Phenotypes associated with this allele
neoplasm
|
|
• mice exhibit similar tumorigenesis as Atmintm1.1Jhh/Atmintm1.1Jhh Tg(Fcer2a-cre)5Mbu mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6tm2Rdf mutation
(0 available);
any
Bcl6 mutation
(55 available)
Ighmtm1(Bcl6)Rdf mutation
(1 available);
any
Ighm mutation
(55 available)
|
|
|
immune system
|
|
• Igh-6tm1(Bcl6)Rdf was unable to rescue the inflammatory phenotype observed in homozygous Bcl6 null mice
|
|
|
• although proliferation of B cells expressing germinal center markers was induced, the cells did not aggregate in typical germinal center structures
|
hematopoietic system
|
|
• although proliferation of B cells expressing germinal center markers was induced, the cells did not aggregate in typical germinal center structures
|
Allelic
Composition |
Ighmtm1(Bcl6)Rdf/?
|
|
Genetic
Background |
involves: 129/Sv * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1(Bcl6)Rdf mutation
(1 available);
any
Ighm mutation
(55 available)
|
|
|
mortality/aging
|
|
• showed increased mortality at about 13 months of age and only about 80% survived at 15 months
|
immune system
|
|
• 42% exhibited abnormal B cell expansions involving predominately the spleen but also the lymph nodes compared to 11% in wild-type and displayed features of benign lymphoproliferative disease
|
|
|
• about a 30% reduction in the number of total plasmacytoid cells (B220+/- CD138+), mainly due to a decrease in post-CSR plasma cells (IgM-IgD-), while IgM+IgD+ plasma cells were normal
|
|
|
• 17% displayed a complete effacement of the splenic lymphoid architecture due to the proliferation of large lymphoid cells
|
|
|
• 17% exhibited a modest splenomegaly at 6 months of age
|
|
|
• partial effacement of the follicular architecture with the appearance of blast cells
|
|
|
• nonimmunized mutant mice displayed an increased number of germinal centers, comparable to that observed upon immunization in wild-type mice, and the increase in the number of germinal centers and an increase in the total germinal center area persisted after immunization
|
|
|
• expanded white pulp composed predominately of B cells, but also included disorganized accumulations of other cell types such as T cells and dendritic cells
|
|
|
• displayed a small (20-50%) reduction in total serum immunoglobulin levels of all subclasses, except for IgM, both under basal conditions and after immunization with T-dependent antigens
|
neoplasm
|
|
• between 15 and 20 months, 36-62% developed clonal B cell lymphomas, predominately of splenic orgin, with or without nodal involvement
• tumors displayed a mature B cell phenotype and most were histologically reminiscent of human diffuse large B cell lymphomas and contained clonal karyotypic aberrations
|
hematopoietic system
|
|
• 42% exhibited abnormal B cell expansions involving predominately the spleen but also the lymph nodes compared to 11% in wild-type and displayed features of benign lymphoproliferative disease
|
|
|
• about a 30% reduction in the number of total plasmacytoid cells (B220+/- CD138+), mainly due to a decrease in post-CSR plasma cells (IgM-IgD-), while IgM+IgD+ plasma cells were normal
|
|
|
• 17% displayed a complete effacement of the splenic lymphoid architecture due to the proliferation of large lymphoid cells
|
|
|
• 17% exhibited a modest splenomegaly at 6 months of age
|
|
|
• partial effacement of the follicular architecture with the appearance of blast cells
|
|
|
• nonimmunized mutant mice displayed an increased number of germinal centers, comparable to that observed upon immunization in wild-type mice, and the increase in the number of germinal centers and an increase in the total germinal center area persisted after immunization
|
|
|
• expanded white pulp composed predominately of B cells, but also included disorganized accumulations of other cell types such as T cells and dendritic cells
|
|
|
• displayed a small (20-50%) reduction in total serum immunoglobulin levels of all subclasses, except for IgM, both under basal conditions and after immunization with T-dependent antigens
|
growth/size/body
|
|
• 17% exhibited a modest splenomegaly at 6 months of age
|
cellular
|
|
• 42% exhibited abnormal B cell expansions involving predominately the spleen but also the lymph nodes compared to 11% in wild-type and displayed features of benign lymphoproliferative disease
|
Analysis Tools
