Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes INS
  • Mouse genes Ins2
  • Rat genes Ins2
  • Zfish genes ins,insb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ins2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005179	hormone activity	INS	IMP		Human	PMID:381941
Molecular Function	GO:0042802	identical protein binding	INS	IPI	UniProtKB:P01308	Human	PMID:17472440
Molecular Function	GO:0042802	identical protein binding	INS	IPI	UniProtKB:P01308	Human	PMID:20738396
Molecular Function	GO:0042802	identical protein binding	INS	IPI	UniProtKB:P01308	Human	PMID:22854022
Molecular Function	GO:0042802	identical protein binding	INS	IPI	UniProtKB:P01308	Human	PMID:23106816
Molecular Function	GO:0042802	identical protein binding	INS	IPI	UniProtKB:P01308	Human	PMID:23416304
Molecular Function	GO:0042802	identical protein binding	INS	IPI	UniProtKB:P01308	Human	PMID:23510797
Molecular Function	GO:0005158	insulin receptor binding	INS	IDA		Human	PMID:7556975
Molecular Function	GO:0005158	insulin receptor binding	INS	IPI	UniProtKB:P06213	Human	PMID:8452530
Molecular Function	GO:0005158	insulin receptor binding	INS	IDA		Human	PMID:9667398
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	INS	IPI	UniProtKB:P08069	Human	PMID:8452530
Molecular Function	GO:0002020	protease binding	INS	IPI	UniProtKB:P14735	Human	PMID:20082125
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:P14735-1	Human	PMID:17051221
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:P06213-2	Human	PMID:23302862
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:P06213-2	Human	PMID:29512653
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:Q6UY14-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:P17936	Human	PMID:9388210
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:Q16270	Human	PMID:9388210
Molecular Function	GO:0005515	protein binding	INS	IPI	UniProtKB:P98164	Human	PMID:9773776
Molecular Function	GO:0008270	zinc ion binding	Ins2	IGI	MGI:MGI:2442682	Mouse	PMID:20424817
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Ins2	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	Ins2	IDA		Mouse	PMID:15793245
Cellular Component	GO:0005829	cytosol	Ins2	IDA		Mouse	PMID:21828338
Cellular Component	GO:0005615	extracellular space	INS	IDA		Human	PMID:9667398
Cellular Component	GO:0005615	extracellular space	Ins2	IDA		Mouse	PMID:27055260
Cellular Component	GO:0005615	extracellular space	Ins2	IDA		Mouse	PMID:9452465
Cellular Component	GO:0005615	extracellular space	Ins2	IDA		Rat	PMID:12475375|RGD:2298715
Cellular Component	GO:0005634	nucleus	Ins2	IDA		Mouse	PMID:12488434
Cellular Component	GO:0030141	secretory granule	Ins2	IDA		Mouse	PMID:15788565
Cellular Component	GO:0030141	secretory granule	Ins2	IDA		Rat	PMID:7822759|RGD:2308908
Cellular Component	GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	Ins2	IDA		Mouse	PMID:12488434
Biological Process	GO:0032148	activation of protein kinase B activity	INS	IDA		Human	PMID:8702995
Biological Process	GO:0006953	acute-phase response	INS	IDA		Human	PMID:14739855
Biological Process	GO:0046631	alpha-beta T cell activation	INS	IDA		Human	PMID:10604997
Biological Process	GO:0006983	ER overload response	Ins2	IMP	MGI:MGI:1857572	Mouse	PMID:11854325
Biological Process	GO:0055089	fatty acid homeostasis	INS	IMP		Human	PMID:1184755
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	INS	IDA		Human	PMID:9092559
Biological Process	GO:0042593	glucose homeostasis	INS	IMP		Human	PMID:381941
Biological Process	GO:0042593	glucose homeostasis	Ins2	IMP	MGI:MGI:1857572	Mouse	PMID:23274896
Biological Process	GO:0006006	glucose metabolic process	Ins2	IMP	MGI:MGI:1857572	Mouse	PMID:11854325
Biological Process	GO:0030070	insulin processing	Ins2	IGI	MGI:MGI:2442682	Mouse	PMID:20424817
Biological Process	GO:0008286	insulin receptor signaling pathway	INS	IDA		Human	PMID:20455999
Biological Process	GO:0008286	insulin receptor signaling pathway	Ins2	IMP	MGI:MGI:2181878	Mouse	PMID:20056832
Biological Process	GO:0008286	insulin receptor signaling pathway	Ins2	IDA		Mouse	PMID:12805218
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Ins2	IMP	MGI:MGI:1857572	Mouse	PMID:11854325
Biological Process	GO:0016042	lipid catabolic process	Ins2	IDA		Mouse	PMID:12805218
Biological Process	GO:0007520	myoblast fusion	Ins2	IGI	MGI:MGI:1861437	Mouse	PMID:15282335
Biological Process	GO:0007520	myoblast fusion	Ins2	IGI	MGI:MGI:98953	Mouse	PMID:15282335
Biological Process	GO:0014902	myotube differentiation	Ins2	IGI	MGI:MGI:1861437	Mouse	PMID:15282335
Biological Process	GO:0014902	myotube differentiation	Ins2	IGI	MGI:MGI:98953	Mouse	PMID:15282335
Biological Process	GO:0002674	negative regulation of acute inflammatory response	INS	IDA		Human	PMID:11443198
Biological Process	GO:0045922	negative regulation of fatty acid metabolic process	INS	IMP		Human	PMID:1184755
Biological Process	GO:2000252	negative regulation of feeding behavior	INS	IDA		Human	PMID:17957153
Biological Process	GO:2000252	negative regulation of feeding behavior	ins	IMP	ZFIN:ZDB-MRPHLNO-130312-4	Zfish	PMID:23300705
Biological Process	GO:0010629	negative regulation of gene expression	INS	IDA		Human	PMID:31501273
Biological Process	GO:0045818	negative regulation of glycogen catabolic process	INS	IMP		Human	PMID:381941
Biological Process	GO:0050995	negative regulation of lipid catabolic process	INS	IMP		Human	PMID:24675707
Biological Process	GO:0033861	negative regulation of NAD(P)H oxidase activity	INS	IDA		Human	PMID:11443198
Biological Process	GO:0042177	negative regulation of protein catabolic process	INS	IDA		Human	PMID:15185208
Biological Process	GO:0050709	negative regulation of protein secretion	INS	IDA		Human	PMID:14739855
Biological Process	GO:0045861	negative regulation of proteolysis	INS	IMP		Human	PMID:3553851
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	INS	IGI	ComplexPortal:CPX-1134	Human	PMID:19188609
Biological Process	GO:0060266	negative regulation of respiratory burst involved in inflammatory response	INS	IDA		Human	PMID:11443198
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ins2	IDA		Mouse	PMID:9689059
Biological Process	GO:1990535	neuron projection maintenance	INS	IGI	ComplexPortal:CPX-1134,UniProtKB:P15127	Human	PMID:19188609
Biological Process	GO:0038060	nitric oxide-cGMP-mediated signaling pathway	INS	IDA		Human	PMID:14744991
Biological Process	GO:0008284	positive regulation of cell population proliferation	INS	IDA		Human	PMID:17925406
Biological Process	GO:0008284	positive regulation of cell population proliferation	INS	IDA		Human	PMID:7688386
Biological Process	GO:0001819	positive regulation of cytokine production	INS	IDA		Human	PMID:15473891
Biological Process	GO:1902952	positive regulation of dendritic spine maintenance	INS	IGI	ComplexPortal:CPX-1134	Human	PMID:19188609
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Ins2	IDA		Mouse	PMID:12059784
Biological Process	GO:0010628	positive regulation of gene expression	INS	IGI	RNAcentral:URS00004AD914_9606,RNAcentral:URS00004BCD9C_9606	Human	PMID:25403480
Biological Process	GO:0046326	positive regulation of glucose import	INS	IDA		Human	PMID:14615391
Biological Process	GO:0046326	positive regulation of glucose import	INS	IMP		Human	PMID:14615391
Biological Process	GO:0046326	positive regulation of glucose import	INS	IDA		Human	PMID:15792832
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	INS	IDA		Human	PMID:17925406
Biological Process	GO:0045821	positive regulation of glycolytic process	INS	IMP		Human	PMID:381941
Biological Process	GO:0045821	positive regulation of glycolytic process	INS	IDA		Human	PMID:7688386
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	INS	IMP		Human	PMID:14615391
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	INS	IDA		Human	PMID:15792832
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	INS	IDA		Human	PMID:7688386
Biological Process	GO:0043410	positive regulation of MAPK cascade	INS	IDA		Human	PMID:11500939
Biological Process	GO:0043410	positive regulation of MAPK cascade	INS	IDA		Human	PMID:20455999
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	INS	IDA		Human	PMID:10644978
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	INS	IDA		Human	PMID:11500939
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	INS	IDA		Human	PMID:19727662
Biological Process	GO:0010750	positive regulation of nitric oxide mediated signal transduction	INS	IMP		Human	PMID:14615391
Biological Process	GO:0010750	positive regulation of nitric oxide mediated signal transduction	INS	IDA		Human	PMID:15792832
Biological Process	GO:2000228	positive regulation of pancreatic A cell differentiation	ins	IMP	ZFIN:ZDB-MRPHLNO-160331-1	Zfish	PMID:26658317
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Ins2	IDA		Mouse	PMID:23775122
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	Ins2	IDA		Mouse	PMID:11375348
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	INS	IDA		Human	PMID:7688386
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	INS	IDA		Human	PMID:11500939
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	INS	IDA		Human	PMID:25240198
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	INS	IDA		Human	PMID:20455999
Biological Process	GO:0051247	positive regulation of protein metabolic process	INS	IMP		Human	PMID:3553851
Biological Process	GO:0060267	positive regulation of respiratory burst	INS	IDA		Human	PMID:9092559
Biological Process	GO:0031623	receptor internalization	Ins2	IDA		Mouse	PMID:17264162
Biological Process	GO:0006521	regulation of cellular amino acid metabolic process	INS	IMP		Human	PMID:3553851
Biological Process	GO:0010468	regulation of gene expression	Ins2	IDA		Mouse	PMID:19293336
Biological Process	GO:0042325	regulation of phosphorylation	Ins2	IDA		Mouse	PMID:12059784
Biological Process	GO:0043393	regulation of protein binding	Ins2	IDA		Mouse	PMID:9507006
Biological Process	GO:0032880	regulation of protein localization	INS	IDA		Human	PMID:14615391
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	INS	IGI	ComplexPortal:CPX-1134	Human	PMID:19188609
Biological Process	GO:0050708	regulation of protein secretion	INS	IDA		Human	PMID:15591776
Biological Process	GO:0022898	regulation of transmembrane transporter activity	INS	IDA		Human	PMID:14615391
Biological Process	GO:0009749	response to glucose	ins	IDA		Zfish	PMID:17446233
Biological Process	GO:0031667	response to nutrient levels	ins	IDA		Zfish	PMID:19793957
Biological Process	GO:0003309	type B pancreatic cell differentiation	ins	IMP	ZFIN:ZDB-MRPHLNO-160331-1	Zfish	PMID:26658317
Biological Process	GO:0042311	vasodilation	INS	IDA		Human	PMID:14744991
Biological Process	GO:0042060	wound healing	INS	IDA		Human	PMID:9498508

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern