Phenotypes Associated with This Genotype

Genotype
MGI:3583906

• Allelic Composition: Ins2^Akita/Ins2^Akita
• Genetic Background: C57BL/6-Ins2^Akita

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:47883 )

homeostasis/metabolism

decreased insulin secretion ( J:47883 )

• the pancreatic ratio of insulin to glucagon is decreased to 0.21 and 0.01 at birth and 14 days of age, respectively, compared to 1.17 and 1.11 in wild-type mice

hyperglycemia ( J:47883 )

• blood glucose levels are slightly higher at 1 day of age and much higher at 14 days of age with no gender differences seen

endocrine/exocrine glands

abnormal pancreatic alpha cell morphology ( J:47883 )

• alpha cell density is markedly increased

abnormal pancreatic beta cell morphology ( J:47883 )

• density of beta cells is decreased within 24 hours of birth and at 2 weeks of age

• beta cell granules are fewer in number and smaller and mitochondrial swelling and an increase in endoplasmic reticulum are seen at 2 weeks of age

small pancreatic islets ( J:47883 )

• islet area is reduced

decreased insulin secretion ( J:47883 )

• the pancreatic ratio of insulin to glucagon is decreased to 0.21 and 0.01 at birth and 14 days of age, respectively, compared to 1.17 and 1.11 in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
permanent neonatal diabetes mellitus		DOID:0060639	OMIM:606176	J:47883