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Spontaneous Allele Detail
Symbol: Ptpn6me-v
Name: protein tyrosine phosphatase, non-receptor type 6; viable motheaten
MGI ID: MGI:1856074
Synonyms: Hcphme-v, mev, mev, motheaten viable, Ptpn6mev
Gene: Ptpn6  Location: Chr6:124697670-124715672 bp, - strand  Genetic Position: Chr6, 59.17 cM
Alliance: Ptpn6me-v page
Phenotype of the Ptpn6me-v/Ptpn6me-v mouse

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Allele Type:    Spontaneous (Hypomorph)
Mutation:    Single point mutation
Mutation detailsA T-to-A transversion point mutation on the coding negative strand (g.chr6:124727383A>T on build GRCm38) at a splice consensus site (G-GT>G-GA) results in the use of two other cryptic sites. One site would result in five amino acids being deleted from the encoded protein and the other would include 69bp of intronic sequence, coding for 23 amino acids, in the transcript. (J:11892, J:42157)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Ptpn6me-v
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ptpn6 Mutation:  36 strains or lines available
Original:  J:7531 Shultz LD, et al., Viable motheaten, a new allele at the motheaten locus. I. Pathology. Am J Pathol. 1984 Aug;116(2):179-92
All:  109 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory