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Gene Ontology Browser
Term Detail
GO term:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Synonym: apoptosis in response to endoplasmic reticulum stress
Synonym: apoptosis in response to ER stress
Synonym: apoptosis triggered by ER stress
Synonym: endoplasmic reticulum stress-induced apoptosis
Synonym: ER stress-induced apoptosis
Synonym: intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress
GO id:GO:0070059
Definition:A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Number of paths to term: 24

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aapoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-aintrinsic apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response +
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                        regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                part-ofnegative regulation of translation involved in response to endoplasmic reticulum stress
                                                is-aregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-aintrinsic apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway
                                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response +
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                        regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                part-ofnegative regulation of translation involved in response to endoplasmic reticulum stress
                                                is-aregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response +
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                        regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                part-ofnegative regulation of translation involved in response to endoplasmic reticulum stress
                                                is-aregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-adeath
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway
                                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aapoptotic signaling pathway
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-aintrinsic apoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aapoptotic signaling pathway
                                                        is-aintrinsic apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-aintrinsic apoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                                is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                regulatesregulation of intrinsic apoptotic signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell death
                                        is-aprogrammed cell death
                                                is-aapoptotic process
                                                        part-ofapoptotic signaling pathway
                                                                is-aintrinsic apoptotic signaling pathway
                                                                        is-aintrinsic apoptotic signaling pathway by p53 class mediator +
                                                                        is-aintrinsic apoptotic signaling pathway in response to DNA damage +
                                                                        is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (32 genes, 39 annotations)
                                                                                negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                                positively-regulatespositive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                                                                regulatesregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to hypoxia
                                                                        is-aintrinsic apoptotic signaling pathway in response to osmotic stress +
                                                                        is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                                        negatively-regulatesnegative regulation of intrinsic apoptotic signaling pathway +
                                                                        positively-regulatespositive regulation of intrinsic apoptotic signaling pathway +
                                                                        regulatesregulation of intrinsic apoptotic signaling pathway +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory