Ighm^{tm1.1(IGH-2)Cog}
Targeted Allele Detail

Summary

• Symbol: Ighm^{tm1.1(IGH-2)Cog}
• Name: immunoglobulin heavy constant mu; targeted mutation 1.1, Michel Cogne
• MGI ID: MGI:4437126
• Synonyms: alpha1KI
• Gene: Ighm Location: Chr12:113382446-113386350 bp, - strand Genetic Position: Chr12, 62.1 cM, cytoband F1-2
• Alliance: Ighm^{tm1.1(IGH-2)Cog} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157575
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted Mutations: Insertion, Intragenic deletion Mutation details: The human alpha 1 heavy chain was inserted into the Imu CH intron replacing Smu. A floxed neo cassette inserted downstream of the inserted sequence was removed by cre mediated recombination. (J:157575)

Generation of the Ighm^tm1.1(IGH-2)Cog allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighm Mutation: 55 strains or lines available

References

• Original: J:157575 Duchez S, et al., Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3064-9
• All: 9 reference(s)