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Gene Ontology Browser
Term Detail
GO term:signal transduction
Synonym: signaling cascade
Synonym: signaling pathway
Synonym: signalling cascade
Synonym: signalling pathway
GO id:GO:0007165
Definition:The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
CommentsNote that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-acell redox homeostasis
                                        is-amodulation by symbiont of host cellular process +
                                        is-amodulation of symbiont cell wall strengthening involved in entry into host +
                                        is-anegative regulation of cellular process +
                                        is-apositive regulation of cellular process +
                                        is-aregulation of actin filament-based process +
                                        is-aregulation of barbed-end actin filament capping +
                                        is-aregulation of binding of sperm to zona pellucida +
                                        is-aregulation of blood microparticle formation +
                                        is-aregulation of capsule organization +
                                        is-aregulation of cell activation +
                                        is-aregulation of cell adhesion +
                                        is-aregulation of cell adhesion molecule production +
                                        is-aregulation of cell aging +
                                        is-aregulation of cell communication +
                                        is-aregulation of cell cycle +
                                        is-aregulation of cell death +
                                        is-aregulation of cell differentiation +
                                        is-aregulation of cell division +
                                        is-aregulation of cell growth +
                                        is-aregulation of cell junction assembly +
                                        is-aregulation of cell morphogenesis +
                                        is-aregulation of cell projection organization +
                                        is-aregulation of cell proliferation +
                                        is-aregulation of cell wall pectin metabolic process
                                        is-aregulation of cellular component movement +
                                        is-aregulation of cellular localization +
                                        is-aregulation of cellular metabolic process +
                                        is-aregulation of cellular pH reduction +
                                        is-aregulation of cellular response to alkalinity +
                                        is-aregulation of cellular response to drug +
                                        is-aregulation of cellular response to growth factor stimulus +
                                        is-aregulation of cellular response to insulin stimulus +
                                        is-aregulation of cellular response to stress +
                                        is-aregulation of cellular response to testosterone stimulus +
                                        is-aregulation of cellular response to X-ray +
                                        is-aregulation of chromosome segregation +
                                        is-aregulation of conjugation +
                                        is-aregulation of dendritic spine maintenance +
                                        is-aregulation of dynamin polymerization involved in membrane fission
                                        is-aregulation of establishment or maintenance of cell polarity +
                                        is-aregulation of extracellular matrix organization +
                                        is-aregulation of fibril organization +
                                        is-aregulation of flocculation +
                                        is-aregulation of fungal-type cell wall biogenesis +
                                        is-aregulation of fungal-type cell wall organization +
                                        is-aregulation of fusion of sperm to egg plasma membrane +
                                        is-aregulation of gene silencing +
                                        is-aregulation of integrin biosynthetic process +
                                        is-aregulation of ligand-dependent nuclear receptor transcription coactivator activity +
                                        is-aregulation of membrane depolarization +
                                        is-aregulation of membrane disassembly +
                                        is-aregulation of microtubule-based process +
                                        is-aregulation of myelination +
                                        is-aregulation of organelle organization +
                                        is-aregulation of phenotypic switching +
                                        is-aregulation of phospholipid scramblase activity +
                                        is-aregulation of phospholipid translocation +
                                        is-aregulation of plant-type cell wall organization or biogenesis
                                        is-aregulation of postsynaptic membrane organization +
                                        is-aregulation of presynaptic membrane organization +
                                        is-aregulation of protein complex disassembly +
                                        is-aregulation of response to cell cycle checkpoint signaling +
                                        is-aregulation of secondary cell wall biogenesis +
                                        is-aregulation of sequestering of calcium ion +
                                        is-aregulation of sequestering of zinc ion +
                                        is-aregulation of single-species biofilm formation +
                                        is-aregulation of stomatal movement +
                                        is-aregulation of synapse organization +
                                        is-aregulation of synaptic vesicle membrane organization +
                                        is-aregulation of syncytium formation by plasma membrane fusion +
                                        is-aregulation of transmembrane transport +
                                        is-aregulation of transposition +
                                        is-aregulation of ubiquitin homeostasis +
                                        is-aregulation of vesicle-mediated transport +
                                        is-aregulation of viral process +
                                        is-asignal transduction [GO:0007165] (5409 genes, 13788 annotations)
                                                is-aapoptotic signaling pathway +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphosphorelay signal transduction system +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in regulation of gene expression
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular pigment accumulation +
                                is-acellular response to abiotic stimulus +
                                is-acellular response to biotic stimulus +
                                is-acellular response to cell wall damage
                                is-acellular response to chemical stimulus +
                                is-acellular response to extracellular stimulus +
                                is-acellular response to stress +
                                is-asignal transduction [GO:0007165] (5409 genes, 13788 annotations)
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +
                                is-askeletal muscle fiber adaptation


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-acell redox homeostasis
                                is-amodulation by symbiont of host cellular process +
                                is-amodulation of symbiont cell wall strengthening involved in entry into host +
                                is-anegative regulation of cellular process +
                                is-apositive regulation of cellular process +
                                is-aregulation of actin filament-based process +
                                is-aregulation of barbed-end actin filament capping +
                                is-aregulation of binding of sperm to zona pellucida +
                                is-aregulation of blood microparticle formation +
                                is-aregulation of capsule organization +
                                is-aregulation of cell activation +
                                is-aregulation of cell adhesion +
                                is-aregulation of cell adhesion molecule production +
                                is-aregulation of cell aging +
                                is-aregulation of cell communication +
                                is-aregulation of cell cycle +
                                is-aregulation of cell death +
                                is-aregulation of cell differentiation +
                                is-aregulation of cell division +
                                is-aregulation of cell growth +
                                is-aregulation of cell junction assembly +
                                is-aregulation of cell morphogenesis +
                                is-aregulation of cell projection organization +
                                is-aregulation of cell proliferation +
                                is-aregulation of cell wall pectin metabolic process
                                is-aregulation of cellular component movement +
                                is-aregulation of cellular localization +
                                is-aregulation of cellular metabolic process +
                                is-aregulation of cellular pH reduction +
                                is-aregulation of cellular response to alkalinity +
                                is-aregulation of cellular response to drug +
                                is-aregulation of cellular response to growth factor stimulus +
                                is-aregulation of cellular response to insulin stimulus +
                                is-aregulation of cellular response to stress +
                                is-aregulation of cellular response to testosterone stimulus +
                                is-aregulation of cellular response to X-ray +
                                is-aregulation of chromosome segregation +
                                is-aregulation of conjugation +
                                is-aregulation of dendritic spine maintenance +
                                is-aregulation of dynamin polymerization involved in membrane fission
                                is-aregulation of establishment or maintenance of cell polarity +
                                is-aregulation of extracellular matrix organization +
                                is-aregulation of fibril organization +
                                is-aregulation of flocculation +
                                is-aregulation of fungal-type cell wall biogenesis +
                                is-aregulation of fungal-type cell wall organization +
                                is-aregulation of fusion of sperm to egg plasma membrane +
                                is-aregulation of gene silencing +
                                is-aregulation of integrin biosynthetic process +
                                is-aregulation of ligand-dependent nuclear receptor transcription coactivator activity +
                                is-aregulation of membrane depolarization +
                                is-aregulation of membrane disassembly +
                                is-aregulation of microtubule-based process +
                                is-aregulation of myelination +
                                is-aregulation of organelle organization +
                                is-aregulation of phenotypic switching +
                                is-aregulation of phospholipid scramblase activity +
                                is-aregulation of phospholipid translocation +
                                is-aregulation of plant-type cell wall organization or biogenesis
                                is-aregulation of postsynaptic membrane organization +
                                is-aregulation of presynaptic membrane organization +
                                is-aregulation of protein complex disassembly +
                                is-aregulation of response to cell cycle checkpoint signaling +
                                is-aregulation of secondary cell wall biogenesis +
                                is-aregulation of sequestering of calcium ion +
                                is-aregulation of sequestering of zinc ion +
                                is-aregulation of single-species biofilm formation +
                                is-aregulation of stomatal movement +
                                is-aregulation of synapse organization +
                                is-aregulation of synaptic vesicle membrane organization +
                                is-aregulation of syncytium formation by plasma membrane fusion +
                                is-aregulation of transmembrane transport +
                                is-aregulation of transposition +
                                is-aregulation of ubiquitin homeostasis +
                                is-aregulation of vesicle-mediated transport +
                                is-aregulation of viral process +
                                is-asignal transduction [GO:0007165] (5409 genes, 13788 annotations)
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        is-aaxon target recognition
                                        is-acell communication by chemical coupling +
                                        is-acell communication by electrical coupling +
                                        is-acell communication involved in cardiac conduction +
                                        is-acell-cell signaling +
                                        is-acellular response to extracellular stimulus +
                                        is-aextracellular matrix-cell signaling +
                                        is-amotogenic signaling initiating cell movement in cerebral cortex +
                                        is-amotogenic signaling involved in interneuron migration from the subpallium to the cortex
                                        is-amotogenic signaling involved in postnatal olfactory bulb interneuron migration
                                        negatively-regulatesnegative regulation of cell communication +
                                        is-apollen-pistil interaction +
                                        positively-regulatespositive regulation of cell communication +
                                        is-aregulation of basal lamina disassembly involved in semicircular canal fusion by cell communication
                                        regulatesregulation of cell communication +
                                        is-aresponse to pheromone involved in conjugation with mutual genetic exchange +
                                        is-asex determination, somatic-gonadal interaction
                                        part-ofsignal transduction [GO:0007165] (5409 genes, 13788 annotations)
                                                is-aapoptotic signaling pathway +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphosphorelay signal transduction system +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in regulation of gene expression
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +
                                        part-oftransmission of nerve impulse +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-acell redox homeostasis
                                is-amodulation by symbiont of host cellular process +
                                is-amodulation of symbiont cell wall strengthening involved in entry into host +
                                is-anegative regulation of cellular process +
                                is-apositive regulation of cellular process +
                                is-aregulation of actin filament-based process +
                                is-aregulation of barbed-end actin filament capping +
                                is-aregulation of binding of sperm to zona pellucida +
                                is-aregulation of blood microparticle formation +
                                is-aregulation of capsule organization +
                                is-aregulation of cell activation +
                                is-aregulation of cell adhesion +
                                is-aregulation of cell adhesion molecule production +
                                is-aregulation of cell aging +
                                is-aregulation of cell communication +
                                is-aregulation of cell cycle +
                                is-aregulation of cell death +
                                is-aregulation of cell differentiation +
                                is-aregulation of cell division +
                                is-aregulation of cell growth +
                                is-aregulation of cell junction assembly +
                                is-aregulation of cell morphogenesis +
                                is-aregulation of cell projection organization +
                                is-aregulation of cell proliferation +
                                is-aregulation of cell wall pectin metabolic process
                                is-aregulation of cellular component movement +
                                is-aregulation of cellular localization +
                                is-aregulation of cellular metabolic process +
                                is-aregulation of cellular pH reduction +
                                is-aregulation of cellular response to alkalinity +
                                is-aregulation of cellular response to drug +
                                is-aregulation of cellular response to growth factor stimulus +
                                is-aregulation of cellular response to insulin stimulus +
                                is-aregulation of cellular response to stress +
                                is-aregulation of cellular response to testosterone stimulus +
                                is-aregulation of cellular response to X-ray +
                                is-aregulation of chromosome segregation +
                                is-aregulation of conjugation +
                                is-aregulation of dendritic spine maintenance +
                                is-aregulation of dynamin polymerization involved in membrane fission
                                is-aregulation of establishment or maintenance of cell polarity +
                                is-aregulation of extracellular matrix organization +
                                is-aregulation of fibril organization +
                                is-aregulation of flocculation +
                                is-aregulation of fungal-type cell wall biogenesis +
                                is-aregulation of fungal-type cell wall organization +
                                is-aregulation of fusion of sperm to egg plasma membrane +
                                is-aregulation of gene silencing +
                                is-aregulation of integrin biosynthetic process +
                                is-aregulation of ligand-dependent nuclear receptor transcription coactivator activity +
                                is-aregulation of membrane depolarization +
                                is-aregulation of membrane disassembly +
                                is-aregulation of microtubule-based process +
                                is-aregulation of myelination +
                                is-aregulation of organelle organization +
                                is-aregulation of phenotypic switching +
                                is-aregulation of phospholipid scramblase activity +
                                is-aregulation of phospholipid translocation +
                                is-aregulation of plant-type cell wall organization or biogenesis
                                is-aregulation of postsynaptic membrane organization +
                                is-aregulation of presynaptic membrane organization +
                                is-aregulation of protein complex disassembly +
                                is-aregulation of response to cell cycle checkpoint signaling +
                                is-aregulation of secondary cell wall biogenesis +
                                is-aregulation of sequestering of calcium ion +
                                is-aregulation of sequestering of zinc ion +
                                is-aregulation of single-species biofilm formation +
                                is-aregulation of stomatal movement +
                                is-aregulation of synapse organization +
                                is-aregulation of synaptic vesicle membrane organization +
                                is-aregulation of syncytium formation by plasma membrane fusion +
                                is-aregulation of transmembrane transport +
                                is-aregulation of transposition +
                                is-aregulation of ubiquitin homeostasis +
                                is-aregulation of vesicle-mediated transport +
                                is-aregulation of viral process +
                                is-asignal transduction [GO:0007165] (5409 genes, 13788 annotations)
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular pigment accumulation +
                                is-acellular response to abiotic stimulus +
                                is-acellular response to biotic stimulus +
                                is-acellular response to cell wall damage
                                is-acellular response to chemical stimulus +
                                is-acellular response to extracellular stimulus +
                                is-acellular response to stress +
                                is-asignal transduction [GO:0007165] (5409 genes, 13788 annotations)
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +
                                is-askeletal muscle fiber adaptation


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                is-acell-cell signaling +
                                is-aextracellular matrix-cell signaling +
                                is-amotogenic signaling initiating cell movement in cerebral cortex +
                                is-amotogenic signaling involved in interneuron migration from the subpallium to the cortex
                                is-amotogenic signaling involved in postnatal olfactory bulb interneuron migration
                                is-amulticellular organismal signaling +
                                negatively-regulatesnegative regulation of signaling +
                                positively-regulatespositive regulation of signaling +
                                regulatesregulation of signaling +
                                part-ofsignal transduction [GO:0007165] (5409 genes, 13788 annotations)
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                is-acell-cell signaling +
                                is-aextracellular matrix-cell signaling +
                                is-amotogenic signaling initiating cell movement in cerebral cortex +
                                is-amotogenic signaling involved in interneuron migration from the subpallium to the cortex
                                is-amotogenic signaling involved in postnatal olfactory bulb interneuron migration
                                is-amulticellular organismal signaling +
                                negatively-regulatesnegative regulation of signaling +
                                positively-regulatespositive regulation of signaling +
                                regulatesregulation of signaling +
                                part-ofsignal transduction [GO:0007165] (5409 genes, 13788 annotations)
                                        is-aapoptotic signaling pathway +
                                        is-abile acid signaling pathway +
                                        is-acarbohydrate mediated signaling +
                                        is-acell surface receptor signaling pathway +
                                        is-achloroplast-nucleus signaling pathway
                                        is-adefense response signaling pathway, resistance gene-dependent
                                        is-adefense response signaling pathway, resistance gene-independent
                                        is-aER-nucleus signaling pathway +
                                        is-ahormone-mediated signaling pathway +
                                        is-ahydrogen peroxide mediated signaling pathway +
                                        is-ahypoxia-inducible factor-1alpha signaling pathway +
                                        is-aimmune response-regulating signaling pathway +
                                        is-aintracellular receptor signaling pathway +
                                        is-aintracellular signal transduction +
                                        is-alipoprotein particle mediated signaling +
                                        is-amitochondria-nucleus signaling pathway
                                        is-anecroptotic signaling pathway
                                        negatively-regulatesnegative regulation of signal transduction +
                                        is-aneuronal signal transduction +
                                        is-aosmosensory signaling pathway +
                                        is-aphosphorelay signal transduction system +
                                        is-aphototransduction +
                                        positively-regulatespositive regulation of signal transduction +
                                        is-ared or far-red light signaling pathway +
                                        is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                        is-aregulation of floral organ abscission by signal transduction +
                                        regulatesregulation of signal transduction +
                                        is-asalicylic acid mediated signaling pathway +
                                        is-asignal transduction by conformational transition
                                        is-asignal transduction by phosphorylation +
                                        is-asignal transduction in absence of ligand +
                                        is-asignal transduction involved in conjugation with cellular fusion +
                                        is-asignal transduction involved in Dma1-dependent checkpoint
                                        is-asignal transduction involved in filamentous growth
                                        is-asignal transduction involved in regulation of gene expression
                                        is-aSMAD protein signal transduction
                                        is-asphingolipid mediated signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        is-aaxon target recognition
                                        is-acell communication by chemical coupling +
                                        is-acell communication by electrical coupling +
                                        is-acell communication involved in cardiac conduction +
                                        is-acell-cell signaling +
                                        is-acellular response to extracellular stimulus +
                                        is-aextracellular matrix-cell signaling +
                                        is-amotogenic signaling initiating cell movement in cerebral cortex +
                                        is-amotogenic signaling involved in interneuron migration from the subpallium to the cortex
                                        is-amotogenic signaling involved in postnatal olfactory bulb interneuron migration
                                        negatively-regulatesnegative regulation of cell communication +
                                        is-apollen-pistil interaction +
                                        positively-regulatespositive regulation of cell communication +
                                        is-aregulation of basal lamina disassembly involved in semicircular canal fusion by cell communication
                                        regulatesregulation of cell communication +
                                        is-aresponse to pheromone involved in conjugation with mutual genetic exchange +
                                        is-asex determination, somatic-gonadal interaction
                                        part-ofsignal transduction [GO:0007165] (5409 genes, 13788 annotations)
                                                is-aapoptotic signaling pathway +
                                                is-abile acid signaling pathway +
                                                is-acarbohydrate mediated signaling +
                                                is-acell surface receptor signaling pathway +
                                                is-achloroplast-nucleus signaling pathway
                                                is-adefense response signaling pathway, resistance gene-dependent
                                                is-adefense response signaling pathway, resistance gene-independent
                                                is-aER-nucleus signaling pathway +
                                                is-ahormone-mediated signaling pathway +
                                                is-ahydrogen peroxide mediated signaling pathway +
                                                is-ahypoxia-inducible factor-1alpha signaling pathway +
                                                is-aimmune response-regulating signaling pathway +
                                                is-aintracellular receptor signaling pathway +
                                                is-aintracellular signal transduction +
                                                is-alipoprotein particle mediated signaling +
                                                is-amitochondria-nucleus signaling pathway
                                                is-anecroptotic signaling pathway
                                                negatively-regulatesnegative regulation of signal transduction +
                                                is-aneuronal signal transduction +
                                                is-aosmosensory signaling pathway +
                                                is-aphosphorelay signal transduction system +
                                                is-aphototransduction +
                                                positively-regulatespositive regulation of signal transduction +
                                                is-ared or far-red light signaling pathway +
                                                is-aregulation of blood pressure by chemoreceptor signaling pathway +
                                                is-aregulation of floral organ abscission by signal transduction +
                                                regulatesregulation of signal transduction +
                                                is-asalicylic acid mediated signaling pathway +
                                                is-asignal transduction by conformational transition
                                                is-asignal transduction by phosphorylation +
                                                is-asignal transduction in absence of ligand +
                                                is-asignal transduction involved in conjugation with cellular fusion +
                                                is-asignal transduction involved in Dma1-dependent checkpoint
                                                is-asignal transduction involved in filamentous growth
                                                is-asignal transduction involved in regulation of gene expression
                                                is-aSMAD protein signal transduction
                                                is-asphingolipid mediated signaling pathway +
                                        part-oftransmission of nerve impulse +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory