Cd19^{tm1(cre/ERT2)Rsky}
Targeted Allele Detail

Summary

• Symbol: Cd19^{tm1(cre/ERT2)Rsky}
• Name: CD19 antigen; targeted mutation 1, Klaus Rajewsky
• MGI ID: MGI:5614310
• Synonyms: CD19^-, CD19creERT2, CD19-CreER^T2
• Gene: Cd19 Location: Chr7:126007622-126014061 bp, - strand Genetic Position: Chr7, 69.01 cM, cytoband F3-F4
• Alliance: Cd19^{tm1(cre/ERT2)Rsky} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217520
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Cd19^{tm1(cre/ERT2)Rsky} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd19 (MGI:88319)

• The cre/ERT2 fusion gene was knocked into exon 2. (J:217520)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd19 (mouse) Summary of all recombinase alleles driven by Cd19. Alliance mouse Cd19 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd19 Mutation: 56 strains or lines available

References

• Original: J:217520 Yasuda T, et al., Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice. Cold Spring Harb Symp Quant Biol. 2013;78:259-63
• All: 9 reference(s)