| GO term: | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| Synonym: | apoptosis in response to endoplasmic reticulum stress |
| Synonym: | apoptosis in response to ER stress |
| Synonym: | apoptosis triggered by ER stress |
| Synonym: | endoplasmic reticulum stress-induced apoptosis |
| Synonym: | ER stress-induced apoptosis |
| Synonym: | intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress |
| GO id: | GO:0070059 |
| Definition: | A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
| Number of paths to term: | 44 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processregulation of cellular processregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processregulation of cellular processsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcell deathprogrammed cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to endoplasmic reticulum stressendoplasmic reticulum unfolded protein response +ER overload response +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)negative regulation of translation involved in response to endoplasmic reticulum stressregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stressbiological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processcellular processsingle-organism cellular processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processregulation of biological processregulation of cellular processregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processregulation of biological processregulation of cellular processsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processresponse to stimuluscellular response to stimuluscellular response to stressresponse to endoplasmic reticulum stressendoplasmic reticulum unfolded protein response +ER overload response +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)negative regulation of translation involved in response to endoplasmic reticulum stressregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stressbiological_processresponse to stimuluscellular response to stimulussignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processresponse to stimulusresponse to stresscellular response to stressresponse to endoplasmic reticulum stressendoplasmic reticulum unfolded protein response +ER overload response +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)negative regulation of translation involved in response to endoplasmic reticulum stressregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stressbiological_processsignalingsingle organism signalingsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsignalingsingle organism signalingsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processdeathcell deathprogrammed cell deathapoptotic processregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processdeathcell deathprogrammed cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processdeathcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle organism signalingsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathapoptotic processregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell deathprogrammed cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcell deathregulation of cell deathregulation of programmed cell deathregulation of apoptotic processregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to stressresponse to endoplasmic reticulum stressendoplasmic reticulum unfolded protein response +ER overload response +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)negative regulation of translation involved in response to endoplasmic reticulum stressregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stressbiological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +biological_processsingle-organism processsingle-organism cellular processexecution phase of apoptosisregulation of execution phase of apoptosisapoptotic signaling pathwayintrinsic apoptotic signaling pathwayintrinsic apoptotic signaling pathway by p53 class mediator +intrinsic apoptotic signaling pathway in response to DNA damage +intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059] (20 genes, 23 annotations)intrinsic apoptotic signaling pathway in response to osmotic stressintrinsic apoptotic signaling pathway in response to oxidative stressnegative regulation of intrinsic apoptotic signaling pathwaypositive regulation of intrinsic apoptotic signaling pathwayregulation of intrinsic apoptotic signaling pathway +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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