Fasl^tm2.1Ast
Targeted Allele Detail

Summary

• Symbol: Fasl^tm2.1Ast
• Name: Fas ligand; targeted mutation 2.1, Andreas Strasser
• MGI ID: MGI:4366051
• Synonyms: FasL^deltas
• Gene: Fasl Location: Chr1:161608260-161616064 bp, - strand Genetic Position: Chr1, 69.95 cM
• Alliance: Fasl^tm2.1Ast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153501
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The protion of the gene encoding the metalloprotease-cleavage site was mutated (SSFEKQI to SEEAAAI) preventing the production of the soluble peptide. However, the membrane version is still produced. The floxed neo cassette used for selection purposes was removed by germ line, cre mediated recombination. (J:153501)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fasl Mutation: 36 strains or lines available

References

• Original: J:153501 O' Reilly LA, et al., Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature. 2009 Oct 1;461(7264):659-63
• All: 3 reference(s)