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Transgene Detail
Symbol: Tg(TcraR28,TcrbR28)KRNDim
Name: transgene insertion KRN, Diane Mathis
MGI ID: MGI:3767242
Synonyms: K/B, KRN, KRN-TCR
Transgene: Tg(TcraR28,TcrbR28)KRNDim  Location: unknown  
Alliance: Tg(TcraR28,TcrbR28)KRNDim page
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(TcraR28,TcrbR28)KRNDim expresses 2 genes
Mutation detailsThe sequences of the variable regions of the TCR alpha and beta chains of the R28 hybridoma with rearranged Va4Ja27 and Vb6Jb1.5 genomic DNA fragments were amplified and cloned into TCR expression cassettes. Transgene-derived clones are transcribed under the control of the natural TCR alpha and -beta promoter/enhancer elements. A single founder (KRN) in which TCRalpha and Tcrbeta transgenes were cointegrated was identified. These constructs together express a T cell receptor that recognizes the 41-61 peptide of bovine pancreas ribonuclease (RNase) in the context of Ak. (J:36815)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:36815 Kouskoff V, et al., Organ-specific disease provoked by systemic autoimmunity. Cell. 1996 Nov 29;87(5):811-22
All:  97 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory