Ins2
Gene Detail

Symbol Name ID

Ins2 insulin II MGI:96573

Synonyms

Ins-2, InsII, Mody, Mody4

Feature Type

protein coding gene

Genetic Map

Chromosome 7

88.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(36)

Sequence Map

Chr7:142678656-142699510 bp, - strand From VEGA annotation of GRCm38   20855 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:173  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: insulin
Gene Tree: Ins2

Human homologs

Human Homolog		INS, insulin
NCBI Gene ID		3630
neXtProt AC		NX_P01308
Human Synonyms		IDDM2, ILPR, IRDN, MODY10
Human Chr (Location)		11p15.5; chr11:2181009-2182439 (-)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human INS

Alleles and phenotypes

All alleles(122) : Targeted(14) Gene trapped(106) Spontaneous(1) Chemically induced(1)
 

Mice homozygous for spontaneous or knock-out alleles exhibit increased mortality, abnormal growth, abnormal glucose homeostasis, impaired pancreatic function, and phenotypes associated with type 2 diabetes.

 
Human Diseases Modeled Using Mouse Ins2 (3)    Alleles Annotated to Human Diseases(2)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (73 annotations)

Process	activation of MAPK activity, activation of protein kinase B activity, ...
Component	cytoplasm, extracellular region, ...
Function	hormone activity, insulin-like growth factor receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (294 records)
Data Summary: Results (292)    Tissues (116)    Images (97)
Theiler Stages: 2, 3, 5, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	81
RNA in situ	21
RT-PCR	190

cDNA source data(142)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(195) Genomic(30) cDNA(143) Primer pair(19) Other(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000018794 (Evidence)
Ensembl Gene Model	ENSMUSG00000000215 (Evidence)
Entrez Gene	16334 (Evidence)
UniGene	4946
DFCI	TC1573941, TC1594024, TC1652536
DoTS	DT.101400113, DT.101400114, DT.103585207, DT.103585231, DT.94397640, DT.94397663
NIA Mouse Gene Index	U029487
Consensus CDS Project	CCDS22034.1
International Mouse Knockout Project Status	Ins2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018794	VEGA Gene Model | MGI Sequence Detail	20855	C57BL/6J
transcript	OTTMUST00000045252	VEGA | MGI Sequence Detail	480	Not Applicable
polypeptide	OTTMUSP00000020356	VEGA | MGI Sequence Detail	110	Not Applicable

All sequences(71) RefSeq(6) UniProt(7)

Polymorphisms

All PCR and RFLP(6) : PCR(3) RFLP(3) SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004825	Insulin
InterPro	IPR022353	Insulin, conserved site
InterPro	IPR022352	Insulin family
InterPro	IPR016179	Insulin-like
Protein Ontology	PR:000009190	insulin-2

References

(Earliest) J:6658 Goldfeld AE, et al., Genetic control of insulin receptors. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6359-61
(Latest) J:193959 Georgia S, et al., DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis. Genes Dev. 2013 Feb 15;27(4):372-7
All references(526)

Other accession IDs

MGD-MRK-11411, MGD-MRK-11414, MGD-MRK-39550, MGI:109551, MGI:2141856