Phenotypes Associated with This Genotype

Genotype
MGI:8288884

• Allelic Composition: Fgfr2^em1Xijin/Fgfr2⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal coronal suture morphology ( J:378157 )

• early senescence of suture progenitor cells (SPCs)

• enhanced osteogenic differentiation of suture progenitor cells (SPCs)

short face ( J:378157 )

shortened head ( J:378157 )

growth/size/body

short face ( J:378157 )

shortened head ( J:378157 )

skeleton

abnormal coronal suture morphology ( J:378157 )

• early senescence of suture progenitor cells (SPCs)

• enhanced osteogenic differentiation of suture progenitor cells (SPCs)

delayed sagittal suture closure ( J:378157 )

premature coronal suture closure ( J:378157 )

vision/eye

exophthalmos ( J:378157 )

ocular hypertelorism ( J:378157 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Crouzon syndrome		DOID:2339	OMIM:123500	J:378157