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Adora2a
Gene Detail
 Symbol
Name
ID
Adora2a
adenosine A2a receptor
MGI:99402
Synonyms A2AAR, A2aR, A2a, Rs, AA2AR
Feature Type protein coding gene
Genetic Map
Chromosome 10
38.52 cM, cytoband B5.3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:75316943-75334788 bp, + strand
From NCBI annotation of GRCm38

  17846 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20166  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: adenosine receptor
Gene Tree: Adora2a

Human
homologs
Human Homolog ADORA2A, adenosine A2a receptor
NCBI Gene ID 135
neXtProt AC  NX_P29274
Human Synonyms  A2aR, ADORA2, RDC8
Human Chr (Location)  22q11.23; chr22:24423597-24442360 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene are viable and fertile with reduced exploratory activity and displaying depressive rather than stimulatory response to caffeine. Mutants test more anxious, were more aggressive towards intruders, and slower to respond to pain stimuli. Blood pressure and heart rate are increased, as well as platelet aggregation rate.
 
Human Diseases Modeled Using Mouse Adora2a (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Adora2a interacts with 124 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (86 annotations)
Process adenosine receptor signaling pathway, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component asymmetric synapse, axolemma, ...
Function alpha-actinin binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (180)    Tissues (67)    Images (16)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 42
RT-PCR 138
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(16) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000020178 (Evidence)
Entrez Gene11540 (Evidence)
UniGene333734
DFCITC1582793, TC1694424
DoTSDT.101367556, DT.40166150
NIA Mouse Gene IndexU011657
Consensus CDS ProjectCCDS23924.1
International Mouse Knockout Project StatusAdora2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11540 NCBI Gene Model | MGI Sequence Detail 17846 C57BL/6J ±  kb
transcript NM_009630 RefSeq | MGI Sequence Detail 2604 Not Specified 
polypeptide Q60613 UniProt | EBI | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001513 Adenosine A2A receptor
InterPro IPR001634 Adenosine receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001576 adenosine receptor A2a
Graphical View of Protein Domain Structure
References (Earliest) J:24044 Stehle JH, et al., Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Mol Endocrinol. 1992 Mar;6(3):384-93
(Latest) J:211192 Yamaguchi H, et al., Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. Elife (Cambridge). 2014;3:e02172
All references(218)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-16163

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory