About   Help   FAQ
Chemically induced Allele Detail
Symbol: Myd88lkd
Name: myeloid differentiation primary response gene 88; lackadaisical
MGI ID: MGI:3641234
Synonyms: Lkd, Myd88m1Btlr
Gene: Myd88  Location: Chr9:119165000-119169084 bp, - strand  Genetic Position: Chr9, 71.33 cM
Alliance: Myd88lkd page
Strain of Origin:  C57BL/6
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThis mutation, identified in a screen of G3 progeny of ENU treated mice for responses to various toll-like receptor ligands, is an A-to-G transition resulting in replacement of tyrosine with cysteine at amino acid 116 (Y116C), between the death domain (aa 19-109) and the toll-interleukin 1 receptor (TIR) domain (aa 160-296) of the protein. (J:86521, J:110094)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myd88 Mutation:  44 strains or lines available
Genbank ID for this allele: DQ790886
Original:  J:110094 Jiang Z, et al., Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10961-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory