About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:G-protein coupled receptor signaling pathway
Synonym: GPCR signaling pathway
Synonym: GPCR signalling pathway
Synonym: G protein coupled receptor protein signaling pathway
Synonym: G-protein coupled receptor protein signaling pathway
Synonym: G-protein-coupled receptor protein signaling pathway
Synonym: G protein coupled receptor protein signalling pathway
Synonym: G-protein-coupled receptor protein signalling pathway
Synonym: G-protein coupled receptor protein signal transduction
Synonym: G-protein coupled receptor signalling pathway
GO id:GO:0007186
Definition:A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
Number of paths to term: 9

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aanti-Mullerian hormone signaling pathway +
                                                        is-aapolipoprotein A-I-mediated signaling pathway
                                                        is-aCD40 signaling pathway +
                                                        is-acell surface bile acid receptor signaling pathway
                                                        is-acell surface receptor signaling pathway involved in heart development +
                                                        is-acollagen-activated signaling pathway +
                                                        is-acytokine-mediated signaling pathway +
                                                        is-aenzyme linked receptor protein signaling pathway +
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-aFas signaling pathway +
                                                        is-aG-protein coupled receptor signaling pathway [GO:0007186] (2100 genes, 2743 annotations)
                                                                is-aadrenergic receptor signaling pathway +
                                                                is-aangiotensin-activated signaling pathway +
                                                                is-aapelin receptor signaling pathway
                                                                is-abombesin receptor signaling pathway
                                                                is-acalcitonin family receptor signaling pathway +
                                                                is-acannabinoid signaling pathway +
                                                                is-acholecystokinin signaling pathway +
                                                                is-acomplement component C5a signaling pathway
                                                                is-adimeric G-protein coupled receptor signaling pathway +
                                                                is-adopamine receptor signaling pathway +
                                                                is-aendothelin receptor signaling pathway +
                                                                is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                                is-afollicle-stimulating hormone signaling pathway
                                                                is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                                is-aG-protein coupled glutamate receptor signaling pathway +
                                                                is-aG-protein coupled purinergic receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling in absence of ligand
                                                                is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                                is-agamma-aminobutyric acid signaling pathway
                                                                is-agastric inhibitory peptide signaling pathway
                                                                part-ofheterotrimeric G-protein complex cycle
                                                                is-aluteinizing hormone signaling pathway +
                                                                negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aneuropeptide signaling pathway
                                                                is-aoctopamine or tyramine signaling pathway +
                                                                is-aopioid receptor signaling pathway +
                                                                is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                                is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                                is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                                is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                                positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                                regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                                is-arhodopsin mediated signaling pathway +
                                                                is-aserotonin receptor signaling pathway +
                                                                is-asignal transduction involved in conjugation with mutual genetic exchange
                                                                is-asomatostatin receptor signaling pathway +
                                                                is-asphingosine-1-phosphate signaling pathway +
                                                                is-atachykinin receptor signaling pathway +
                                                                is-athrombin receptor signaling pathway +
                                                                is-athromboxane A2 signaling pathway
                                                                is-athyroid-stimulating hormone signaling pathway
                                                        is-aglutamate receptor signaling pathway +
                                                        is-aimmune response-regulating cell surface receptor signaling pathway +
                                                        is-aintegrin-mediated signaling pathway +
                                                        is-alipopolysaccharide-mediated signaling pathway +
                                                        is-anetrin-activated signaling pathway +
                                                        is-aneuropilin signaling pathway +
                                                        is-aneurotrophin signaling pathway +
                                                        is-aNotch signaling pathway +
                                                        is-apeptidoglycan recognition protein signaling pathway +
                                                        is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                        is-apurinergic receptor signaling pathway +
                                                        is-areelin-mediated signaling pathway
                                                        is-aRoundabout signaling pathway +
                                                        is-asemaphorin-plexin signaling pathway +
                                                        is-asmoothened signaling pathway +
                                                        is-aToll signaling pathway +
                                                        is-aurokinase plasminogen activator signaling pathway
                                                        is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway [GO:0007186] (2100 genes, 2743 annotations)
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway +
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway [GO:0007186] (2100 genes, 2743 annotations)
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway +
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aanti-Mullerian hormone signaling pathway +
                                                        is-aapolipoprotein A-I-mediated signaling pathway
                                                        is-aCD40 signaling pathway +
                                                        is-acell surface bile acid receptor signaling pathway
                                                        is-acell surface receptor signaling pathway involved in heart development +
                                                        is-acollagen-activated signaling pathway +
                                                        is-acytokine-mediated signaling pathway +
                                                        is-aenzyme linked receptor protein signaling pathway +
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-aFas signaling pathway +
                                                        is-aG-protein coupled receptor signaling pathway [GO:0007186] (2100 genes, 2743 annotations)
                                                                is-aadrenergic receptor signaling pathway +
                                                                is-aangiotensin-activated signaling pathway +
                                                                is-aapelin receptor signaling pathway
                                                                is-abombesin receptor signaling pathway
                                                                is-acalcitonin family receptor signaling pathway +
                                                                is-acannabinoid signaling pathway +
                                                                is-acholecystokinin signaling pathway +
                                                                is-acomplement component C5a signaling pathway
                                                                is-adimeric G-protein coupled receptor signaling pathway +
                                                                is-adopamine receptor signaling pathway +
                                                                is-aendothelin receptor signaling pathway +
                                                                is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                                is-afollicle-stimulating hormone signaling pathway
                                                                is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                                is-aG-protein coupled glutamate receptor signaling pathway +
                                                                is-aG-protein coupled purinergic receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling in absence of ligand
                                                                is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                                is-agamma-aminobutyric acid signaling pathway
                                                                is-agastric inhibitory peptide signaling pathway
                                                                part-ofheterotrimeric G-protein complex cycle
                                                                is-aluteinizing hormone signaling pathway +
                                                                negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aneuropeptide signaling pathway
                                                                is-aoctopamine or tyramine signaling pathway +
                                                                is-aopioid receptor signaling pathway +
                                                                is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                                is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                                is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                                is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                                positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                                regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                                is-arhodopsin mediated signaling pathway +
                                                                is-aserotonin receptor signaling pathway +
                                                                is-asignal transduction involved in conjugation with mutual genetic exchange
                                                                is-asomatostatin receptor signaling pathway +
                                                                is-asphingosine-1-phosphate signaling pathway +
                                                                is-atachykinin receptor signaling pathway +
                                                                is-athrombin receptor signaling pathway +
                                                                is-athromboxane A2 signaling pathway
                                                                is-athyroid-stimulating hormone signaling pathway
                                                        is-aglutamate receptor signaling pathway +
                                                        is-aimmune response-regulating cell surface receptor signaling pathway +
                                                        is-aintegrin-mediated signaling pathway +
                                                        is-alipopolysaccharide-mediated signaling pathway +
                                                        is-anetrin-activated signaling pathway +
                                                        is-aneuropilin signaling pathway +
                                                        is-aneurotrophin signaling pathway +
                                                        is-aNotch signaling pathway +
                                                        is-apeptidoglycan recognition protein signaling pathway +
                                                        is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                        is-apurinergic receptor signaling pathway +
                                                        is-areelin-mediated signaling pathway
                                                        is-aRoundabout signaling pathway +
                                                        is-asemaphorin-plexin signaling pathway +
                                                        is-asmoothened signaling pathway +
                                                        is-aToll signaling pathway +
                                                        is-aurokinase plasminogen activator signaling pathway
                                                        is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway [GO:0007186] (2100 genes, 2743 annotations)
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway +
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway [GO:0007186] (2100 genes, 2743 annotations)
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway +
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway [GO:0007186] (2100 genes, 2743 annotations)
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway +
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-acell surface receptor signaling pathway
                                                is-aanti-Mullerian hormone signaling pathway +
                                                is-aapolipoprotein A-I-mediated signaling pathway
                                                is-aCD40 signaling pathway +
                                                is-acell surface bile acid receptor signaling pathway
                                                is-acell surface receptor signaling pathway involved in heart development +
                                                is-acollagen-activated signaling pathway +
                                                is-acytokine-mediated signaling pathway +
                                                is-aenzyme linked receptor protein signaling pathway +
                                                is-aextrinsic apoptotic signaling pathway +
                                                is-aFas signaling pathway +
                                                is-aG-protein coupled receptor signaling pathway [GO:0007186] (2100 genes, 2743 annotations)
                                                        is-aadrenergic receptor signaling pathway +
                                                        is-aangiotensin-activated signaling pathway +
                                                        is-aapelin receptor signaling pathway
                                                        is-abombesin receptor signaling pathway
                                                        is-acalcitonin family receptor signaling pathway +
                                                        is-acannabinoid signaling pathway +
                                                        is-acholecystokinin signaling pathway +
                                                        is-acomplement component C5a signaling pathway
                                                        is-adimeric G-protein coupled receptor signaling pathway +
                                                        is-adopamine receptor signaling pathway +
                                                        is-aendothelin receptor signaling pathway +
                                                        is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                        is-afollicle-stimulating hormone signaling pathway
                                                        is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                        is-aG-protein coupled glutamate receptor signaling pathway +
                                                        is-aG-protein coupled purinergic receptor signaling pathway +
                                                        is-aG-protein coupled receptor signaling in absence of ligand
                                                        is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                        is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                        is-agamma-aminobutyric acid signaling pathway
                                                        is-agastric inhibitory peptide signaling pathway
                                                        part-ofheterotrimeric G-protein complex cycle
                                                        is-aluteinizing hormone signaling pathway +
                                                        negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aneuropeptide signaling pathway
                                                        is-aoctopamine or tyramine signaling pathway +
                                                        is-aopioid receptor signaling pathway +
                                                        is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                        is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                        is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                        is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                        positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                        is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                        regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                        is-arhodopsin mediated signaling pathway +
                                                        is-aserotonin receptor signaling pathway +
                                                        is-asignal transduction involved in conjugation with mutual genetic exchange
                                                        is-asomatostatin receptor signaling pathway +
                                                        is-asphingosine-1-phosphate signaling pathway +
                                                        is-atachykinin receptor signaling pathway +
                                                        is-athrombin receptor signaling pathway +
                                                        is-athromboxane A2 signaling pathway
                                                        is-athyroid-stimulating hormone signaling pathway
                                                is-aglutamate receptor signaling pathway +
                                                is-aimmune response-regulating cell surface receptor signaling pathway +
                                                is-aintegrin-mediated signaling pathway +
                                                is-alipopolysaccharide-mediated signaling pathway +
                                                is-anetrin-activated signaling pathway +
                                                is-aneuropilin signaling pathway +
                                                is-aneurotrophin signaling pathway +
                                                is-aNotch signaling pathway +
                                                is-apeptidoglycan recognition protein signaling pathway +
                                                is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                is-apurinergic receptor signaling pathway +
                                                is-areelin-mediated signaling pathway
                                                is-aRoundabout signaling pathway +
                                                is-asemaphorin-plexin signaling pathway +
                                                is-asmoothened signaling pathway +
                                                is-aToll signaling pathway +
                                                is-aurokinase plasminogen activator signaling pathway
                                                is-aWnt signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-acell surface receptor signaling pathway
                                                        is-aanti-Mullerian hormone signaling pathway +
                                                        is-aapolipoprotein A-I-mediated signaling pathway
                                                        is-aCD40 signaling pathway +
                                                        is-acell surface bile acid receptor signaling pathway
                                                        is-acell surface receptor signaling pathway involved in heart development +
                                                        is-acollagen-activated signaling pathway +
                                                        is-acytokine-mediated signaling pathway +
                                                        is-aenzyme linked receptor protein signaling pathway +
                                                        is-aextrinsic apoptotic signaling pathway +
                                                        is-aFas signaling pathway +
                                                        is-aG-protein coupled receptor signaling pathway [GO:0007186] (2100 genes, 2743 annotations)
                                                                is-aadrenergic receptor signaling pathway +
                                                                is-aangiotensin-activated signaling pathway +
                                                                is-aapelin receptor signaling pathway
                                                                is-abombesin receptor signaling pathway
                                                                is-acalcitonin family receptor signaling pathway +
                                                                is-acannabinoid signaling pathway +
                                                                is-acholecystokinin signaling pathway +
                                                                is-acomplement component C5a signaling pathway
                                                                is-adimeric G-protein coupled receptor signaling pathway +
                                                                is-adopamine receptor signaling pathway +
                                                                is-aendothelin receptor signaling pathway +
                                                                is-aepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
                                                                is-afollicle-stimulating hormone signaling pathway
                                                                is-aG-protein coupled acetylcholine receptor signaling pathway +
                                                                is-aG-protein coupled glutamate receptor signaling pathway +
                                                                is-aG-protein coupled purinergic receptor signaling pathway +
                                                                is-aG-protein coupled receptor signaling in absence of ligand
                                                                is-aG-protein coupled receptor signaling pathway involved in heart process +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +
                                                                is-aG-protein coupled receptor signaling pathway, coupled to S1P second messenger
                                                                is-agamma-aminobutyric acid signaling pathway
                                                                is-agastric inhibitory peptide signaling pathway
                                                                part-ofheterotrimeric G-protein complex cycle
                                                                is-aluteinizing hormone signaling pathway +
                                                                negatively-regulatesnegative regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aneuropeptide signaling pathway
                                                                is-aoctopamine or tyramine signaling pathway +
                                                                is-aopioid receptor signaling pathway +
                                                                is-apheromone-dependent signal transduction involved in conjugation with cellular fusion +
                                                                is-aphospholipase C-activating G-protein coupled receptor signaling pathway +
                                                                is-aphospholipase C-inhibiting G-protein coupled receptor signaling pathway
                                                                is-aphospholipase D-activating G-protein coupled receptor signaling pathway
                                                                positively-regulatespositive regulation of G-protein coupled receptor protein signaling pathway +
                                                                is-aprotein kinase C-activating G-protein coupled receptor signaling pathway
                                                                regulatesregulation of G-protein coupled receptor protein signaling pathway +
                                                                is-arhodopsin mediated signaling pathway +
                                                                is-aserotonin receptor signaling pathway +
                                                                is-asignal transduction involved in conjugation with mutual genetic exchange
                                                                is-asomatostatin receptor signaling pathway +
                                                                is-asphingosine-1-phosphate signaling pathway +
                                                                is-atachykinin receptor signaling pathway +
                                                                is-athrombin receptor signaling pathway +
                                                                is-athromboxane A2 signaling pathway
                                                                is-athyroid-stimulating hormone signaling pathway
                                                        is-aglutamate receptor signaling pathway +
                                                        is-aimmune response-regulating cell surface receptor signaling pathway +
                                                        is-aintegrin-mediated signaling pathway +
                                                        is-alipopolysaccharide-mediated signaling pathway +
                                                        is-anetrin-activated signaling pathway +
                                                        is-aneuropilin signaling pathway +
                                                        is-aneurotrophin signaling pathway +
                                                        is-aNotch signaling pathway +
                                                        is-apeptidoglycan recognition protein signaling pathway +
                                                        is-apositive regulation of integrin activation by cell surface receptor linked signal transduction
                                                        is-apurinergic receptor signaling pathway +
                                                        is-areelin-mediated signaling pathway
                                                        is-aRoundabout signaling pathway +
                                                        is-asemaphorin-plexin signaling pathway +
                                                        is-asmoothened signaling pathway +
                                                        is-aToll signaling pathway +
                                                        is-aurokinase plasminogen activator signaling pathway
                                                        is-aWnt signaling pathway +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory