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Faslgld
Spontaneous Allele Detail
Summary
Symbol: Faslgld
Name: Fas ligand; generalized lymphoproliferative disease
MGI ID: MGI:1856384
Synonyms: CD95-, FasL-, gld, Tnfsf6gld
Gene: Fasl  Location: Chr1:161608260-161616064 bp, - strand  Genetic Position: Chr1, 69.95 cM
Alliance: Faslgld page
control and Faslgld/Faslgld

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C3H/HeJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA T-to-C transition point mutation near the 3' end of the coding sequence causes a replacement of a highly conserved phenylalanine with a leucine at position 273 (p.F273L) in the extracellular region of the encoded protein. (J:17445)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Faslgld
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Fasl Mutation:  37 strains or lines available
References
Original:  J:29572 Murphy ED, et al., Generalized lymphoproliferative disease (gld). Mouse News Lett. 1982;67:20-1
All:  366 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory