycocalyx
                                                                part-oflysosomal lumen +
                                                                part-oflysosomal membrane +
                                                                part-oflysosomal multienzyme complex
                                                                is-amast cell granule
                                                                is-amegasome
                                                                is-aprimary lysosome +
                                                                is-asecondary lysosome +
                                                                part-ofUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
                                                        is-alytic vacuole within protein storage vacuole
                                                        is-asenescence-associated vacuole


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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory