| GO term: | receptor internalization |
| GO id: | GO:0031623 |
| Definition: | A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. |
| Number of paths to term: | 8 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processcellular metabolic processcellular macromolecule metabolic processreceptor metabolic processlow-density lipoprotein receptor particle metabolic process +neurotransmitter receptor metabolic process +receptor biosynthetic process +receptor catabolic process +receptor internalization [GO:0031623] (56 genes, 65 annotations)B cell receptor internalization +G-protein coupled receptor internalizationinsulin receptor internalization +negative regulation of receptor internalizationpositive regulation of receptor internalizationreceptor internalization involved in canonical Wnt receptor signaling pathwayregulation of receptor internalization +regulation of signal transduction by receptor internalization +Wnt receptor internalization +receptor recycling +biological_processestablishment of localizationtransportsingle-organism transport2-aminoethylphosphonate transportacetate ester transport +alkane transportamide transport +amine transport +carbohydrate derivative transport +carbohydrate transport +cargo loading into vesicle +caveolin-mediated endocytosis +chaperone-mediated protein transport +clathrin-mediated endocytosis +cofactor transport +cutin transportcytoplasmic transport, nurse cell to oocyte +cytoskeleton-dependent intracellular transport +cytosol to ER transportDNA import into cell involved in transformationdrug transport +dsRNA transportendosomal transport +establishment of protein localization to mast cell secretory granule +establishment of protein localization to T cell secretory granule +eye pigment precursor transportfatty acid derivative transport +fatty-acyl group transportfluid transport +gas transport +glycoside transport +Golgi to secretory granule transportGolgi to transport vesicle transportGolgi vesicle transport +hormone transport +hydrogen transport +intercellular transport +intermembrane transportion transport +iron coordination entity transport +lactone transportlipid hydroperoxide transportlipid transport +lipoprotein transportmembrane budding +misfolded protein transport +mitochondrial transport +monoamine transport +mRNA export from nucleus in response to heat stress +multivesicular body sorting pathwayncRNA export from nucleusneurotransmitter transport +nitric oxide transportnuclear import +nucleobase transport +nucleolus to nucleoplasm transportone-carbon compound transport +organic acid transport +organic hydroxy compound transport +organic phosphonate transport +organophosphate ester transport +ovarian nurse cell to oocyte transport +peroxisomal transport +phagocytosis +pigment granule transport +pinocytosis +poly(A)+ mRNA export from nucleuspolyamine transport +polyubiquitinated protein transport +pre-miRNA export from nucleusprotein exit from endoplasmic reticulum +protein export from nucleus +protein import +protein import into nucleus, translocation +protein targeting +protein transport across periplasmic space +protein transport within extracellular regionprotein transport within lipid bilayer +protein-DNA complex transportquaternary ammonium group transport +receptor internalization [GO:0031623] (56 genes, 65 annotations)B cell receptor internalization +G-protein coupled receptor internalizationinsulin receptor internalization +negative regulation of receptor internalizationpositive regulation of receptor internalizationreceptor internalization involved in canonical Wnt receptor signaling pathwayregulation of receptor internalization +regulation of signal transduction by receptor internalization +Wnt receptor internalization +receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportretrograde protein transport, ER to cytosolretrograde transport, plasma membrane to GolgirRNA transport +secretion +silicic acid transportsnRNA transport +sperm entrysulfur compound transport +synaptic vesicle transport +thioester transport +transcytosis +transepithelial transport +transmembrane transport +tRNA transport +ubiquitin-dependent endocytosis +vacuolar transport +vascular transport +vesicle-mediated transport involved in floral organ abscission +vitamin transport +xenobiotic transport +biological_processestablishment of localizationtransportvesicle-mediated transportendocytosisreceptor-mediated endocytosiscaveolin-mediated endocytosis +clathrin-mediated endocytosis +negative regulation of receptor-mediated endocytosis +positive regulation of receptor-mediated endocytosis +receptor internalization [GO:0031623] (56 genes, 65 annotations)B cell receptor internalization +G-protein coupled receptor internalizationinsulin receptor internalization +negative regulation of receptor internalizationpositive regulation of receptor internalizationreceptor internalization involved in canonical Wnt receptor signaling pathwayregulation of receptor internalization +regulation of signal transduction by receptor internalization +Wnt receptor internalization +receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportregulation of receptor-mediated endocytosis +viral entry into host cell via receptor-mediated endocytosis +biological_processlocalizationestablishment of localizationtransportsingle-organism transport2-aminoethylphosphonate transportacetate ester transport +alkane transportamide transport +amine transport +carbohydrate derivative transport +carbohydrate transport +cargo loading into vesicle +caveolin-mediated endocytosis +chaperone-mediated protein transport +clathrin-mediated endocytosis +cofactor transport +cutin transportcytoplasmic transport, nurse cell to oocyte +cytoskeleton-dependent intracellular transport +cytosol to ER transportDNA import into cell involved in transformationdrug transport +dsRNA transportendosomal transport +establishment of protein localization to mast cell secretory granule +establishment of protein localization to T cell secretory granule +eye pigment precursor transportfatty acid derivative transport +fatty-acyl group transportfluid transport +gas transport +glycoside transport +Golgi to secretory granule transportGolgi to transport vesicle transportGolgi vesicle transport +hormone transport +hydrogen transport +intercellular transport +intermembrane transportion transport +iron coordination entity transport +lactone transportlipid hydroperoxide transportlipid transport +lipoprotein transportmembrane budding +misfolded protein transport +mitochondrial transport +monoamine transport +mRNA export from nucleus in response to heat stress +multivesicular body sorting pathwayncRNA export from nucleusneurotransmitter transport +nitric oxide transportnuclear import +nucleobase transport +nucleolus to nucleoplasm transportone-carbon compound transport +organic acid transport +organic hydroxy compound transport +organic phosphonate transport +organophosphate ester transport +ovarian nurse cell to oocyte transport +peroxisomal transport +phagocytosis +pigment granule transport +pinocytosis +poly(A)+ mRNA export from nucleuspolyamine transport +polyubiquitinated protein transport +pre-miRNA export from nucleusprotein exit from endoplasmic reticulum +protein export from nucleus +protein import +protein import into nucleus, translocation +protein targeting +protein transport across periplasmic space +protein transport within extracellular regionprotein transport within lipid bilayer +protein-DNA complex transportquaternary ammonium group transport +receptor internalization [GO:0031623] (56 genes, 65 annotations)B cell receptor internalization +G-protein coupled receptor internalizationinsulin receptor internalization +negative regulation of receptor internalizationpositive regulation of receptor internalizationreceptor internalization involved in canonical Wnt receptor signaling pathwayregulation of receptor internalization +regulation of signal transduction by receptor internalization +Wnt receptor internalization +receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportretrograde protein transport, ER to cytosolretrograde transport, plasma membrane to GolgirRNA transport +secretion +silicic acid transportsnRNA transport +sperm entrysulfur compound transport +synaptic vesicle transport +thioester transport +transcytosis +transepithelial transport +transmembrane transport +tRNA transport +ubiquitin-dependent endocytosis +vacuolar transport +vascular transport +vesicle-mediated transport involved in floral organ abscission +vitamin transport +xenobiotic transport +biological_processlocalizationestablishment of localizationtransportvesicle-mediated transportendocytosisreceptor-mediated endocytosiscaveolin-mediated endocytosis +clathrin-mediated endocytosis +negative regulation of receptor-mediated endocytosis +positive regulation of receptor-mediated endocytosis +receptor internalization [GO:0031623] (56 genes, 65 annotations)B cell receptor internalization +G-protein coupled receptor internalizationinsulin receptor internalization +negative regulation of receptor internalizationpositive regulation of receptor internalizationreceptor internalization involved in canonical Wnt receptor signaling pathwayregulation of receptor internalization +regulation of signal transduction by receptor internalization +Wnt receptor internalization +receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportregulation of receptor-mediated endocytosis +viral entry into host cell via receptor-mediated endocytosis +biological_processmetabolic processcellular metabolic processcellular macromolecule metabolic processreceptor metabolic processlow-density lipoprotein receptor particle metabolic process +neurotransmitter receptor metabolic process +receptor biosynthetic process +receptor catabolic process +receptor internalization [GO:0031623] (56 genes, 65 annotations)B cell receptor internalization +G-protein coupled receptor internalizationinsulin receptor internalization +negative regulation of receptor internalizationpositive regulation of receptor internalizationreceptor internalization involved in canonical Wnt receptor signaling pathwayregulation of receptor internalization +regulation of signal transduction by receptor internalization +Wnt receptor internalization +receptor recycling +biological_processmetabolic processorganic substance metabolic processmacromolecule metabolic processcellular macromolecule metabolic processreceptor metabolic processlow-density lipoprotein receptor particle metabolic process +neurotransmitter receptor metabolic process +receptor biosynthetic process +receptor catabolic process +receptor internalization [GO:0031623] (56 genes, 65 annotations)B cell receptor internalization +G-protein coupled receptor internalizationinsulin receptor internalization +negative regulation of receptor internalizationpositive regulation of receptor internalizationreceptor internalization involved in canonical Wnt receptor signaling pathwayregulation of receptor internalization +regulation of signal transduction by receptor internalization +Wnt receptor internalization +receptor recycling +biological_processsingle-organism processsingle-organism transport2-aminoethylphosphonate transportacetate ester transport +alkane transportamide transport +amine transport +carbohydrate derivative transport +carbohydrate transport +cargo loading into vesicle +caveolin-mediated endocytosis +chaperone-mediated protein transport +clathrin-mediated endocytosis +cofactor transport +cutin transportcytoplasmic transport, nurse cell to oocyte +cytoskeleton-dependent intracellular transport +cytosol to ER transportDNA import into cell involved in transformationdrug transport +dsRNA transportendosomal transport +establishment of protein localization to mast cell secretory granule +establishment of protein localization to T cell secretory granule +eye pigment precursor transportfatty acid derivative transport +fatty-acyl group transportfluid transport +gas transport +glycoside transport +Golgi to secretory granule transportGolgi to transport vesicle transportGolgi vesicle transport +hormone transport +hydrogen transport +intercellular transport +intermembrane transportion transport +iron coordination entity transport +lactone transportlipid hydroperoxide transportlipid transport +lipoprotein transportmembrane budding +misfolded protein transport +mitochondrial transport +monoamine transport +mRNA export from nucleus in response to heat stress +multivesicular body sorting pathwayncRNA export from nucleusneurotransmitter transport +nitric oxide transportnuclear import +nucleobase transport +nucleolus to nucleoplasm transportone-carbon compound transport +organic acid transport +organic hydroxy compound transport +organic phosphonate transport +organophosphate ester transport +ovarian nurse cell to oocyte transport +peroxisomal transport +phagocytosis +pigment granule transport +pinocytosis +poly(A)+ mRNA export from nucleuspolyamine transport +polyubiquitinated protein transport +pre-miRNA export from nucleusprotein exit from endoplasmic reticulum +protein export from nucleus +protein import +protein import into nucleus, translocation +protein targeting +protein transport across periplasmic space +protein transport within extracellular regionprotein transport within lipid bilayer +protein-DNA complex transportquaternary ammonium group transport +receptor internalization [GO:0031623] (56 genes, 65 annotations)B cell receptor internalization +G-protein coupled receptor internalizationinsulin receptor internalization +negative regulation of receptor internalizationpositive regulation of receptor internalizationreceptor internalization involved in canonical Wnt receptor signaling pathwayregulation of receptor internalization +regulation of signal transduction by receptor internalization +Wnt receptor internalization +receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportretrograde protein transport, ER to cytosolretrograde transport, plasma membrane to GolgirRNA transport +secretion +silicic acid transportsnRNA transport +sperm entrysulfur compound transport +synaptic vesicle transport +thioester transport +transcytosis +transepithelial transport +transmembrane transport +tRNA transport +ubiquitin-dependent endocytosis +vacuolar transport +vascular transport +vesicle-mediated transport involved in floral organ abscission +vitamin transport +xenobiotic transport +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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