About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:ER overload response
Synonym: endoplasmic reticulum overload response
Synonym: EOR
Synonym: ER-overload response
GO id:GO:0006983
Definition:The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.
Number of paths to term: 15

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aER-nucleus signaling pathway
                                                        is-aendoplasmic reticulum unfolded protein response +
                                                        is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                                is-aautophagy in response to ER overload
                                                                is-adetection of endoplasmic reticulum overloading
                                                                is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                        is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to biotic stimulus
                                        is-acellular response to external biotic stimulus
                                        is-acellular response to molecule of bacterial origin +
                                        is-acellular response to molecule of fungal origin
                                        is-acellular response to molecule of oomycetes origin
                                        is-acellular response to tumor cell
                                        is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                is-aautophagy in response to ER overload
                                                is-adetection of endoplasmic reticulum overloading
                                                is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                        is-aresponse to cell cycle checkpoint signaling +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                        is-aautophagy in response to ER overload
                                                        is-adetection of endoplasmic reticulum overloading
                                                        is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                is-anegative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                part-ofnegative regulation of translation involved in response to endoplasmic reticulum stress
                                                is-apositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                is-aregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                        is-aautophagy in response to ER overload
                                                        is-adetection of endoplasmic reticulum overloading
                                                        is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                        is-aautophagy in response to ER overload
                                                        is-adetection of endoplasmic reticulum overloading
                                                        is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aER-nucleus signaling pathway
                                                        is-aendoplasmic reticulum unfolded protein response +
                                                        is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                                is-aautophagy in response to ER overload
                                                                is-adetection of endoplasmic reticulum overloading
                                                                is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                        is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                        is-aautophagy in response to ER overload
                                                        is-adetection of endoplasmic reticulum overloading
                                                        is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to biotic stimulus
                                        is-acellular response to external biotic stimulus
                                        is-acellular response to molecule of bacterial origin +
                                        is-acellular response to molecule of fungal origin
                                        is-acellular response to molecule of oomycetes origin
                                        is-acellular response to tumor cell
                                        is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                is-aautophagy in response to ER overload
                                                is-adetection of endoplasmic reticulum overloading
                                                is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                        is-aresponse to cell cycle checkpoint signaling +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                        is-aautophagy in response to ER overload
                                                        is-adetection of endoplasmic reticulum overloading
                                                        is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                is-anegative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                part-ofnegative regulation of translation involved in response to endoplasmic reticulum stress
                                                is-apositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                is-aregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                        is-aautophagy in response to ER overload
                                                        is-adetection of endoplasmic reticulum overloading
                                                        is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to biotic stimulus
                                is-acellular response to biotic stimulus
                                        is-acellular response to external biotic stimulus
                                        is-acellular response to molecule of bacterial origin +
                                        is-acellular response to molecule of fungal origin
                                        is-acellular response to molecule of oomycetes origin
                                        is-acellular response to tumor cell
                                        is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                is-aautophagy in response to ER overload
                                                is-adetection of endoplasmic reticulum overloading
                                                is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                        is-aresponse to cell cycle checkpoint signaling +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress
                                        is-aresponse to endoplasmic reticulum stress
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                        is-aautophagy in response to ER overload
                                                        is-adetection of endoplasmic reticulum overloading
                                                        is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                is-aintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +
                                                is-anegative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                part-ofnegative regulation of translation involved in response to endoplasmic reticulum stress
                                                is-apositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
                                                is-aregulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                        is-aautophagy in response to ER overload
                                                        is-adetection of endoplasmic reticulum overloading
                                                        is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aER-nucleus signaling pathway
                                                is-aendoplasmic reticulum unfolded protein response +
                                                is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                        is-aautophagy in response to ER overload
                                                        is-adetection of endoplasmic reticulum overloading
                                                        is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                is-aSREBP signaling pathway +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aER-nucleus signaling pathway
                                                        is-aendoplasmic reticulum unfolded protein response +
                                                        is-aER overload response [GO:0006983] (10 genes, 13 annotations)
                                                                is-aautophagy in response to ER overload
                                                                is-adetection of endoplasmic reticulum overloading
                                                                is-apositive regulation of NF-kappaB transcription factor activity by ER overload response
                                                        is-aSREBP signaling pathway +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory