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Gene Ontology Browser
Term Detail
GO term:postsynaptic density
Synonym: neuronal postsynaptic density
Synonym: post synaptic density
Synonym: post-synaptic density
GO id:GO:0014069
Alternate id: GO:0097483, GO:0097481
Definition:The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms an electron-dense disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases.
Number of paths to term: 20

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-acell projection
                                        part-ofcell projection part
                                                is-aactin filament bundle of actin-based cell projection +
                                                is-aactin fusion focus
                                                is-aaxon part +
                                                is-abacterial-type flagellum part +
                                                is-acell projection cytoplasm +
                                                is-acell projection membrane +
                                                is-aciliary part +
                                                is-acytoplasmic side of dendritic spine plasma membrane
                                                is-acytoskeleton of dendritic spine +
                                                is-adeep fiber
                                                is-adendrite terminus +
                                                is-adendritic branch
                                                is-adendritic branch point
                                                is-adendritic filopodium
                                                is-adendritic lamellar body
                                                is-adendritic microtubule
                                                is-adendritic shaft
                                                is-adendritic spine +
                                                is-adendritic spine head
                                                is-adendritic spine neck
                                                is-aextrinsic component of spine apparatus membrane
                                                is-afilopodium tip
                                                is-agrowth cone +
                                                is-agrowth cone filopodium
                                                is-agrowth cone lamellipodium
                                                is-agrowth cone membrane
                                                is-ainaD signaling complex
                                                is-aintegral component of muscle cell projection membrane
                                                is-aintrinsic component of spine apparatus membrane
                                                is-aleft lateral basal body pair
                                                is-aleft middle basal body pair
                                                is-aleft tetrad
                                                is-amacropinocytic cup cytoskeleton
                                                is-amating projection base
                                                is-amating projection septin band
                                                is-amating projection septin ring
                                                is-amating projection tip +
                                                is-amating projection tip membrane
                                                is-amating projection tip polarisome
                                                is-aneuron projection terminus +
                                                is-aneuronal ribonucleoprotein granule
                                                is-apilus part +
                                                is-apollen tube tip
                                                is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                        is-aglutamatergic postsynaptic density
                                                is-aproximal dendrite
                                                is-arhabdomere microvillus +
                                                is-aright lateral basal body pair
                                                is-aright middle basal body pair
                                                is-aright tetrad
                                                is-aroot hair tip
                                                is-aspine apparatus +
                                                is-aspine apparatus lumen
                                                is-aspine apparatus membrane +
                                                is-astereocilia tip-link density +
                                                is-astereocilium tip
                                                is-asubrhabdomeral cisterna
                                                is-aunicellular trichome apex +
                                                is-aunicellular trichome branch
                                                is-aunicellular trichome tip


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-acell projection part
                                        is-aactin filament bundle of actin-based cell projection +
                                        is-aactin fusion focus
                                        is-aaxon part +
                                        is-abacterial-type flagellum part +
                                        is-acell projection cytoplasm +
                                        is-acell projection membrane +
                                        is-aciliary part +
                                        is-acytoplasmic side of dendritic spine plasma membrane
                                        is-acytoskeleton of dendritic spine +
                                        is-adeep fiber
                                        is-adendrite terminus +
                                        is-adendritic branch
                                        is-adendritic branch point
                                        is-adendritic filopodium
                                        is-adendritic lamellar body
                                        is-adendritic microtubule
                                        is-adendritic shaft
                                        is-adendritic spine +
                                        is-adendritic spine head
                                        is-adendritic spine neck
                                        is-aextrinsic component of spine apparatus membrane
                                        is-afilopodium tip
                                        is-agrowth cone +
                                        is-agrowth cone filopodium
                                        is-agrowth cone lamellipodium
                                        is-agrowth cone membrane
                                        is-ainaD signaling complex
                                        is-aintegral component of muscle cell projection membrane
                                        is-aintrinsic component of spine apparatus membrane
                                        is-aleft lateral basal body pair
                                        is-aleft middle basal body pair
                                        is-aleft tetrad
                                        is-amacropinocytic cup cytoskeleton
                                        is-amating projection base
                                        is-amating projection septin band
                                        is-amating projection septin ring
                                        is-amating projection tip +
                                        is-amating projection tip membrane
                                        is-amating projection tip polarisome
                                        is-aneuron projection terminus +
                                        is-aneuronal ribonucleoprotein granule
                                        is-apilus part +
                                        is-apollen tube tip
                                        is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                is-aglutamatergic postsynaptic density
                                        is-aproximal dendrite
                                        is-arhabdomere microvillus +
                                        is-aright lateral basal body pair
                                        is-aright middle basal body pair
                                        is-aright tetrad
                                        is-aroot hair tip
                                        is-aspine apparatus +
                                        is-aspine apparatus lumen
                                        is-aspine apparatus membrane +
                                        is-astereocilia tip-link density +
                                        is-astereocilium tip
                                        is-asubrhabdomeral cisterna
                                        is-aunicellular trichome apex +
                                        is-aunicellular trichome branch
                                        is-aunicellular trichome tip


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular
                                        part-ofintracellular part
                                                is-aintracellular organelle
                                                        is-aintracellular non-membrane-bounded organelle
                                                                is-apostsynaptic specialization
                                                                        is-amuscle cell postsynaptic density
                                                                        is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                                                is-aglutamatergic postsynaptic density
                                                                        is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular non-membrane-bounded organelle
                                                        is-apostsynaptic specialization
                                                                is-amuscle cell postsynaptic density
                                                                is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                                        is-aglutamatergic postsynaptic density
                                                                is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aneuron part
                                        is-aaccessory outer segment
                                        is-aactin filament bundle of stereocilium
                                        is-aapical pole of neuron
                                        is-aaxon part +
                                        is-abasal pole of neuron
                                        is-aclathrin coat of synaptic vesicle
                                        is-acuticular plate
                                        is-acytoplasmic side of dendritic spine plasma membrane
                                        is-acytoskeleton of dendritic spine +
                                        is-adendrite cytoplasm
                                        is-adendrite terminus +
                                        is-adendritic branch
                                        is-adendritic branch point
                                        is-adendritic filopodium
                                        is-adendritic lamellar body
                                        is-adendritic microtubule
                                        is-adendritic shaft
                                        is-adendritic spine head
                                        is-adendritic spine neck
                                        is-adendritic tree
                                        is-aextrinsic component of presynaptic membrane +
                                        is-aextrinsic component of spine apparatus membrane
                                        is-aextrinsic component of synaptic vesicle membrane
                                        is-agrowth cone +
                                        is-agrowth cone filopodium
                                        is-agrowth cone lamellipodium
                                        is-agrowth cone membrane
                                        is-aintrinsic component of presynaptic endosome membrane
                                        is-aintrinsic component of presynaptic membrane +
                                        is-aintrinsic component of spine apparatus membrane
                                        is-aintrinsic component of synaptic vesicle membrane +
                                        is-akinociliary basal body
                                        is-akinocilium +
                                        is-aLewy body +
                                        is-aLewy body core
                                        is-aLewy body corona
                                        is-aLewy body-like hyaline inclusion
                                        is-anBAF complex
                                        is-aneurofibrillary tangle
                                        is-aneurofilament cytoskeleton
                                        is-aneuron projection +
                                        is-aneuron projection membrane +
                                        is-aneuron projection terminus +
                                        is-aneuronal cell body +
                                        is-aneuronal cell body membrane
                                        is-aneuronal dense core vesicle
                                        is-aneuronal ribonucleoprotein granule
                                        is-aperikaryon
                                        is-aphotoreceptor disc membrane
                                        is-aphotoreceptor inner segment +
                                        is-aphotoreceptor inner segment membrane
                                        is-aphotoreceptor outer segment +
                                        is-aphotoreceptor outer segment membrane
                                        is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                is-aglutamatergic postsynaptic density
                                        is-apresynapse +
                                        is-apresynaptic active zone +
                                        is-apresynaptic active zone cytoplasmic component +
                                        is-apresynaptic active zone dense projection
                                        is-apresynaptic active zone membrane +
                                        is-apresynaptic cytoskeleton +
                                        is-apresynaptic cytosol
                                        is-apresynaptic endocytic zone +
                                        is-apresynaptic endocytic zone cytoplasmic component
                                        is-apresynaptic endocytic zone membrane +
                                        is-apresynaptic endosome +
                                        is-apresynaptic endosome membrane +
                                        is-apresynaptic grid
                                        is-apresynaptic membrane +
                                        is-apresynaptic periactive zone
                                        is-aproximal dendrite
                                        is-asomatodendritic compartment +
                                        is-aspine apparatus +
                                        is-aspine apparatus membrane +
                                        is-aspine mat
                                        is-astereocilia ankle link complex
                                        is-astereocilia coupling link +
                                        is-astereocilia tip-link density +
                                        is-astereocilium +
                                        is-astereocilium bundle +
                                        is-astereocilium membrane
                                        is-astereocilium tip
                                        is-asubplasmalemmal coating
                                        is-asynaptic vesicle +
                                        is-asynaptic vesicle lumen +
                                        is-asynaptic vesicle membrane +


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-apostsynapse
                                        part-ofpostsynaptic specialization
                                                is-amuscle cell postsynaptic density
                                                is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                        is-aglutamatergic postsynaptic density
                                                is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-acell projection
                                part-ofcell projection part
                                        is-aactin filament bundle of actin-based cell projection +
                                        is-aactin fusion focus
                                        is-aaxon part +
                                        is-abacterial-type flagellum part +
                                        is-acell projection cytoplasm +
                                        is-acell projection membrane +
                                        is-aciliary part +
                                        is-acytoplasmic side of dendritic spine plasma membrane
                                        is-acytoskeleton of dendritic spine +
                                        is-adeep fiber
                                        is-adendrite terminus +
                                        is-adendritic branch
                                        is-adendritic branch point
                                        is-adendritic filopodium
                                        is-adendritic lamellar body
                                        is-adendritic microtubule
                                        is-adendritic shaft
                                        is-adendritic spine +
                                        is-adendritic spine head
                                        is-adendritic spine neck
                                        is-aextrinsic component of spine apparatus membrane
                                        is-afilopodium tip
                                        is-agrowth cone +
                                        is-agrowth cone filopodium
                                        is-agrowth cone lamellipodium
                                        is-agrowth cone membrane
                                        is-ainaD signaling complex
                                        is-aintegral component of muscle cell projection membrane
                                        is-aintrinsic component of spine apparatus membrane
                                        is-aleft lateral basal body pair
                                        is-aleft middle basal body pair
                                        is-aleft tetrad
                                        is-amacropinocytic cup cytoskeleton
                                        is-amating projection base
                                        is-amating projection septin band
                                        is-amating projection septin ring
                                        is-amating projection tip +
                                        is-amating projection tip membrane
                                        is-amating projection tip polarisome
                                        is-aneuron projection terminus +
                                        is-aneuronal ribonucleoprotein granule
                                        is-apilus part +
                                        is-apollen tube tip
                                        is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                is-aglutamatergic postsynaptic density
                                        is-aproximal dendrite
                                        is-arhabdomere microvillus +
                                        is-aright lateral basal body pair
                                        is-aright middle basal body pair
                                        is-aright tetrad
                                        is-aroot hair tip
                                        is-aspine apparatus +
                                        is-aspine apparatus lumen
                                        is-aspine apparatus membrane +
                                        is-astereocilia tip-link density +
                                        is-astereocilium tip
                                        is-asubrhabdomeral cisterna
                                        is-aunicellular trichome apex +
                                        is-aunicellular trichome branch
                                        is-aunicellular trichome tip


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-acell projection part
                                is-aactin filament bundle of actin-based cell projection +
                                is-aactin fusion focus
                                is-aaxon part +
                                is-abacterial-type flagellum part +
                                is-acell projection cytoplasm +
                                is-acell projection membrane +
                                is-aciliary part +
                                is-acytoplasmic side of dendritic spine plasma membrane
                                is-acytoskeleton of dendritic spine +
                                is-adeep fiber
                                is-adendrite terminus +
                                is-adendritic branch
                                is-adendritic branch point
                                is-adendritic filopodium
                                is-adendritic lamellar body
                                is-adendritic microtubule
                                is-adendritic shaft
                                is-adendritic spine +
                                is-adendritic spine head
                                is-adendritic spine neck
                                is-aextrinsic component of spine apparatus membrane
                                is-afilopodium tip
                                is-agrowth cone +
                                is-agrowth cone filopodium
                                is-agrowth cone lamellipodium
                                is-agrowth cone membrane
                                is-ainaD signaling complex
                                is-aintegral component of muscle cell projection membrane
                                is-aintrinsic component of spine apparatus membrane
                                is-aleft lateral basal body pair
                                is-aleft middle basal body pair
                                is-aleft tetrad
                                is-amacropinocytic cup cytoskeleton
                                is-amating projection base
                                is-amating projection septin band
                                is-amating projection septin ring
                                is-amating projection tip +
                                is-amating projection tip membrane
                                is-amating projection tip polarisome
                                is-aneuron projection terminus +
                                is-aneuronal ribonucleoprotein granule
                                is-apilus part +
                                is-apollen tube tip
                                is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                        is-aglutamatergic postsynaptic density
                                is-aproximal dendrite
                                is-arhabdomere microvillus +
                                is-aright lateral basal body pair
                                is-aright middle basal body pair
                                is-aright tetrad
                                is-aroot hair tip
                                is-aspine apparatus +
                                is-aspine apparatus lumen
                                is-aspine apparatus membrane +
                                is-astereocilia tip-link density +
                                is-astereocilium tip
                                is-asubrhabdomeral cisterna
                                is-aunicellular trichome apex +
                                is-aunicellular trichome branch
                                is-aunicellular trichome tip


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular
                                part-ofintracellular part
                                        is-aintracellular organelle
                                                is-aintracellular non-membrane-bounded organelle
                                                        is-apostsynaptic specialization
                                                                is-amuscle cell postsynaptic density
                                                                is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                                        is-aglutamatergic postsynaptic density
                                                                is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aintracellular part
                                is-aintracellular organelle
                                        is-aintracellular non-membrane-bounded organelle
                                                is-apostsynaptic specialization
                                                        is-amuscle cell postsynaptic density
                                                        is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                                is-aglutamatergic postsynaptic density
                                                        is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aneuron part
                                is-aaccessory outer segment
                                is-aactin filament bundle of stereocilium
                                is-aapical pole of neuron
                                is-aaxon part +
                                is-abasal pole of neuron
                                is-aclathrin coat of synaptic vesicle
                                is-acuticular plate
                                is-acytoplasmic side of dendritic spine plasma membrane
                                is-acytoskeleton of dendritic spine +
                                is-adendrite cytoplasm
                                is-adendrite terminus +
                                is-adendritic branch
                                is-adendritic branch point
                                is-adendritic filopodium
                                is-adendritic lamellar body
                                is-adendritic microtubule
                                is-adendritic shaft
                                is-adendritic spine head
                                is-adendritic spine neck
                                is-adendritic tree
                                is-aextrinsic component of presynaptic membrane +
                                is-aextrinsic component of spine apparatus membrane
                                is-aextrinsic component of synaptic vesicle membrane
                                is-agrowth cone +
                                is-agrowth cone filopodium
                                is-agrowth cone lamellipodium
                                is-agrowth cone membrane
                                is-aintrinsic component of presynaptic endosome membrane
                                is-aintrinsic component of presynaptic membrane +
                                is-aintrinsic component of spine apparatus membrane
                                is-aintrinsic component of synaptic vesicle membrane +
                                is-akinociliary basal body
                                is-akinocilium +
                                is-aLewy body +
                                is-aLewy body core
                                is-aLewy body corona
                                is-aLewy body-like hyaline inclusion
                                is-anBAF complex
                                is-aneurofibrillary tangle
                                is-aneurofilament cytoskeleton
                                is-aneuron projection +
                                is-aneuron projection membrane +
                                is-aneuron projection terminus +
                                is-aneuronal cell body +
                                is-aneuronal cell body membrane
                                is-aneuronal dense core vesicle
                                is-aneuronal ribonucleoprotein granule
                                is-aperikaryon
                                is-aphotoreceptor disc membrane
                                is-aphotoreceptor inner segment +
                                is-aphotoreceptor inner segment membrane
                                is-aphotoreceptor outer segment +
                                is-aphotoreceptor outer segment membrane
                                is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                        is-aglutamatergic postsynaptic density
                                is-apresynapse +
                                is-apresynaptic active zone +
                                is-apresynaptic active zone cytoplasmic component +
                                is-apresynaptic active zone dense projection
                                is-apresynaptic active zone membrane +
                                is-apresynaptic cytoskeleton +
                                is-apresynaptic cytosol
                                is-apresynaptic endocytic zone +
                                is-apresynaptic endocytic zone cytoplasmic component
                                is-apresynaptic endocytic zone membrane +
                                is-apresynaptic endosome +
                                is-apresynaptic endosome membrane +
                                is-apresynaptic grid
                                is-apresynaptic membrane +
                                is-apresynaptic periactive zone
                                is-aproximal dendrite
                                is-asomatodendritic compartment +
                                is-aspine apparatus +
                                is-aspine apparatus membrane +
                                is-aspine mat
                                is-astereocilia ankle link complex
                                is-astereocilia coupling link +
                                is-astereocilia tip-link density +
                                is-astereocilium +
                                is-astereocilium bundle +
                                is-astereocilium membrane
                                is-astereocilium tip
                                is-asubplasmalemmal coating
                                is-asynaptic vesicle +
                                is-asynaptic vesicle lumen +
                                is-asynaptic vesicle membrane +


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-apostsynapse
                                part-ofpostsynaptic specialization
                                        is-amuscle cell postsynaptic density
                                        is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                is-aglutamatergic postsynaptic density
                                        is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-aintracellular organelle
                                is-aintracellular non-membrane-bounded organelle
                                        is-apostsynaptic specialization
                                                is-amuscle cell postsynaptic density
                                                is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                        is-aglutamatergic postsynaptic density
                                                is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-aorganelle
                        is-anon-membrane-bounded organelle
                                is-aintracellular non-membrane-bounded organelle
                                        is-apostsynaptic specialization
                                                is-amuscle cell postsynaptic density
                                                is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                        is-aglutamatergic postsynaptic density
                                                is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse
                        is-aexcitatory synapse
                                is-aasymmetric, glutamateric, excitatory synapse
                                is-aexcitatory neuromuscular junction +
                                part-ofpostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                        is-aglutamatergic postsynaptic density


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse
                        part-ofpostsynapse
                                part-ofpostsynaptic specialization
                                        is-amuscle cell postsynaptic density
                                        is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                is-aglutamatergic postsynaptic density
                                        is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse
                        part-ofsynapse part
                                is-apostsynapse
                                        part-ofpostsynaptic specialization
                                                is-amuscle cell postsynaptic density
                                                is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                        is-aglutamatergic postsynaptic density
                                                is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse
                        part-ofsynapse part
                                is-apostsynaptic specialization
                                        is-amuscle cell postsynaptic density
                                        is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                is-aglutamatergic postsynaptic density
                                        is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse part
                        is-apostsynapse
                                part-ofpostsynaptic specialization
                                        is-amuscle cell postsynaptic density
                                        is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                                is-aglutamatergic postsynaptic density
                                        is-apostsynaptic specialization of symmetric synapse


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse part
                        is-apostsynaptic specialization
                                is-amuscle cell postsynaptic density
                                is-apostsynaptic density [GO:0014069] (208 genes, 235 annotations)
                                        is-aglutamatergic postsynaptic density
                                is-apostsynaptic specialization of symmetric synapse


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory