Fasl^tm1.1Lest
Targeted Allele Detail

Summary

• Symbol: Fasl^tm1.1Lest
• Name: Fas ligand; targeted mutation 1.1, Matthieu Levi-Strauss
• MGI ID: MGI:3032864
• Synonyms: FasL^-
• Gene: Fasl Location: Chr1:161608260-161616064 bp, - strand Genetic Position: Chr1, 69.95 cM
• Alliance: Fasl^tm1.1Lest page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87990
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The neomycin selection cassette and the entire coding region were deleted from Tnfsf6^tm1Lest by cre-mediated recombination of a flanking loxP sites. (J:87990)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fasl Mutation: 36 strains or lines available

References

• Original: J:87990 Karray S, et al., Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele. J Immunol. 2004 Feb 15;172(4):2118-25
• All: 5 reference(s)