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Fgfr2 Gene Detail
Summary
  • Symbol
    Fgfr2
  • Name
    fibroblast growth factor receptor 2
  • Synonyms
    Bek, Fgfr-2, Fgfr2b, Fgfr-7, Fgfr7, KGFRTr, svs
  • Feature Type
    protein coding gene
  • IDs
    MGI:95523
    NCBI Gene: 14183
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:129764181-129868538 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 73.19 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2850 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95523
 protein coding gene Chr7:129764181-132725079 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033090
 protein coding gene Chr7:134667329-134775531 (-)
A/J MGP_AJ_G0033072
 protein coding gene Chr7:130997243-131108181 (-)
AKR/J MGP_AKRJ_G0033004
 protein coding gene Chr7:134483684-134592301 (-)
BALB/cJ MGP_BALBcJ_G0033073
 protein coding gene Chr7:130676817-130780908 (-)
C3H/HeJ MGP_C3HHeJ_G0032787
 protein coding gene Chr7:134362330-134469420 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033583
 protein coding gene Chr7:139863465-139977551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030555
 protein coding gene Chr7:132175024-132279477 (-)
CAST/EiJ MGP_CASTEiJ_G0032117
 protein coding gene Chr7:126168763-126277865 (-)
CBA/J MGP_CBAJ_G0032760
 protein coding gene Chr7:144645815-144759823 (-)
DBA/2J MGP_DBA2J_G0032912
 protein coding gene Chr7:129000333-129104550 (-)
FVB/NJ MGP_FVBNJ_G0032865
 protein coding gene Chr7:128859552-128967858 (-)
LP/J MGP_LPJ_G0033006
 protein coding gene Chr7:136144069-136251933 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032897
 protein coding gene Chr7:145629400-145736428 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033602
 protein coding gene Chr7:133418350-133532579 (-)
PWK/PhJ MGP_PWKPhJ_G0031823
 protein coding gene Chr7:122059626-122170384 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031669
 protein coding gene Chr7:120250019-120360485 (-)
WSB/EiJ MGP_WSBEiJ_G0032228
 protein coding gene Chr7:134416681-134523175 (-)



Homology
more
  • Human Ortholog
    FGFR2, fibroblast growth factor receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGFR2, fibroblast growth factor receptor 2
  • Synonyms
    BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, K-SAM, TK14, TK25
  • Links
    NCBI Gene ID: 2263
    UniProt: P21802

  • Chr Location
    10q26.13; chr10:121478330-121598458 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with Fgfr2 mouse models; 19 with human FGFR2 associations

Human Disease Mouse Models
      
IDs
 View 8 models
IDs
 View 1 model
IDs
 View 4 models
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    12 with disease annotations
  • References
    15 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    389 phenotypes from 28 alleles in 38 genetic backgrounds
    76 phenotypes from multigenic genotypes
    29 images
    340 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations die as embryos. Isoform IIIb deficient mutants die at birth with defects in multiple organs and tissues. Isoform IIIc deficient mutants have defects in osteoblast and chondrocyte lineages, producing dwarfism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    229
  • GO References
    56
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2379
  • Tissues
    860
  • cDNA Data
    887
  • Literature Summary
    451
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14183 NCBI Gene Model | MGI Sequence Detail 104358 C57BL/6J ±  kb
    transcript NM_010207 RefSeq | MGI Sequence Detail 5223 C57BL/6  
    polypeptide P21803 UniProt | EBI | MGI Sequence Detail 821 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1006
      Genomic 4
      cDNA 896
      Primer pair 58
      Other 48

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14668, MGD-MRK-1537, MGD-MRK-9777, MGD-MRK-9780, MGD-MRK-9782, MGD-MRK-9785, MGI:2142159, MGI:2142264, MGI:98454
    References
    more
    • Summaries
      All 817
      Developmental Gene Expression 451
      Diseases 15
      Gene Ontology 56
      Phenotypes 340
    • Earliest
      J:9441 Shukri NM, et al., Recessive mutation in a standard recombinant-inbred line of mice affects seminal vesicle shape. Genet Res. 1988 Aug;52(1):27-32
    • Latest
      J:371773 Wang Q, et al., FGF-induced phospholipase Cgamma signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism. Cell Rep. 2025 Aug 26;44(8):116046
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory