| GO term: | negative regulation of MAP kinase activity |
| Synonym: | down regulation of MAPK activity |
| Synonym: | down-regulation of MAPK activity |
| Synonym: | downregulation of MAPK activity |
| Synonym: | inhibition of MAPK activity |
| Synonym: | negative regulation of mitogen activated protein kinase activity |
| Synonym: | negative regulation of mitogen-activated protein kinase activity |
| GO id: | GO:0043407 |
| Definition: | Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. |
| Number of paths to term: | 690 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of cellular processnegative regulation of cell communicationnegative regulation of signal transductionnegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of cellular processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of cellular processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of metabolic processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of metabolic processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of metabolic processnegative regulation of macromolecule metabolic processnegative regulation of protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of response to stimulusnegative regulation of signal transductionnegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of signalingnegative regulation of signal transductionnegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processnegative regulation of cellular processnegative regulation of cell communicationnegative regulation of signal transductionnegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processnegative regulation of cellular processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processnegative regulation of cellular processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationnegative regulation of cell communicationnegative regulation of signal transductionnegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationregulation of signal transductionnegative regulation of signal transductionnegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationregulation of signal transductionregulation of intracellular protein kinase cascadenegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationregulation of signal transductionregulation of intracellular protein kinase cascaderegulation of MAPK cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationregulation of signal transductionregulation of intracellular protein kinase cascaderegulation of MAPK cascaderegulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of cellular protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activityregulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activitynegative regulation of kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activityregulation of protein kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activityregulation of protein kinase activityregulation of protein serine/threonine kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activityregulation of protein kinase activityregulation of protein serine/threonine kinase activityregulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activityregulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascaderegulation of MAPK cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascaderegulation of MAPK cascaderegulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadenegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascaderegulation of intracellular protein kinase cascadenegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascaderegulation of intracellular protein kinase cascaderegulation of MAPK cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascaderegulation of intracellular protein kinase cascaderegulation of MAPK cascaderegulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionnegative regulation of signal transductionnegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionregulation of signal transductionnegative regulation of signal transductionnegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionregulation of signal transductionregulation of intracellular protein kinase cascadenegative regulation of intracellular protein kinase cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionregulation of signal transductionregulation of intracellular protein kinase cascaderegulation of MAPK cascadenegative regulation of MAPK cascadeinactivation of MAPKK activityinactivation of MAPKKK activitynegative regulation of ERK1 and ERK2 cascadenegative regulation of ERK5 cascadenegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionregulation of signal transductionregulation of intracellular protein kinase cascaderegulation of MAPK cascaderegulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processnegative regulation of metabolic processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processnegative regulation of metabolic processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processnegative regulation of metabolic processnegative regulation of macromolecule metabolic processnegative regulation of protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activitynegative regulation of catalytic activitynegative regulation of transferase activitynegative regulation of kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of transferase activitynegative regulation of transferase activitynegative regulation of kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of transferase activityregulation of kinase activitynegative regulation of kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of transferase activityregulation of kinase activityregulation of protein kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of transferase activityregulation of kinase activityregulation of protein kinase activityregulation of protein serine/threonine kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of transferase activityregulation of kinase activityregulation of protein kinase activityregulation of protein serine/threonine kinase activityregulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processnegative regulation of cellular metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processnegative regulation of cellular metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of cellular protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activityregulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processnegative regulation of phosphorus metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processnegative regulation of phosphate metabolic processnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationnegative regulation of phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activitynegative regulation of kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activityregulation of protein kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activityregulation of protein kinase activityregulation of protein serine/threonine kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of kinase activityregulation of protein kinase activityregulation of protein serine/threonine kinase activityregulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of phosphorylationregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activityregulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processnegative regulation of macromolecule metabolic processnegative regulation of protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processnegative regulation of protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of macromolecule metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activityregulation of MAP kinase activitynegative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitypositive regulation of MAP kinase activity +regulation of JUN kinase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processnegative regulation of protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processnegative regulation of cellular protein metabolic processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processnegative regulation of protein modification processnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationnegative regulation of protein phosphorylationnegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activitynegative regulation of protein kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +negative regulation of MAP kinase activity [GO:0043407] (58 genes, 70 annotations)inactivation of MAPK activity +negative regulation of JUN kinase activitynegative regulation of myosin light chain kinase activitynegative regulation of Rho-dependent protein serine/threonine kinase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of primary metabolic processregulation of protein metabolic processregulation of cellular protein metabolic processregulation of protein modification processregulation of protein phosphorylationregulation of protein kinase activityregulation of protein serine/threonine kinase activitynegative regulation of protein serine/threonine kinase activityinactivation of MAPKKK activitynegative regulation of cAMP-dependent protein kinase activitynegative regulation of cyclin-dependent protein serine/threonine kinase activity +
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