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Ins2 Gene Detail
Summary
  • Symbol
    Ins2
  • Name
    insulin II
  • Synonyms
    Ins-2, InsII, Mody, Mody4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96573
    NCBI Gene: 16334
  • Gene Overview
    MyGene.info: INS
Location & Maps
more
  • Sequence Map
    Chr7:142678656-142743381 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64726 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.00 cM
  • Mapping Data
    34 experiments
Homology
more
  • Human Ortholog
    INS, insulin
  • Vertebrate Orthologs
    8
  • Human Ortholog
    INS, insulin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10
  • Links
    NCBI Gene ID: 3630
    neXtProt AC: NX_P01308

  • Chr Location
    11p15.5; chr11:2159779-2161209 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with Ins2 mouse models; 4 with human INS associations

Human Disease Mouse Models
       Diabetes Mellitus, Permanent Neonatal; PNDM   OMIM: 606176 View 1 model
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 7 models
Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Maturity-Onset Diabetes of the Young; MODY   OMIM: 606391 View 3 models
       Diabetes Mellitus, Insulin-Dependent, 2   OMIM: 125852
Hyperproinsulinemia   OMIM: 616214
Maturity-Onset Diabetes of the Young, Type 10; MODY10   OMIM: 613370
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    31 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    95 phenotypes from 8 alleles in 12 genetic backgrounds
    77 phenotypes from multigenic genotypes
    4 images
    236 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    131
  • Chemically induced (ENU)
    1
  • Gene trapped
    106
  • Spontaneous
    1
  • Targeted
    16
  • Transgenic
    7
Mice homozygous for spontaneous or knock-out alleles exhibit increased mortality, abnormal growth, abnormal glucose homeostasis, impaired pancreatic function, and phenotypes associated with type 2 diabetes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018794 VEGA Gene Model | MGI Sequence Detail 64726 C57BL/6J ±  kb
transcript OTTMUST00000045252 VEGA | MGI Sequence Detail 480 Not Applicable  
polypeptide OTTMUSP00000020356 VEGA | MGI Sequence Detail 110 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    342 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 197
    Genomic 30
    cDNA 143
    Primer pair 20
    Other 4

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11411, MGD-MRK-11414, MGD-MRK-39550, MGI:109551, MGI:2141856
References
more
  • Summaries
    All 670
    Developmental Gene Expression 361
    Diseases 31
    Gene Ontology 19
    Phenotypes 236
  • Earliest
    J:6658 Goldfeld AE, et al., Genetic control of insulin receptors. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6359-61
  • Latest
    J:233842 Neumann UH, et al., Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy. Endocrinology. 2016 Mar;157(3):1007-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory