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Targeted Allele Detail
Symbol: Ighmtm1(Bcl6)Rdf
Name: immunoglobulin heavy constant mu; targeted mutation 1, Riccardo Dalla-Favera
MGI ID: MGI:3581517
Synonyms: ImuHABCL6
Gene: Ighm  Location: Chr12:113382446-113386350 bp, - strand  Genetic Position: Chr12, 62.1 cM, cytoband F1-2
Alliance: Ighmtm1(Bcl6)Rdf page
Germline Transmission:  Earliest citation of germline transmission: J:98937
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsAn HA-tagged Bcl6 cDNA was inserted downstream of the Imu promoter such that the Bcl6 would be expressed in active mature B cells. (J:98937)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Tumor Data
List all tumor models in MMHCdb carrying Ighmtm1(Bcl6)Rdf
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ighm Mutation:  36 strains or lines available
Original:  J:98937 Cattoretti G, et al., Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell. 2005 May;7(5):445-55
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory