About   Help   FAQ
Adora2a Gene Detail
Summary
  • Symbol
    Adora2a
  • Name
    adenosine A2a receptor
  • Synonyms
    A2AAR, A2aR, A2a, Rs, AA2AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:99402
    NCBI Gene: 11540
  • Gene Overview
    MyGene.info: ADORA2A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:75316877-75334784 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17908 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.52 cM, cytoband B5.3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ADORA2A, adenosine A2a receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ADORA2A, adenosine A2a receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A2aR, ADORA2, RDC8
  • Links
    NCBI Gene ID: 135
    neXtProt AC: NX_P29274
    UniProt: P29274

  • Chr Location
    22q11.23; chr22:24423597-24442360 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Adora2a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    182 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene are viable and fertile with reduced exploratory activity and displaying depressive rather than stimulatory response to caffeine. Mutants test more anxious, were more aggressive towards intruders, and slower to respond to pain stimuli. Blood pressure and heart rate are increased, as well as platelet aggregation rate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020178 Ensembl Gene Model | MGI Sequence Detail 17908 C57BL/6J ±  kb
    transcript ENSMUST00000105420 Ensembl | MGI Sequence Detail 2596 Not Applicable  
    polypeptide ENSMUSP00000101060 Ensembl | MGI Sequence Detail 410 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      100 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 16
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16163
    References
    more
    • Summaries
      All 282
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 18
      Phenotypes 182
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:257011 Allard D, et al., CD73-A2a adenosine receptor axis promotes innate B cell antibody responses to pneumococcal polysaccharide vaccination. PLoS One. 2018;13(1):e0191973

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory