About   Help   FAQ
Fasl Gene Detail
Summary
  • Symbol
    Fasl
  • Name
    Fas ligand
  • Synonyms
    APT1LG1, CD178, CD95L, Fasl, Fas-L, Tnfsf6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99255
    NCBI Gene: 14103
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:161608260-161616064 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.95 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    287 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99255
 protein coding gene Chr1:161608258-161616064 (-)
129S1/SvImJ ENSMUSG00200005189
 protein coding gene Chr1:159113103-159120933 (-)
A/J ENSMUSG00195018828
 protein coding gene Chr1:158429413-158437241 (-)
AKR/J ENSMUSG00220013174
 protein coding gene Chr1:158219052-158226860 (-)
BALB/cJ ENSMUSG00180034448
 protein coding gene Chr1:158692335-158700125 (-)
C3H/HeJ ENSMUSG00175039153
 protein coding gene Chr1:158748085-158755877 (-)
C57BL/6NJ ENSMUSG00215015506
 protein coding gene Chr1:158627268-158635073 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014766
 protein coding gene Chr1:152373329-152381550 (-)
CAST/EiJ ENSTCUG00005020215
 protein coding gene Chr1:157278756-157286552 (-)
CBA/J ENSMUSG00210020292
 protein coding gene Chr1:158646088-158653922 (-)
DBA/2J ENSMUSG00185010906
 protein coding gene Chr1:162909792-162917582 (-)
FVB/NJ ENSMUSG00205009861
 protein coding gene Chr1:157714077-157721883 (-)
JF1/MsJ ENSUMUG00000009124
 protein coding gene Chr1:162070957-162078748 (-)
LP/J ENSMUSG00230011850
 protein coding gene Chr1:162510936-162518772 (-)
NOD/ShiLtJ ENSMUSG00190024170
 protein coding gene Chr1:158465789-158473595 (-)
NZO/HlLtJ ENSMUSG00225004027
 protein coding gene Chr1:166118566-166126358 (-)
PWK/PhJ ENSLUMG00010037324
 protein coding gene Chr1:157452984-157461162 (-)
SPRET/EiJ ENSMSPG00010041903
 protein coding gene Chr1:160840681-160847837 (-)
WSB/EiJ ENSIUOG00005015199
 protein coding gene Chr1:158024610-158032442 (-)



Homology
more
  • Human Ortholog
    FASLG, Fas ligand
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FASLG, Fas ligand
  • Synonyms
    ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A
  • Links
    NCBI Gene ID: 356
    UniProt: P48023

  • Chr Location
    1q24.3; chr1:172659102-172666876 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Fasl mouse models; 12 with human FASLG associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 3 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    94 phenotypes from 12 alleles in 18 genetic backgrounds
    26 phenotypes from multigenic genotypes
    1 images
    403 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele, knock-out allele, or allele producting only the soluble isoform exhibit premature death due to the development of systemic lupus erythematosus, autoimmune glomerulonephritis, hepatomegaly, lymphadenopathy, and hypergammaglobulinaemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    104
  • cDNA Data
    32
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14103 NCBI Gene Model | MGI Sequence Detail 7805 C57BL/6J ±  kb
    transcript NM_010177 RefSeq | MGI Sequence Detail 1935 ZRU/MplStud  
    polypeptide P41047 UniProt | EBI | MGI Sequence Detail 279 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 4
      cDNA 32
      Primer pair 7
      Antibodies 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10104, MGD-MRK-16013
    References
    more
    • Summaries
      All 851
      Developmental Gene Expression 25
      Diseases 6
      Gene Ontology 18
      Phenotypes 403
    • Earliest
      J:7306 Roths JB, et al., A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. J Exp Med. 1984 Jan 1;159(1):1-20
    • Latest
      J:389308 Janova H, et al., West Nile virus triggers intestinal dysmotility via T cell-mediated enteric nervous system injury. J Clin Invest. 2024 Aug 29;134(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory