Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Adora2a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ADORA2A
- Mouse genes Adora2a
- Rat genes Adora2a
- Zfish genes adora2aa,adora2ab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Adora2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051393	alpha-actinin binding	Adora2a	IDA		Rat	PMID:12837758\|RGD:1304399
Molecular Function	GO:0019899	enzyme binding	ADORA2A	IPI	UniProtKB:Q13107	Human	PMID:16339847
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	ADORA2A	IDA		Human	PMID:21393508
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	ADORA2A	IDA		Human	PMID:21593763
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora2a	IMP	MGI:MGI:2155985	Mouse	PMID:11172060
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora2a	IMP	MGI:MGI:2155985	Mouse	PMID:10845921
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora2a	IDA		Mouse	PMID:8738226
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora2a	IDA		Mouse	PMID:10908627
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora2a	IDA		Mouse	PMID:10934242
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora2a	IDA		Mouse	PMID:12223546
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	Adora2a	IDA		Rat	PMID:12590138\|RGD:1625697
Molecular Function	GO:0042802	identical protein binding	ADORA2A	IPI	UniProtKB:P29274	Human	PMID:18675812
Molecular Function	GO:0042802	identical protein binding	ADORA2A	IPI	UniProtKB:P29274	Human	PMID:19013155
Molecular Function	GO:0042802	identical protein binding	ADORA2A	IPI	UniProtKB:P29274	Human	PMID:29568380
Molecular Function	GO:0008289	lipid binding	ADORA2A	IPI	ChEBI:45240	Human	PMID:25692595
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:P06400	Human	PMID:11571652
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:P31424-1	Human	PMID:12189203
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:Q99418	Human	PMID:16027149
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:Q13107	Human	PMID:16339847
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:P30542	Human	PMID:16481441
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:P21554	Human	PMID:17356572
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:Q7Z6G3	Human	PMID:17689978
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:Q7Z6G3	Human	PMID:19694902
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:P21554	Human	PMID:23296780
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:P0DP23	Human	PMID:25692595
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:P21554	Human	PMID:28102227
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:O15354	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:Q5T9L3-1	Human	PMID:28734904
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:P29275	Human	PMID:29568380
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:Q5T9L3-1	Human	PMID:31286866
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:O15155	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ADORA2A	IPI	UniProtKB:O43759-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Adora2a	IPI	RGD:621574	Rat	PMID:16617164\|RGD:1625626
Molecular Function	GO:0005515	protein binding	Adora2a	IPI	UniProtKB:Q9QZE7	Rat	PMID:16617164\|RGD:1625626
Molecular Function	GO:0005515	protein binding	Adora2a	IPI	UniProtKB:P20272	Rat	PMID:17356572\|RGD:8554571
Molecular Function	GO:0005515	protein binding	Adora2a	IPI	UniProtKB:D3ZUE1	Rat	PMID:23994616\|RGD:14697711
Molecular Function	GO:0005515	protein binding	Adora2a	IPI	UniProtKB:Q5SSG4	Rat	PMID:23994616\|RGD:14697711
Molecular Function	GO:0044877	protein-containing complex binding	Adora2a	IPI	RGD:2048	Rat	PMID:16481441\|RGD:1625231
Molecular Function	GO:0031802	type 5 metabotropic glutamate receptor binding	Adora2a	IPI	RGD:2746	Rat	PMID:12189203\|RGD:625594
Cellular Component	GO:0032279	asymmetric synapse	Adora2a	IDA		Rat	PMID:16481441\|RGD:1625231
Cellular Component	GO:0030673	axolemma	Adora2a	IDA		Rat	PMID:16481441\|RGD:1625231
Cellular Component	GO:0030424	axon	Adora2a	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0030425	dendrite	Adora2a	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0012505	endomembrane system	Adora2a	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0098978	glutamatergic synapse	Adora2a	EXP		Rat	PMID:15659214\|RGD:1625642
Cellular Component	GO:0098978	glutamatergic synapse	Adora2a	IDA		Rat	PMID:15659214\|RGD:1625642
Cellular Component	GO:0005882	intermediate filament	Adora2a	IDA		Rat	PMID:16644907\|RGD:1625443
Cellular Component	GO:0016020	membrane	Adora2a	IDA		Mouse	PMID:10908627
Cellular Component	GO:0016020	membrane	Adora2a	IDA		Mouse	PMID:8738226
Cellular Component	GO:0016020	membrane	Adora2a	IDA		Rat	PMID:12189203\|RGD:625594
Cellular Component	GO:0043025	neuronal cell body	Adora2a	IDA		Rat	PMID:16644907\|RGD:1625443
Cellular Component	GO:0005886	plasma membrane	ADORA2A	IDA		Human	PMID:25644539
Cellular Component	GO:0005886	plasma membrane	ADORA2A	IDA		Human	PMID:16339847
Cellular Component	GO:0005886	plasma membrane	ADORA2A	IMP		Human	PMID:21393508
Cellular Component	GO:0005886	plasma membrane	Adora2a	IDA		Mouse	PMID:12817016
Cellular Component	GO:0005886	plasma membrane	Adora2a	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0005886	plasma membrane	Adora2a	IDA		Rat	PMID:23994616\|RGD:14697711
Cellular Component	GO:0014069	postsynaptic density	Adora2a	IDA		Rat	PMID:15659214\|RGD:1625642
Cellular Component	GO:0045211	postsynaptic membrane	Adora2a	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0045211	postsynaptic membrane	Adora2a	IDA		Rat	PMID:16481441\|RGD:1625231
Cellular Component	GO:0048786	presynaptic active zone	Adora2a	IDA		Rat	PMID:16481441\|RGD:1625231
Cellular Component	GO:0042734	presynaptic membrane	Adora2a	IDA		Rat	PMID:16952160\|RGD:1625217
Cellular Component	GO:0042734	presynaptic membrane	Adora2a	IDA		Rat	PMID:16481441\|RGD:1625231
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ADORA2A	IDA		Human	PMID:21393508
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adora2a	IDA		Mouse	PMID:9269779
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adora2a	IDA		Mouse	PMID:12223546
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adora2a	IDA		Mouse	PMID:8738226
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adora2a	IGI	MGI:MGI:99673	Mouse	PMID:12223546
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adora2a	IMP	MGI:MGI:2155985	Mouse	PMID:10845921
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adora2a	IDA		Mouse	PMID:10934242
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adora2a	IMP		Rat	PMID:16478979\|RGD:1625630
Biological Process	GO:0097190	apoptotic signaling pathway	Adora2a	IMP	MGI:MGI:2155985	Mouse	PMID:10845921
Biological Process	GO:0048143	astrocyte activation	Adora2a	IMP		Rat	PMID:12838511\|RGD:1625689
Biological Process	GO:0042755	eating behavior	Adora2a	IGI	MGI:MGI:98735	Mouse	PMID:12538862
Biological Process	GO:0042755	eating behavior	Adora2a	IMP		Rat	PMID:12827647\|RGD:1625682
Biological Process	GO:0060079	excitatory postsynaptic potential	Adora2a	IDA		Rat	PMID:16644907\|RGD:1625443
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	Adora2a	IGI	MGI:MGI:99673	Mouse	PMID:12223546
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	Adora2a	IMP	MGI:MGI:2155985	Mouse	PMID:10845921
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	Adora2a	IDA		Mouse	PMID:12223546
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	Adora2a	IDA		Rat	PMID:12590138\|RGD:1625697
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Adora2a	IMP	MGI:MGI:2152583	Mouse	PMID:11404425
Biological Process	GO:0060047	heart contraction	adora2aa	IMP	ZFIN:ZDB-MRPHLNO-130524-2	Zfish	PMID:23341106
Biological Process	GO:0060047	heart contraction	adora2aa	IMP	ZFIN:ZDB-MRPHLNO-130524-1	Zfish	PMID:23341106
Biological Process	GO:0060080	inhibitory postsynaptic potential	Adora2a	IGI	MGI:MGI:95815	Mouse	PMID:10704492
Biological Process	GO:0007626	locomotory behavior	Adora2a	IGI	MGI:MGI:94924	Mouse	PMID:10908627
Biological Process	GO:0007626	locomotory behavior	Adora2a	IGI	MGI:MGI:1351342	Mouse	PMID:16280580
Biological Process	GO:0007626	locomotory behavior	Adora2a	IGI	MGI:MGI:94924	Mouse	PMID:16280580
Biological Process	GO:0007626	locomotory behavior	Adora2a	IGI	MGI:MGI:98735	Mouse	PMID:12538862
Biological Process	GO:0007626	locomotory behavior	Adora2a	IGI	MGI:MGI:94924	Mouse	PMID:11172060
Biological Process	GO:0007626	locomotory behavior	Adora2a	IMP		Rat	PMID:12827647\|RGD:1625682
Biological Process	GO:0051899	membrane depolarization	Adora2a	IMP		Rat	PMID:16644907\|RGD:1625443
Biological Process	GO:0046636	negative regulation of alpha-beta T cell activation	Adora2a	IDA		Mouse	PMID:10069416
Biological Process	GO:0008285	negative regulation of cell population proliferation	Adora2a	IDA		Rat	PMID:16617164\|RGD:1625626
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Adora2a	IDA		Rat	PMID:15211592\|RGD:1625666
Biological Process	GO:0050728	negative regulation of inflammatory response	Adora2a	IGI	MGI:MGI:87916	Mouse	PMID:17601796
Biological Process	GO:0040013	negative regulation of locomotion	Adora2a	IDA		Rat	PMID:12189203\|RGD:625594
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Adora2a	IDA		Rat	PMID:15211592\|RGD:1625666
Biological Process	GO:0006469	negative regulation of protein kinase activity	Adora2a	IDA		Rat	PMID:12590138\|RGD:1625697
Biological Process	GO:0043116	negative regulation of vascular permeability	Adora2a	IMP		Rat	PMID:16815983\|RGD:1625437
Biological Process	GO:0048812	neuron projection morphogenesis	Adora2a	IMP		Rat	PMID:12727227\|RGD:1625696
Biological Process	GO:0048812	neuron projection morphogenesis	Adora2a	IDA		Rat	PMID:16617164\|RGD:1625626
Biological Process	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission	Adora2a	IMP		Rat	PMID:12679375\|RGD:1625693
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Adora2a	IMP	MGI:MGI:2155985	Mouse	PMID:10845921
Biological Process	GO:0045938	positive regulation of circadian sleep/wake cycle, sleep	Adora2a	IDA		Rat	PMID:16109808\|RGD:1625234
Biological Process	GO:0014049	positive regulation of glutamate secretion	Adora2a	IDA		Rat	PMID:16481441\|RGD:1625231
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Adora2a	IMP		Rat	PMID:14596853\|RGD:1625717
Biological Process	GO:0050714	positive regulation of protein secretion	Adora2a	IDA		Rat	PMID:14742743\|RGD:1625674
Biological Process	GO:0035815	positive regulation of renal sodium excretion	Adora2a	IDA		Rat	PMID:10070140\|RGD:628573
Biological Process	GO:0035815	positive regulation of renal sodium excretion	Adora2a	IMP		Rat	PMID:10070140\|RGD:628573
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	Adora2a	IGI	MGI:MGI:94924	Mouse	PMID:10934242
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	Adora2a	IDA		Mouse	PMID:10934242
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Adora2a	IDA		Rat	PMID:16481441\|RGD:1625231
Biological Process	GO:0035810	positive regulation of urine volume	Adora2a	IMP		Rat	PMID:10070140\|RGD:628573
Biological Process	GO:0060134	prepulse inhibition	Adora2a	IMP		Rat	PMID:12827647\|RGD:1625682
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adora2a	EXP		Rat	PMID:15659214\|RGD:1625642
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adora2a	IDA		Rat	PMID:15659214\|RGD:1625642
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Adora2a	IEP		Rat	PMID:15659214\|RGD:1625642
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Adora2a	IDA		Rat	PMID:12590138\|RGD:1625697
Biological Process	GO:0051924	regulation of calcium ion transport	Adora2a	IMP		Rat	PMID:15297571\|RGD:1625662
Biological Process	GO:0060784	regulation of cell proliferation involved in tissue homeostasis	adora2aa	IMP	ZFIN:ZDB-MRPHLNO-130930-1	Zfish	PMID:22608007
Biological Process	GO:0006355	regulation of DNA-templated transcription	Adora2a	IDA		Rat	PMID:12189203\|RGD:625594
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	Adora2a	IDA		Rat	PMID:15211592\|RGD:1625666
Biological Process	GO:0014061	regulation of norepinephrine secretion	Adora2a	IMP		Rat	PMID:16539684\|RGD:1625639
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	adora2aa	IMP	ZFIN:ZDB-MRPHLNO-130930-1	Zfish	PMID:22608007
Biological Process	GO:0043279	response to alkaloid	Adora2a	IMP		Rat	PMID:16684876\|RGD:1625634
Biological Process	GO:0001975	response to amphetamine	Adora2a	IMP	MGI:MGI:2155985	Mouse	PMID:11172060
Biological Process	GO:0031000	response to caffeine	Adora2a	IDA		Rat	PMID:16481441\|RGD:1625231
Biological Process	GO:0010035	response to inorganic substance	Adora2a	IMP		Mouse	PMID:25644539
Biological Process	GO:0014074	response to purine-containing compound	ADORA2A	IDA		Human	PMID:25644539
Biological Process	GO:0014074	response to purine-containing compound	Adora2a	IMP		Mouse	PMID:25644539
Biological Process	GO:0009410	response to xenobiotic stimulus	Adora2a	IEP		Rat	PMID:17853654\|RGD:4890369
Biological Process	GO:0007271	synaptic transmission, cholinergic	Adora2a	IMP		Rat	PMID:15297571\|RGD:1625662
Biological Process	GO:0001963	synaptic transmission, dopaminergic	Adora2a	IGI	MGI:MGI:98735	Mouse	PMID:12538862
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Adora2a	IDA		Rat	PMID:16644907\|RGD:1625443
Biological Process	GO:0042311	vasodilation	Adora2a	IMP		Rat	PMID:10070140\|RGD:628573
Biological Process	GO:0042311	vasodilation	Adora2a	IMP		Rat	PMID:16601261\|RGD:1625442

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.