91 phenotypes from 8 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ins2Akita/Ins2+ C57BL/6-Ins2Akita	abnormal Leydig cell morphology	J:108948
	abnormal mitochondrial morphology	J:108948
	abnormal pancreatic beta cell morphology	J:47883
	akinesia	J:125256
	decreased body weight	J:125256
	decreased bone mineral density	J:108948
	decreased circulating insulin level	J:40063
	decreased insulin secretion	J:40063, J:47883
	decreased locomotor activity	J:125256
	decreased subcutaneous adipose tissue amount	J:108948
	degranulated pancreatic beta cells	J:47883
	hydronephrosis	J:40063
	hyperglycemia	J:40063, J:125256
	impaired glucose tolerance	J:40063
	increased anxiety-related response	J:125256
	increased fluid intake	J:125256
	kyphosis	J:108948
	polydipsia	J:40063
	polyphagia	J:125256
	polyuria	J:40063
	postnatal growth retardation	J:40063
	premature death	J:40063, J:108948
Ins2Akita/Ins2+ C57BL/6-Ins2Akita/J	abnormal astrocyte morphology	J:99412
	abnormal microglial cell morphology	J:99412
	abnormal response to transplant	J:76224
	abnormal retina ganglion layer morphology	J:99412
	abnormal retina neuronal layer morphology	J:99412
	abnormal retina vasculature morphology	J:99412
	decreased body weight	J:99412
	hyperglycemia	J:76224, J:99412
	increased insulin sensitivity	J:76224
	increased leukocyte cell number	J:99412
	increased retina apoptosis	J:99412
	increased vascular permeability	J:99412
Ins2Akita/Ins2+ C.B6N-Ins2Akita	albuminuria	J:198186
	expanded mesangial matrix	J:198186
	glomerulosclerosis	J:198186
	increased renal glomerular filtration rate	J:198186
Ins2Akita/Ins2+ involves: C3H * C57BL/6NJcl * C57BL/6NSlc	hyperglycemia	J:40063
	impaired glucose tolerance	J:40063
Ins2Akita/? involves: C57BL/6NSlc	abnormal cardiac muscle contractility	J:130021
	abnormal glucose homeostasis	J:130021
	abnormal heart left ventricle morphology	J:130021
	abnormal heart morphology	J:130021
	decreased adipocyte glucose uptake	J:130021
	decreased body fat mass	J:130021
	decreased body weight	J:130021
	decreased circulating insulin level	J:130021
	decreased circulating triglyceride level	J:130021
	decreased liver triglyceride level	J:130021
	decreased locomotor activity	J:130021
	decreased muscle cell glucose uptake	J:130021
	decreased respiratory quotient	J:130021
	decreased skeletal muscle triglyceride level	J:130021
	heart left ventricle hypertrophy	J:130021
	hyperglycemia	J:130021
	increased adipocyte glucose uptake	J:130021
	increased carbon dioxide production	J:130021
	increased energy expenditure	J:130021
	increased food intake	J:130021
	increased oxygen consumption	J:130021
	insulin resistance	J:130021
	thick interventricular septum	J:130021
Ins2Akita/Ins2+ involves: C57BL/6NSlc	abnormal pancreatic islet morphology	J:200802
	decreased body weight	J:200802
	decreased circulating leptin level	J:200802
	decreased insulin secretion	J:200802
	normal homeostasis/metabolism phenotype	J:200802
	increased circulating glucose level	J:200802
	increased food intake	J:200802
Ins2Akita/Ins2Akita C57BL/6-Ins2Akita	abnormal pancreatic alpha cell morphology	J:47883
	abnormal pancreatic beta cell morphology	J:47883
	decreased insulin secretion	J:47883
	hyperglycemia	J:47883
	postnatal lethality	J:47883
	small pancreatic islets	J:47883
Ins2Akita/Ins2Akita C57BL/6-Ins2Akita/J	hyperglycemia	J:76224
	premature death	J:76224
Ins2Akita/Ins2Akita C.B6N-Ins2Akita	abnormal glomerular capillary morphology	J:198186
	abnormal kidney interstitium morphology	J:198186
	albuminuria	J:198186
	decreased body weight	J:198186
	expanded mesangial matrix	J:198186
	glomerulosclerosis	J:198186
	hyperglycemia	J:198186
	increased renal glomerular filtration rate	J:198186
	increased renal glomerulus basement membrane thickness	J:198186
	premature death	J:198186
	renal glomerular protein deposits	J:198186
Ins2Akita/Ins2Akita involves: C57BL/6NSlc	abnormal pancreas physiology	J:156725
	decreased circulating insulin level	J:156725
	decreased insulin secretion	J:156725
	decreased pancreatic beta cell mass	J:156725
	hematoma	J:168556
	hyperglycemia	J:156725
	increased pancreatic islet cell apoptosis	J:156725
Ins2C95S/Ins2+ C3HeB/FeJ-Ins2C95S	abnormal pancreatic beta cell morphology	J:122098
	abnormal pancreatic beta cell physiology	J:122098
	abnormal pancreatic islet morphology	J:122098
	decreased body weight	J:122098
	decreased circulating insulin level	J:122098
	decreased insulin secretion	J:122098
	decreased pancreatic beta cell number	J:122098
	disorganized pancreatic islets	J:122098
	hyperglycemia	J:122098, J:137483
	increased circulating glucose level	J:122098
	increased pancreatic alpha cell number	J:122098
	increased susceptibility to autoimmune diabetes	J:122098
	increased urine glucose level	J:122098
	insulin resistance	J:122098
Ins2C95S/Ins2C95S C3HeB/FeJ-Ins2C95S	decreased body weight	J:122098
	increased circulating glucose level	J:122098
	increased susceptibility to autoimmune diabetes	J:122098
	increased urine glucose level	J:122098
	premature death	J:122098
Ins2em#Arak/Ins2+ C.129-Rag2tm1Fwa Ins2em#Arak Jak3tm1Tks/Arak	abnormal homeostasis	J:294041
	abnormal pancreatic beta cell morphology	J:294041
	abnormal pancreatic islet morphology	J:294041
	hyperglycemia	J:294041
	impaired glucose tolerance	J:294041
	polyuria	J:294041
	small pancreatic islets	J:294041
Ins2tm1(cre/ERT2)Kcmm/Ins2tm1(cre/ERT2)Kcmm Not Specified	normal homeostasis/metabolism phenotype	J:171567
Ins2tm1Jja/Ins2tm1Jja involves: 129S2/SvPas	increased insulin secretion	J:77595
	increased pancreatic beta cell mass	J:77595
	increased pancreatic beta cell number	J:77595
Ins2tm1Jja/Ins2tm1Jja NOD.129S2-Ins2tm1Jja	abnormal glucose homeostasis	J:85309
	increased anti-insulin autoantibody level	J:85309
	insulitis	J:85309
Ins2tm1Nagy/Ins2tm1Nagy involves: 129S1/Sv * 129X1/SvJ * Hsd:ICR	no abnormal phenotype detected	J:153719
Ins2tm1Rll/Ins2tm1Rll Not Specified	normal homeostasis/metabolism phenotype	J:196410
Tg(H2-Ea-Ins2)1Wehi/0 NOD/ShiLtJWehi-Tg(H2-Ea-Ins2)1Wehi	abnormal T cell proliferation	J:100232
	normal endocrine/exocrine gland phenotype	J:100232
	normal immune system phenotype	J:100232
	salivary gland inflammation	J:100232
Tg(H2-Ea-Ins2)1Wehi/Tg(H2-Ea-Ins2)1Wehi NOD/ShiLtJWehi-Tg(H2-Ea-Ins2)1Wehi	abnormal CD8-positive, alpha beta T cell morphology	J:117352
	decreased anti-insulin autoantibody level	J:117352
	decreased T cell proliferation	J:117352
	normal hematopoietic system phenotype	J:117352
	normal immune system phenotype	J:117352