Adora2a
Gene Detail

Symbol Name ID

Adora2a adenosine A2a receptor MGI:99402

Synonyms

A2AAR, A2aR, A2a, Rs, AA2AR

Feature Type

protein coding gene

Genetic Map

Chromosome 10

38.52 cM, cytoband B5.3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:75316943-75334788 bp, + strand From NCBI annotation of GRCm38   17846 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20166  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adenosine receptor
Gene Tree: Adora2a

Human homologs

Human Homolog		ADORA2A, adenosine A2a receptor
NCBI Gene ID		135
neXtProt AC		NX_P29274
Human Synonyms		ADORA2, hA2aR, RDC8
Human Chr (Location)		22q11.23; chr22:24823530-24838325 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for targeted mutations that inactivate the gene are viable and fertile with reduced exploratory activity and displaying depressive rather than stimulatory response to caffeine. Mutants test more anxious, were more aggressive towards intruders, and slower to respond to pain stimuli. Blood pressure and heart rate are increased, as well as platelet aggregation rate.

 
Human Diseases Modeled Using Mouse Adora2a (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (83 annotations)

Process	adenosine receptor signaling pathway, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component	asymmetric synapse, axolemma, ...
Function	alpha-actinin binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (180)    Tissues (67)    Images (16)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	42
RT-PCR	138

cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(1) cDNA(16) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000020178 (Evidence)
Entrez Gene	11540 (Evidence)
UniGene	333734
DFCI	TC1582793, TC1694424
DoTS	DT.101367556, DT.40166150
NIA Mouse Gene Index	U011657
Consensus CDS Project	CCDS23924.1
International Mouse Knockout Project Status	Adora2a

Sequences

Length	Strain/Species
genomic	11540	NCBI Gene Model | MGI Sequence Detail	17846	C57BL/6J
transcript	NM_009630	RefSeq | MGI Sequence Detail	2534	C57BL/6
polypeptide	Q60613	UniProt | EBI | MGI Sequence Detail	410	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(81 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001513	Adenosine A2A receptor
InterPro	IPR001634	Adenosine receptor
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001576	adenosine receptor A2a

Graphical View of Protein Domain Structure

References

(Earliest) J:24044 Stehle JH, et al., Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Mol Endocrinol. 1992 Mar;6(3):384-93
(Latest) J:194258 Li H, et al., Adenosine and dopamine receptors coregulate photoreceptor coupling via gap junction phosphorylation in mouse retina. J Neurosci. 2013 Feb 13;33(7):3135-50
All references(194)

Other accession IDs

MGD-MRK-16163