About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3619054
Allelic
Composition		 Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)3Ell/0
Genetic
Background		 NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)3Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (5 available); any Ins1 mutation (46 available)
Ins2tm1Jja mutation (4 available); any Ins2 mutation (93 available)
Tg(Ins2*Y16A)3Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis
decreased susceptibility to autoimmune diabetes ( J:98583 )
• no female double knockout mice carrying the transgene on a NOD background develop diabetes over 30 weeks of observation
decreased anti-insulin autoantibody level ( J:98583 )
• females lacking both insulin genes do not produce insulin autoantibodies

digestive/alimentary system
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis

endocrine/exocrine glands
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:98583

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory