94 phenotypes from 12 alleles in 18 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fasldel1Hong/Fasldel1Hong either: (involves: 129 * BALB/c * C57BL/6) or (involves: 129X1/SvJ * C3H/HeJ * C57BL/6)	abnormal definitive hematopoiesis	J:112563
	abnormal thymus cell ratio	J:112563
	enlarged lymph nodes	J:112563
	enlarged spleen	J:112563
	enlarged thymus	J:112563
	increased IgG level	J:112563
	increased IgM level	J:112563
	increased lymphoma incidence	J:112563
	increased metastatic potential	J:112563
	premature death	J:112563
Faslgld/Faslgld B6.C3-Faslgld	abnormal lymph node morphology	J:91058
	normal cardiovascular system phenotype	J:91058
	enlarged lymph nodes	J:91058
	enlarged spleen	J:91058
	normal homeostasis/metabolism phenotype	J:91058
	impaired macrophage phagocytosis	J:91058
	increased anti-nuclear antigen antibody level	J:91058
	increased apoptosis	J:91058
	increased autoantibody level	J:91058
	increased spleen weight	J:91058
Faslgld/Faslgld B6Smn.C3-Faslgld/J	abnormal eye electrophysiology	J:136745
	abnormal hepatocyte morphology	J:135830
	abnormal male germ cell apoptosis	J:146994
	abnormal NK cell physiology	J:115033
	abnormal osteoclast physiology	J:127179
	brain inflammation	J:120427
	CNS inflammation	J:120427
	decreased circulating alanine transaminase level	J:135830
	decreased granulocyte number	J:136745
	decreased hepatocyte apoptosis	J:135830
	demyelination	J:120427
	eye inflammation	J:136745
	focal hepatic necrosis	J:135830
	increased sperm number	J:146994
	increased susceptibility to bacterial infection	J:136745
	increased susceptibility to Picornaviridae infection	J:120427
	liver inflammation	J:135830
Faslgld/Faslgld C3H/HeJ-Faslgld	abnormal interleukin level	J:8267
	abnormal T cell morphology	J:8267
	abnormal T cell physiology	J:8267
	abnormal T cell proliferation	J:8267
	decreased neuron apoptosis	J:124252
Faslgld/Faslgld C3H/HeJ-Faslgld/J	abnormal lymph node morphology	J:7306
	abnormal T cell differentiation	J:8267, J:12002
	anemia	J:7306
	normal cardiovascular system phenotype	J:7306
	decreased B cell number	J:29572
	decreased cytotoxic T cell cytolysis	J:17698
	enlarged lymph nodes	J:7306, J:29572
	enlarged spleen	J:7306, J:29572
	increased anti-double stranded DNA antibody level	J:7306
	increased anti-nuclear antigen antibody level	J:7306, J:29572
	increased autoantibody level	J:7306
	increased IgA level	J:7306, J:29572
	increased IgG1 level	J:7306
	increased IgG2a level	J:7306
	increased IgG2b level	J:7306
	increased IgG level	J:29572
	increased IgM level	J:7306, J:29572
	increased immunoglobulin level	J:7306, J:29572
	increased leukocyte cell number	J:7306
	increased lymphocyte cell number	J:7306, J:29572
	increased neutrophil cell number	J:7306
	increased T cell number	J:29572
	interstitial pneumonia	J:7306
	normal mortality/aging	J:120650
	normal neoplasm	J:108303
	premature death	J:7306, J:29572
	normal renal/urinary system phenotype	J:7306
	skin edema	J:7306
Faslgld/Faslgld involves: C3H/HeJ	abnormal osteoclast physiology	J:156947
	enlarged lymph nodes	J:171440
	enlarged spleen	J:171440
	increased spleen weight	J:171440
Faslgld/Faslgld involves: C3H/HeJ * C57BL/6	decreased susceptibility to injury	J:76811
	dermatitis	J:153501
	enlarged lymph nodes	J:153501
	enlarged spleen	J:153501
	normal immune system phenotype	J:153501
	increased anti-nuclear antigen antibody level	J:153501
	increased circulating tumor necrosis factor level	J:153501
	increased histiocytic sarcoma incidence	J:153501
	increased IgE level	J:153501
	increased IgG1 level	J:153501
	increased IgG2a level	J:153501
	increased IgG2b level	J:153501
	increased IgG level	J:153501
	increased susceptibility to systemic lupus erythematosus	J:153501
	increased T cell number	J:153501
	premature death	J:153501
Faslgld/Faslgld involves: C3H/HeJ * CBA	normal reproductive system phenotype	J:114219
Faslm1Btlr/Faslm1Btlr C57BL/6J-Faslm1Btlr	abnormal humoral immune response	J:212067
Faslm2Btlr/Faslm2Btlr C57BL/6J-Faslm2Btlr	decreased IgG level	J:224659
	impaired humoral immune response	J:224659
Fasltm1.1Ast/Fasltm1.1Ast involves: BALB/cJ * C57BL/6	decreased cytotoxic T cell cytolysis	J:153501
	dermatitis	J:153501
	enlarged lymph nodes	J:153501
	enlarged spleen	J:153501
	glomerular crescent	J:153501
	glomerulonephritis	J:153501
	normal immune system phenotype	J:153501
	increased anti-double stranded DNA antibody level	J:153501
	increased anti-nuclear antigen antibody level	J:153501
	increased circulating tumor necrosis factor level	J:153501
	increased histiocytic sarcoma incidence	J:153501
	increased IgA level	J:153501
	increased IgE level	J:153501
	increased IgG1 level	J:153501
	increased IgG2a level	J:153501
	increased IgG2b level	J:153501
	increased IgG level	J:153501
	increased IgM level	J:153501
	increased immunoglobulin level	J:153501
	increased liver tumor incidence	J:153501
	increased susceptibility to systemic lupus erythematosus	J:153501
	premature death	J:153501
	renal cast	J:153501
Fasltm1.1Bksa/Fasltm1.1Bksa involves: 129	abnormal retina ganglion cell morphology	J:171440
	enlarged lymph nodes	J:171440
	enlarged spleen	J:171440
	increased spleen weight	J:171440
Fasltm1.1Cgm/Fasltm1.1Cgm involves: 129S2/SvPas * C57BL/6 * C57BL/6N	normal immune system phenotype	J:168406
	increased B cell proliferation	J:168406
	increased germinal center B cell number	J:168406
	increased IgM level	J:168406
	increased plasma cell number	J:168406
	increased T cell proliferation	J:168406
Fasltm1.1Lest/Fasltm1.1Lest B6.129-Fasltm1.1Lest	glomerulonephritis	J:87990
	increased urine protein level	J:87990
Fasltm1.1Lest/Fasltm1.1Lest involves: 129 * C57BL/6	abnormal double-negative T cell morphology	J:87990
	abnormal lymph node morphology	J:87990
	abnormal salivary gland morphology	J:87990
	autoimmune response	J:87990
	enlarged liver	J:87990
	enlarged lymph nodes	J:87990
	enlarged spleen	J:87990
	glomerulonephritis	J:87990
	increased IgG level	J:87990
	increased urine protein level	J:87990
	lymphoid hyperplasia	J:87990
	premature death	J:87990
Fasltm1Lest/Fasltm1Lest involves: 129/Sv * C57BL/6	no abnormal phenotype detected	J:87990
Fasltm2.1Ast/Fasltm2.1Ast involves: BALB/cJ * C57BL/6	abnormal cytotoxic T cell physiology	J:153501
	normal mortality/aging	J:153501
Fasltm2.1Bksa/Fasltm2.1Bksa D2.129-Fasltm2.1Bksa	abnormal retina nerve fiber layer morphology	J:171440
	retina ganglion cell degeneration	J:171440
	normal vision/eye phenotype	J:171440
Fasltm2.1Bksa/Fasltm2.1Bksa involves: 129 * C57BL/6	abnormal retina nerve fiber layer morphology	J:171440
	decreased retina ganglion cell number	J:171440
	increased retina apoptosis	J:171440
	retina ganglion cell degeneration	J:171440
	normal vision/eye phenotype	J:171440
Tg(Ins2-Fasl)24Ach/0 NOD-Tg(Ins2-Fasl)24Ach/J	abnormal pancreatic islet morphology	J:78679
	increased susceptibility to autoimmune diabetes	J:78679, J:81416