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Ins2
Gene Detail
 Symbol
Name
ID
Ins2
insulin II
MGI:96573
Synonyms Ins-2, InsII, Mody, Mody4
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(36)
Sequence Map
Chr7:142678656-142699510 bp, - strand
From VEGA annotation of GRCm38

  20855 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:173  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: insulin
Gene Tree: Ins2

Human
homologs
Human Homolog INS, insulin
NCBI Gene ID 3630
neXtProt AC  NX_P01308
Human Synonyms  IDDM1, IDDM2, ILPR, IRDN, MODY10
Human Chr (Location)  11p15.5; chr11:2159779-2161209 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human INS
Alleles
and
phenotypes
All alleles(123) : Targeted(15) Gene trapped(106) Spontaneous(1) Chemically induced(1)
 
Mice homozygous for spontaneous or knock-out alleles exhibit increased mortality, abnormal growth, abnormal glucose homeostasis, impaired pancreatic function, and phenotypes associated with type 2 diabetes.
 
Human Diseases Modeled Using Mouse Ins2 (4)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process activation of MAPK activity, activation of protein kinase B activity, ...
Component cytoplasm, extracellular region, ...
Function hormone activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (313 records)
Data Summary: Results (300)    Tissues (115)    Images (105)
Theiler Stages: 2, 3, 5, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 89
RNA in situ 21
RT-PCR 190
cDNA source data(142)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(195) Genomic(30) cDNA(143) Primer pair(19) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018794 (Evidence)
Ensembl Gene ModelENSMUSG00000000215 (Evidence)
Entrez Gene16334 (Evidence)
UniGene4946
DFCITC1573941, TC1594024, TC1652536
DoTSDT.101400113, DT.101400114, DT.103585207, DT.103585231, DT.94397640, DT.94397663
NIA Mouse Gene IndexU029487
Consensus CDS ProjectCCDS22034.1
International Mouse Knockout Project StatusIns2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018794 VEGA Gene Model | MGI Sequence Detail 20855 C57BL/6J ±  kb
transcript OTTMUST00000045252 VEGA | MGI Sequence Detail 480 Not Applicable 
polypeptide OTTMUSP00000020356 VEGA | MGI Sequence Detail 110 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(6) UniProt(7)
Polymorphisms All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004825 Insulin
InterPro IPR022353 Insulin, conserved site
InterPro IPR022352 Insulin family
InterPro IPR016179 Insulin-like
Protein Ontology PR:000009190 insulin-2
References (Earliest) J:6658 Goldfeld AE, et al., Genetic control of insulin receptors. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6359-61
(Latest) J:206472 Winnay JN, et al., p85alpha deficiency protects beta-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1192-7
All references(571)
Other
accession IDs
MGD-MRK-11411, MGD-MRK-11414, MGD-MRK-39550, MGI:109551, MGI:2141856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory