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Phenotypes Associated with This Genotype
Genotype
MGI:3619380
Allelic
Composition		 Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)1Ell/0
Genetic
Background		 NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (5 available); any Ins1 mutation (44 available)
Ins2tm1Jja mutation (4 available); any Ins2 mutation (93 available)
Tg(Ins2*Y16A)1Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:98583 )
• male transgenic mice lacking both native insulin genes develop diabetes before 10 weeks of age (2 consecutive measurements of >250 mg/dl glucose)

immune system
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis
decreased susceptibility to autoimmune diabetes ( J:98583 )
• female transgenic mice lacking both native insulin genes do not exhibit diabetes by 30 weeks of age

endocrine/exocrine glands
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis

digestive/alimentary system
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:98583

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory