Fgfr2^em1Xijin
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fgfr2^em1Xijin
• Name: fibroblast growth factor receptor 2; endonuclease-mediated mutation 1, Xiaolei Jin
• MGI ID: MGI:8288862
• Synonyms: Fgfr2^C361Y
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^em1Xijin page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Cysteine codon 361 (TGC) was changed to tyrosine (TAC) (p.C361Y) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation is the equivalent of the human p.C342Y mutation associated with Crouzon syndrome and in heterozygous mice the mutation allele causes similar craniofacial phenotypes. (J:378157)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 91 strains or lines available

References

• Original: J:378157 Chen Z, et al., P38alpha MAPK-induced senescence in cranial suture progenitor cells promotes craniosynostosis. Commun Biol. 2025 Dec 13;9(1):83
• All: 2 reference(s)