Phenotypes Associated with This Genotype

Genotype
MGI:3716137

• Allelic Composition: Ins2^tm1Jja/Ins2^tm1Jja
• Genetic Background: NOD.129S2-Ins2^tm1Jja

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Severe insulitis in Ins2^tm1Jja/Ins2^tm1Jja mice and lack of insulitis in Ins1^tm1Jja/Ins1^tm1Jja mice

homeostasis/metabolism

abnormal glucose homeostasis ( J:85309 )

• development of diabetes is accelerated compared to wild-type controls; all but one female develop diabetes between 7 and 15 weeks of age

immune system

insulitis ( J:85309 )

• severe insulitis with primarily intraislet infiltrates

increased anti-insulin autoantibody level ( J:85309 )

• both males and females have higher peak levels of insulin autoantibodies than wild-type

endocrine/exocrine glands

insulitis ( J:85309 )

• severe insulitis with primarily intraislet infiltrates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:85309