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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Myd88
myeloid differentiation primary response gene 88
MGI:108005
119 phenotypes from 14 alleles in 22 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Myd88em1.1Rsky/Myd88+
involves: C57BL/6NTac 		abnormal splenic cell ratio J:308792
enlarged spleen J:308792
normal hematopoietic system phenotype J:308792
increased germinal center B cell number J:308792
increased IgM level J:308792
increased plasma cell number J:308792
Cd19tm1(cre)Cgn/Cd19+
Myd88em1.1Rsky/Myd88em1.1Rsky
involves: C57BL/6NTac 		increased B cell proliferation J:308792
Cd19tm1(cre/ERT2)Rsky/Cd19+
Myd88em1.1Rsky/Myd88+
involves: 129P2/OlaHsd * C57BL/6NTac 		increased IgM level J:308792
increased plasma cell number J:308792
Ighg1tm1(cre)Cgn/Ighg1+
Myd88em1.1Rsky/Myd88+
involves: 129P2/OlaHsd * C57BL/6NTac 		abnormal somatic hypermutation frequency J:308792
abnormal splenic cell ratio J:308792
normal hematopoietic system phenotype J:308792
increased germinal center B cell number J:308792
increased IgM level J:308792
increased plasma cell number J:308792
Myd88lkd/Myd88lkd
C57BL/6-Myd88lkd 		abnormal adaptive immunity J:110094
abnormal cell-mediated immunity J:110094
abnormal innate immunity J:110094
abnormal macrophage physiology J:110094
normal immune system phenotype J:110094
Myd88m3Btlr/Myd88m3Btlr
C57BL/6J-Myd88m3Btlr 		normal immune system phenotype J:156848
Myd88M4Btlr/Myd88+
C57BL/6J-Myd88M4Btlr 		decreased tumor necrosis factor secretion J:254917
Myd88M4Btlr/Myd88M4Btlr
C57BL/6J-Myd88M4Btlr 		decreased tumor necrosis factor secretion J:254917
Myd88poc/Myd88+
C57BL/6-Myd88poc 		normal immune system phenotype J:110094
Myd88poc/Myd88poc
C57BL/6-Myd88poc 		abnormal immune system physiology J:110094
abnormal macrophage physiology J:110094
normal immune system phenotype J:110094
increased susceptibility to bacterial infection J:110094
increased susceptibility to Herpesvirales infection J:110094
Myd88tm1.1Defr/Myd88tm1.1Defr
B6.129P2(SJL)-Myd88tm1.1Defr 		abnormal CD4-positive, alpha-beta T cell physiology J:224849
abnormal macrophage physiology J:224849
abnormal microglial cell physiology J:224849
decreased effector memory CD4-positive, alpha-beta T cell number J:224849
decreased interferon-gamma secretion J:224849
decreased leukocyte cell number J:224849
decreased macrophage cell number J:224849
decreased monocyte cell number J:224849
decreased neutrophil cell number J:224849
demyelination J:224849
increased susceptibility to Coronaviridae infection J:224849
increased susceptibility to Coronaviridae infection induced morbidity/mortality J:224849
paralysis J:224849
Myd88tm1.1Medz/Myd88tm1.1Medz
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:209373
Myd88tm1.1Medz/Myd88tm1.1Medz
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		abnormal CD4-positive, alpha-beta T cell physiology J:209373
abnormal memory T cell physiology J:209373
abnormal T-helper 1 physiology J:209373
abnormal T-helper 17 cell physiology J:209373
Myd88tm1.1Papr/Myd88tm1.1Papr
Not Specified 		normal reproductive system phenotype J:178967
Myd88tm1a(EUCOMM)Wtsi/Myd88tm1a(EUCOMM)Wtsi
C57BL/6N-Myd88tm1a(EUCOMM)Wtsi/Wtsi 		decreased mean corpuscular volume J:175295
increased body weight J:175295
Myd88tm1Aki/Myd88tm1Aki
B6.129-Myd88tm1Aki 		abnormal susceptibility to bacterial infection J:189854
decreased interleukin-6 secretion J:189854
decreased tumor necrosis factor secretion J:189854
Myd88tm1Aki/Myd88tm1Aki
B6.129P2-Myd88tm1Aki 		abnormal chemokine secretion J:102879
abnormal cytokine secretion J:116670, J:162707
abnormal dendritic cell differentiation J:139001
abnormal dendritic cell physiology J:116670, J:118954
abnormal enterocyte morphology J:128329
abnormal immune system physiology J:121070
abnormal innate immunity J:162707
abnormal macrophage physiology J:116670
abnormal nervous system physiology J:122826
abnormal neuron differentiation J:129957
abnormal NK cell physiology J:139001
abnormal response to infection J:121070
abnormal susceptibility to hearing loss J:123946
abnormal T cell physiology J:97662
bronchiolitis J:162707
decreased inflammatory response J:123946
decreased interferon-alpha secretion J:97662
decreased interferon-gamma secretion J:116763, J:118954
decreased interleukin-6 secretion J:118954, J:121070
decreased interleukin-12 secretion J:116670
decreased interleukin-12b secretion J:116763, J:118954
decreased susceptibility to kidney reperfusion injury J:146120
decreased susceptibility to parasitic infection J:116763
decreased tumor necrosis factor secretion J:116670, J:116763, J:121070
increased apoptosis J:102879
increased dendritic cell number J:116763
increased physiological sensitivity to xenobiotic J:102879
increased susceptibility to Coronaviridae infection J:162707
increased susceptibility to Coronaviridae infection induced morbidity/mortality J:162707
increased susceptibility to Picornaviridae infection J:97662
rectal hemorrhage J:128329
Myd88tm1Aki/Myd88tm1Aki
C.129P2-Myd88tm1Aki 		decreased susceptibility to induced arthritis J:178054
Myd88tm1Aki/Myd88tm1Aki
involves: 129P2/OlaHsd 		abnormal airway responsiveness J:147534
abnormal cytokine level J:174941
abnormal cytokine secretion J:167340
abnormal dendritic cell physiology J:137522, J:174941
abnormal enterocyte physiology J:167340
abnormal glucose homeostasis J:124334
abnormal gut flora balance J:177506
abnormal interferon level J:137522
abnormal macrophage physiology J:174941
abnormal neutrophil physiology J:145345
abnormal pancreatic beta cell morphology J:148283
abnormal pancreatic beta cell physiology J:148283
abnormal respiratory system physiology J:147534
abnormal retina progenitor cell morphology J:141070
abnormal tumor necrosis factor level J:103464, J:124334
decreased circulating tumor necrosis factor level J:139030
decreased interferon-alpha secretion J:144400
decreased interferon-gamma secretion J:210086
decreased interleukin-6 secretion J:167340
decreased liver tumor incidence J:103464
decreased pancreatic beta cell mass J:148283
decreased susceptibility to experimental autoimmune encephalomyelitis J:105435
normal digestive/alimentary phenotype J:177506
normal hematopoietic system phenotype J:135830
hyperglycemia J:148283
increased IgA level J:210086
increased IgE level J:115059
increased IgG1 level J:115059
increased susceptibility to bacterial infection J:210086
increased susceptibility to induced colitis J:167340
increased susceptibility to Picornaviridae infection J:137522
small pancreatic islets J:148283
Myd88tm1Aki/Myd88tm1Aki
involves: 129P2/OlaHsd * C57BL/6 		abnormal chemokine secretion J:141143
abnormal cytokine secretion J:117688
abnormal dendritic cell physiology J:122394
abnormal macrophage physiology J:117688, J:141143
decreased IgG2b level J:137066
decreased IgG3 level J:137066
decreased IgG level J:137066
decreased incidence of tumors by chemical induction J:162097
decreased interleukin-1 beta secretion J:124226
decreased interleukin-6 secretion J:147023
normal immune system phenotype J:132662
Myd88tm1Aki/Myd88tm1Aki
Not Specified 		abnormal cytokine secretion J:88906, J:89257
abnormal dendritic cell physiology J:96773
abnormal macrophage physiology J:96773
abnormal NK cell physiology J:88906
abnormal NK T cell physiology J:88906
abnormal T cell physiology J:96773
decreased B cell proliferation J:96773
increased susceptibility to Herpesvirales infection J:88906
Myd88tm1Aki/Myd88tm1Aki
Tg(Vil-Myd88)#Lvh/0
involves: 129P2/OlaHsd 		normal digestive/alimentary phenotype J:177506
Myd88tm1Defr/Myd88tm1Defr
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal NK cell physiology J:139001
Myd88tm1Defr/Myd88tm1Defr
Tg(Itgax-cre)1-1Reiz/0
B6.Cg-Myd88tm1Defr Tg(Itgax-cre)1-1Reiz 		abnormal dendritic cell antigen presentation J:139001
abnormal dendritic cell differentiation J:139001
abnormal dendritic cell physiology J:139001
abnormal NK cell physiology J:139001
abnormal T-helper 1 cell differentiation J:139001
decreased circulating interleukin-6 level J:139001
decreased circulating interleukin-12b level J:139001
decreased IgG1 level J:139001
decreased IgG2b level J:139001
decreased IgG2c level J:139001
Myd88tm1Defr/Myd88tm1Defr
Tg(Vil1-cre)997Gum/0
involves: 129P2/OlaHsd * C57BL/6J * SJL 		abnormal gut flora balance J:177506
Myd88tm1Hlz/Myd88tm1Hlz
B6.129P2-Myd88tm1Hlz 		abnormal chemokine level J:188968
decreased circulating alanine transaminase level J:188968
decreased circulating aspartate transaminase level J:188968
decreased circulating interleukin-6 level J:188968
decreased circulating interleukin-10 level J:188968
decreased circulating interleukin-12b level J:188968
decreased interleukin-6 secretion J:188968
decreased interleukin-10 secretion J:188968
decreased neutrophil cell number J:188968
decreased tumor necrosis factor secretion J:188968
Myd88tm1Hlz/Myd88tm1Hlz
Lyz2tm1(cre)Ifo/Lyz2+
B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo 		abnormal circulating chemokine level J:188968
decreased CXCL10 level J:188968
normal immune system phenotype J:188968
increased circulating alanine transaminase level J:188968
increased circulating aspartate transaminase level J:188968
increased circulating tumor necrosis factor level J:188968
increased susceptibility to injury J:188968
Myd88tm1Jcbr/Myd88tm1Jcbr
Tg(Nes-cre)1Kln/0
B6.Cg-Myd88tm1Jcbr Tg(Nes-cre)1Kln 		abnormal glucose homeostasis J:153664
abnormal parametrial fat pad morphology J:153664
decreased body length J:153664
decreased circulating insulin level J:153664
decreased epididymal fat pad weight J:153664
decreased fat cell size J:153664
decreased food intake J:153664
decreased locomotor activity J:153664
decreased susceptibility to diet-induced obesity J:153664
decreased total body fat amount J:153664
increased energy expenditure J:153664
increased insulin sensitivity J:153664
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory