| GO term: | G-protein coupled receptor signaling pathway |
| Synonym: | GPCR signaling pathway |
| Synonym: | GPCR signalling pathway |
| Synonym: | G protein coupled receptor protein signaling pathway |
| Synonym: | G-protein coupled receptor protein signaling pathway |
| Synonym: | G-protein-coupled receptor protein signaling pathway |
| Synonym: | G protein coupled receptor protein signalling pathway |
| Synonym: | G-protein-coupled receptor protein signalling pathway |
| Synonym: | G-protein coupled receptor protein signal transduction |
| Synonym: | G-protein coupled receptor signalling pathway |
| GO id: | GO:0007186 |
| Definition: | A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. |
| Number of paths to term: | 10 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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