65 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Aicdatm1Hon/Aicdatm1Hon Ighmtm1.1(IGH-2)Cog/Ighm+ involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N	abnormal B cell physiology	J:157575
Atmintm1.1Jhh/Atmintm1.1Jhh Ighmtm1(Bcl6)Rdf/Ighm+ Tg(Fcer2a-cre)5Mbu/0 B6.Cg-Atmintm1.1Jhh Ighmtm1(Bcl6)Rdf Tg(Fcer2a-cre)5Mbu	abnormal tumor susceptibility	J:230105
Atp11cm1Btlr/Y Tg(IghmHyHEL10,IgkHyHEL10)4Ccg/0 involves: C57BL/6 * C57BL/6J * C57BL/6JSfdAnu	decreased B cell number	J:171925
Bcl6tm2Rdf/Bcl6tm2Rdf Ighmtm1(Bcl6)Rdf/? involves: 129/Sv * 129S1/Sv * C57BL/6	abnormal immune system morphology	J:98937
	abnormal spleen germinal center morphology	J:98937
Faslpr/Faslpr Ighmtm1Cgn/Ighmtm1Cgn involves: 129S2/SvPas * C57BL/6 * MRL/Mp	abnormal humoral immune response	J:119584
	abnormal immunoglobulin level	J:119584
	arrested B cell differentiation	J:119584
	decreased IgM level	J:119584
	decreased mature B cell number	J:119584
	enlarged lymph nodes	J:119584
	increased autoantibody level	J:119584
	increased T cell number	J:119584
	increased urine protein level	J:119584
Faslgld/Faslgld Ighmtm1Cgn/Ighmtm1Cgn involves: 129S2/SvPas * C3H/HeJ * C57BL/6	normal immune system phenotype	J:119584
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru Ighmtm1Cgn/Ighmtm1Cgn Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell NOD.Cg-Ighmtm1Cgn H2-Ab1b-tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell	abnormal PR interval	J:113267
	enlarged heart	J:113267
	heart inflammation	J:113267
Ighmtm1(Bcl6)Rdf/? involves: 129/Sv * C57BL/6	abnormal B cell proliferation	J:98937
	abnormal spleen B cell follicle morphology	J:98937
	abnormal spleen morphology	J:98937
	decreased immunoglobulin level	J:98937
	decreased plasma cell number	J:98937
	enlarged spleen	J:98937
	increased B cell derived lymphoma incidence	J:98937
	increased spleen germinal center number	J:98937
	increased spleen white pulp amount	J:98937
	premature death	J:98937
Ighmtm1Cgn/Ighm+ Tgfb1tm1Doe/Tgfb1tm1Doe involves: 129S2/SvPas * C57BL/6 * CF-1	increased cell proliferation	J:99033
	thymus hypoplasia	J:99033
Ighmtm1Cgn/Ighm+ Tg(Igh-6/Igh-V281)3Jwt/0 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt	insulitis	J:91865
Ighmtm1Cgn/Ighm+ Tg(Igh-6/Igh-V125)2Jwt/0 Tg(Igk-C/Igk-V125)1Jwt/0 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt	increased circulating glucose level	J:91865
	increased susceptibility to autoimmune diabetes	J:91865
	insulitis	J:91865
Ighmtm1Cgn/Ightm3Tim involves: 129 * C57BL/6	abnormal B cell differentiation	J:102308
	decreased B cell number	J:102308
Ighmtm1Cgn/Ighmtm1Cgn Igkctm1Bgmn/Igkctm1Bgmn Igltm2.1Bgmn/Igltm2.1Bgmn involves: 129	decreased IgG level	J:130864
	decreased IgM level	J:130864
Ighmtm1Cgn/Ighmtm1Cgn Irf2tm1Mak/Irf2tm1Mak involves: 129S2/SvPas * C57BL/6	abnormal skin condition	J:66034
Ighmtm1Cgn/Ighmtm1Cgn Nlrp1aNeut1/Nlrp1aNeut1 involves: 129S2/SvPas * C57BL/6	normal immune system phenotype	J:191055
Ighmtm1Cgn/Ighmtm1Cgn Ptpn6me-v/Ptpn6me-v involves: 129S7/SvEvBrd * C57BL/6J	decreased retina photoreceptor cell number	J:108375
	retina photoreceptor degeneration	J:108375
Ighmtm1Cgn/Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt/0 Tg(Igk-C/Igk-V125)1Jwt/0 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt	insulitis	J:91865
Ighmtm1Cgn/Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt/0 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt	insulitis	J:91865
Ighmtm1Cgn/Ighmtm1Cgn Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg NOD.Cg-Ighmtm1Cgn Tg(IghelMD4)4Ccg/DvsJ	abnormal B lymphocyte antigen presentation	J:80859
	abnormal mature B cell morphology	J:80859
	abnormal T cell proliferation	J:80859
	decreased CD8-positive, alpha-beta T cell number	J:80859
	decreased susceptibility to autoimmune diabetes	J:80859
	increased lymphoma incidence	J:80859
	insulitis	J:80859
Ighmtm1Cgn/Ighmtm1Cgn Tg(IghMyc)22Bri/0 involves: 129S2/SvPas * C57BL * SJL	increased lymphoma incidence	J:187318
Ighmtm1Cgn/Ighmtm1Cgn Tg(Ins2-Cxcl13)1Cys/0 involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal pancreatic islet morphology	J:110548
Ighmtm1Cgn/Ighmtm1Cgn Tg(TcraR28,TcrbR28)KRNDim/0 involves: 129S2/SvPas * C57BL/6 * NOD * SJL	normal immune system phenotype	J:36815
Ighmtm1Cgn/Ighmtm1Cgn Tgfb1tm1Doe/Tgfb1tm1Doe involves: 129S2/SvPas * C57BL/6 * CF-1	abnormal inflammatory response	J:99033
	cachexia	J:99033
	premature death	J:99033
	thymus hypoplasia	J:99033
Ighmtm1Cgn/Ighmtm1Cgn Tnftm2Gkl/Tnf+ involves: 129S/SvEv * 129S2/SvPas * C57BL/6J	small intestinal inflammation	J:108572
Ighmtm1Cgn/Ighmtm1Cgn Trex1tm1Tld/Trex1tm1Tld involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	cardiac fibrosis	J:181257
	increased inflammatory response	J:181257
	kidney inflammation	J:181257
	myocarditis	J:181257
	premature death	J:181257
	normal renal/urinary system phenotype	J:181257
	tubular nephritis	J:181257
Ighmtm1Cgn/Ighmtm1Cgn Unc93b1tm1.1Kmiy/Unc93b1tm1.1Kmiy involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	normal hematopoietic system phenotype	J:174308
	normal mortality/aging	J:174308
	thrombocytopenia	J:174308
Ighmtm1Cgn/Ighmtm1Cgn X/Yaa BXSB.129S2(B6)-Ighmtm1Cgn/Dcr	decreased susceptibility to systemic lupus erythematosus	J:206236
Ighmtm1Msn/Ighmtm1Msn Tg(Igh-6)1Msn/? B6.129S-Ighmtm1Msn	abnormal B-1a B cell morphology	J:80656
	abnormal splenic cell ratio	J:80656
	decreased follicular B cell number	J:80656
	decreased IgM level	J:80656
	increased marginal zone B cell number	J:80656
Ighmtm3Bgmn/Ighmtm3Bgmn Igkctm1Bgmn/Igkctm1Bgmn Igltm2.1Bgmn/Igltm2.1Bgmn involves: 129P2/OlaHsd * 129/Sv	abnormal B cell differentiation	J:130864
	decreased IgG level	J:130864
	decreased IgM level	J:130864
Tg(Igh-3/Igh-6VD93)1241Ust/? C57BL/6-Tg(Igh-3/Igh-6VD93)1241Ust	abnormal B cell morphology	J:135209
	decreased pre-B cell number	J:135209
Tg(Igh-6/Igh-V125)2Jwt/0 Tg(Igk-C/Igk-V125)1Jwt/0 NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt	abnormal B cell number	J:91865
	increased circulating glucose level	J:91865
	increased susceptibility to autoimmune diabetes	J:91865
	insulitis	J:91865
Tg(Igh-6/Igh-V281)3Jwt/0 NOD.B6-Tg(Igh-6/Igh-V281)3Jwt	decreased susceptibility to autoimmune diabetes	J:91865
	insulitis	J:91865