Phenotypes Associated with This Genotype

Genotype
MGI:5508894

• Allelic Composition: Ins2^Akita/Ins2^Akita
• Genetic Background: C.B6N-Ins2^Akita

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:198186 )

• approximately 20% of mutants fail to thrive and are sacrificed at 6 months of age

cardiovascular system

abnormal glomerular capillary morphology ( J:198186 )

• mice show a decrease in CD31 positive structures in the glomeruli, indicating collapse of the glomerular tufts

growth/size/body

decreased body weight ( J:198186 )

• reduced body weight at 4 and 6 months of age

homeostasis/metabolism

hyperglycemia ( J:198186 )

albuminuria ( J:198186 )

• 3-fold increase in albumin-to-creatine ratio at 4 months of age; albuminuria persists in mutants at 6 months of age

renal/urinary system

abnormal glomerular capillary morphology ( J:198186 )

• mice show a decrease in CD31 positive structures in the glomeruli, indicating collapse of the glomerular tufts

albuminuria ( J:198186 )

• 3-fold increase in albumin-to-creatine ratio at 4 months of age; albuminuria persists in mutants at 6 months of age

increased renal glomerulus basement membrane thickness ( J:198186 )

expanded mesangial matrix ( J:198186 )

• mesangial matrix expansion is seen at 4 months of age and is more pronounced than in heterozygous mice

glomerulosclerosis ( J:198186 )

• same degree of glomerular injury as in heterozygotes at 6 months of age

renal glomerular protein deposits ( J:198186 )

• increase in glomerular collagen IV deposition at 6 months of age

abnormal kidney interstitium morphology ( J:198186 )

• small increase in collagen I in the tubulointerstitial compartment of the kidney

• however, tubulointerstitial fibrosis is not observed

increased renal glomerular filtration rate ( J:198186 )

• glomerular filtration rate is increased at 4 months of age but decreased by 6 months of age to normal levels

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:198186