Ighm^tm1(Bcl6)Rdf
Targeted Allele Detail

Summary

• Symbol: Ighm^tm1(Bcl6)Rdf
• Name: immunoglobulin heavy constant mu; targeted mutation 1, Riccardo Dalla-Favera
• MGI ID: MGI:3581517
• Synonyms: ImuHABCL6
• Gene: Ighm Location: Chr12:113382446-113386350 bp, - strand Genetic Position: Chr12, 62.1 cM, cytoband F1-2
• Alliance: Ighm^tm1(Bcl6)Rdf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98937
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: An HA-tagged Bcl6 cDNA was inserted downstream of the Imu promoter such that the Bcl6 would be expressed in active mature B cells. (J:98937)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Ighm^tm1(Bcl6)Rdf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ighm Mutation: 55 strains or lines available

References

• Original: J:98937 Cattoretti G, et al., Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell. 2005 May;7(5):445-55
• All: 20 reference(s)