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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Amhr2
anti-Mullerian hormone type 2 receptor
MGI:105062
165 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Amhtm1Bhr/Amh+
Amhr2tm1Bhr/Amhr2tm1Bhr
involves: 129S7/SvEvBrd * C57BL/6 		increased testis tumor incidence J:36027
male pseudohermaphroditism J:36027
secondary sex reversal J:36027
Amhtm1Bhr/Amhtm1Bhr
Amhr2tm1Bhr/Amhr2tm1Bhr
Not Specified 		male infertility J:36027
male pseudohermaphroditism J:36027
normal reproductive system phenotype J:36027
secondary sex reversal J:36027
Amhr2tm1Bhr/Amhr2tm1Bhr
Inhatm1Bay/Inha+
involves: 129S7/SvEvBrd * C57BL/6 		increased testis tumor incidence J:36027
male pseudohermaphroditism J:36027
secondary sex reversal J:36027
Amhr2tm1Bhr/Amhr2tm1Bhr
Inhatm1Bay/Inhatm1Bay
involves: 129S7/SvEvBrd 		dilated uterus J:36027
increased granulosa cell tumor incidence J:36027
increased Leydig cell tumor incidence J:36027
increased testis tumor incidence J:36027
increased tumor incidence J:36027
male pseudohermaphroditism J:36027
secondary sex reversal J:36027
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S/SvEv * C57BL/6 		early reproductive senescence J:128934
hemoperitoneum J:128934
increased ovarian carcinoma incidence J:128934
increased ovary tumor incidence J:128934
increased testis tumor incidence J:128934
male infertility J:128934
Amhr2tm3(cre)Bhr/Amhr2+
KitW-v/KitW-v
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/N 		increased granulosa cell tumor incidence J:236161
increased ovary adenoma incidence J:236161
increased ovary tumor incidence J:236161
Amhr2tm3(cre)Bhr/Amhr2+
Nr5a1tm1Klp/Nr5a1tm2Klp
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		abnormal endometrial gland development J:145805
abnormal endometrial gland morphology J:145805
abnormal estrous cycle J:145805
abnormal ovarian follicle number J:91352, J:145805
abnormal ovary physiology J:145805
abnormal ovulation J:91352
abnormal seminiferous tubule morphology J:91352
abnormal testis cord formation J:91352
abnormal testis development J:91352
abnormal uterus morphology J:145805
absent corpus luteum J:91352, J:145805
absent estrous cycle J:145805
absent sexual maturation J:91352
arrest of spermatogenesis J:91352
cryptorchism J:91352
decreased circulating estradiol level J:145805
decreased circulating testosterone level J:91352
decreased endometrial gland number J:145805
decreased granulosa cell proliferation J:145805
decreased ovary weight J:145805
decreased primary ovarian follicle number J:145805
decreased primordial ovarian follicle number J:145805
decreased secondary ovarian follicle number J:145805
decreased superovulation rate J:145805
decreased tertiary ovarian follicle number J:145805
decreased uterus weight J:145805
female infertility J:91352, J:145805
impaired ovarian folliculogenesis J:145805
increased circulating follicle stimulating hormone level J:145805
internal male genitalia hypoplasia J:91352
male infertility J:91352
ovarian follicular cyst J:91352
ovary hemorrhage J:91352
ovary hypoplasia J:91352, J:145805
prolonged estrous cycle J:145805
short estrus J:145805
small adrenal glands J:91352
small testis J:91352
testis hypoplasia J:91352
thin myometrium J:145805
Amhr2tm3(cre)Bhr/Amhr2+
Wnt4tm1Amc/Wnt4tm1.1Bhr
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J 		normal reproductive system phenotype J:171430
Amhr2tm3(cre)Bhr/Amhr2+
Fsttm1Zuk/Fsttm2Zuk
involves: 129S/SvEv * C57BL/6J 		abnormal ovary morphology J:89081
decreased circulating testosterone level J:89081
decreased corpora lutea number J:89081
decreased litter size J:89081
decreased superovulation rate J:89081
decreased tertiary ovarian follicle number J:89081
female infertility J:89081
normal homeostasis/metabolism phenotype J:89081
impaired fertilization J:89081
increased circulating follicle stimulating hormone level J:89081
increased circulating luteinizing hormone level J:89081
ovary cyst J:89081
ovary hemorrhage J:89081
reduced female fertility J:89081
normal reproductive system phenotype J:89081
Amhr2tm3(cre)Bhr/Amhr2+
Smad3tm1Par/Smad3tm1Zuk
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 		normal reproductive system phenotype J:142827
Amhr2tm3(cre)Bhr/Amhr2+
Smad2tm1Cxd/Smad2tm1.1Mwst
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		normal reproductive system phenotype J:142827
Amhr2tm3(cre)Bhr/Amhr2+
Smad2tm1Cxd/Smad2tm1.1Mwst
Smad3tm1Par/Smad3tm1Zuk
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cumulus expansion J:142827
abnormal ovarian follicle morphology J:142827
decreased litter size J:142827
decreased oocyte number J:142827
decreased tertiary ovarian follicle number J:142827
increased atretic ovarian follicle number J:142827
increased circulating follicle stimulating hormone level J:142827
increased circulating luteinizing hormone level J:142827
premature ovarian failure J:142827
reduced female fertility J:142827
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		increased granulosa cell tumor incidence J:186144
increased testis tumor incidence J:186144
male infertility J:186144
seminiferous tubule degeneration J:186144
testicular atrophy J:186144
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ 		anemia J:142150
decreased hematocrit J:142150
extramedullary hematopoiesis J:142150
increased granulosa cell tumor incidence J:149060
increased metastatic potential J:142150, J:149060
increased ovary tumor incidence J:142150
increased testis tumor incidence J:149060
premature death J:142150
pulmonary embolism J:142150
seminiferous tubule degeneration J:149060
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		increased granulosa cell tumor incidence J:186144
increased testis tumor incidence J:186144
Amhr2tm3(cre)Bhr/Amhr2+
Inhbatm1Zuk/Inhbatm3Zuk
involves: 129S7/SvEvBrd * C57BL/6J 		decreased litter size J:125354
increased corpora lutea number J:125354
polyovular ovarian follicle J:125354
reduced female fertility J:125354
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		abnormal Mullerian duct morphology J:171430
abnormal sex determination J:171430
failure of Mullerian duct regression J:171430
Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2.1Rob
Smad5tm1Huy/Smad5tm1Huy
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		early reproductive senescence J:128934
hemoperitoneum J:128934
increased ovarian carcinoma incidence J:128934
increased ovary tumor incidence J:128934
increased testis tumor incidence J:128934
male infertility J:128934
Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2.1Rob
Smad5tm1Huy/Smad5tm1Huy
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		increased granulosa cell tumor incidence J:157310
premature death J:157310
suppressed circulating follicle stimulating hormone level J:157310
Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Huy
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		increased granulosa cell tumor incidence J:157310
premature death J:157310
suppressed circulating follicle stimulating hormone level J:157310
Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Zuk
involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6 		early reproductive senescence J:128934
hemoperitoneum J:128934
increased ovarian carcinoma incidence J:128934
increased ovary tumor incidence J:128934
increased testis tumor incidence J:128934
male infertility J:128934
Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Zuk
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		increased granulosa cell tumor incidence J:157310
premature death J:157310
suppressed circulating follicle stimulating hormone level J:157310
Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Zuk
Smad9tm1Jfm/Smad9tm1Jfm
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 		early reproductive senescence J:128934
hemoperitoneum J:128934
increased ovarian carcinoma incidence J:128934
increased ovary tumor incidence J:128934
Amhr2tm3(cre)Bhr/Amhr2+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		abnormal endometrium morphology J:170203
abnormal maternal decidual layer morphology J:170203
abnormal myometrium morphology J:170203
abnormal placenta labyrinth morphology J:170203
abnormal placenta vasculature J:170203
abnormal trophoblast layer morphology J:170203
decreased litter size J:170203
decreased uterine NK cell number J:170203
endometrium fibrosis J:170203
endometrium hyperplasia J:170203
reduced female fertility J:170203
normal reproductive system phenotype J:187754
uterus hyperplasia J:170203
Amhr2tm3(cre)Bhr/Amhr2+
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
involves: 129S7/SvEvBrd * C57BL/6 		male pseudohermaphroditism J:89999
secondary sex reversal J:89999
Amhr2tm3(cre)Bhr/Amhr2+
Stk11tm1Rdp/Stk11tm1Rdp
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal seminiferous tubule epithelium morphology J:187754
abnormal seminiferous tubule morphology J:187754
abnormal Sertoli cell morphology J:187754
abnormal spermatogenesis J:187754
abnormal testis morphology J:187754
decreased male germ cell number J:187754
decreased testis weight J:187754
increased Sertoli cell proliferation J:187754
normal neoplasm J:187754
small testis J:187754
Amhr2tm3(cre)Bhr/Amhr2+
Artm1Chc/Y
involves: 129S/SvEv * C57BL/6 		abnormal meiosis J:118270
abnormal seminiferous tubule morphology J:118270
arrest of male meiosis J:118270
arrest of spermatogenesis J:118270
azoospermia J:118270
decreased circulating testosterone level J:118270
male infertility J:118270
small seminiferous tubules J:118270
small testis J:118270
Amhr2tm3(cre)Bhr/Amhr2+
Tsc1tm1Djk/Tsc1tm1Djk
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		abnormal myometrium morphology J:181774
abnormal oocyte morphology J:181774
abnormal ovary physiology J:181774
abnormal oviduct morphology J:181774
abnormal preimplantation embryo development J:181774
abnormal seminiferous tubule epithelium morphology J:187754
abnormal seminiferous tubule morphology J:187754
abnormal Sertoli cell morphology J:187754
abnormal spermatogenesis J:187754
abnormal testis morphology J:187754
decreased male germ cell number J:187754
decreased primordial ovarian follicle number J:181774
decreased testis weight J:187754
dilated oviduct J:181774
endometrium hyperplasia J:181774
failure of embryo implantation J:181774
female infertility J:181774
impaired ovarian folliculogenesis J:181774
increased atretic ovarian follicle number J:181774
increased Sertoli cell proliferation J:187754
normal neoplasm J:181774, J:187754
oocyte degeneration J:181774
premature ovarian failure J:181774
prolonged estrus J:181774
normal reproductive system phenotype J:181774
short diestrus J:181774
small testis J:187754
Amhr2tm3(cre)Bhr/Amhr2+
Trp53tm2Tyj/Trp53+
involves: 129S4/SvJae * 129S7/SvEvBrd 		normal neoplasm J:222579
Amhr2tm3(cre)Bhr/Amhr2+
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
involves: 129S7/SvEvBrd 		abnormal maternal decidual layer morphology J:120852
abnormal myometrium morphology J:120852
abnormal placenta development J:120852
abnormal placental labyrinth vasculature morphology J:120852
abnormal uterine environment J:120852
absent placental labyrinth J:120852
decreased spongiotrophoblast cell number J:120852
edema J:120852
embryonic lethality, incomplete penetrance J:120852
hemorrhage J:120852
impaired embryo implantation J:120852
increased miscarriage rate J:120852
increased trophoblast giant cell number J:120852
reduced female fertility J:120852
short uterine horn J:120852
vaginal hemorrhage J:120852
Amhr2tm3(cre)Bhr/Amhr2+
Smad4tm1Rob/Smad4tm1.1Rob
involves: 129S/SvEv * C57BL/6J 		abnormal cumulus expansion J:108954
abnormal granulosa cell morphology J:108954
abnormal ovarian follicle morphology J:108954
abnormal ovarian folliculogenesis J:108954
abnormal secondary ovarian follicle morphology J:108954
absent cumulus expansion J:108954
decreased litter size J:108954
decreased oocyte number J:108954
decreased ovulation rate J:108954
decreased tertiary ovarian follicle number J:108954
increased circulating progesterone level J:108954
increased secondary ovarian follicle number J:108954
infertility J:108954
Amhr2tm3(cre)Bhr/Amhr2+
Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		abnormal seminiferous tubule epithelium morphology J:187754
abnormal seminiferous tubule morphology J:187754
abnormal Sertoli cell morphology J:187754
abnormal spermatogenesis J:187754
abnormal testis morphology J:187754
decreased male germ cell number J:187754
decreased testis weight J:187754
increased Sertoli cell proliferation J:187754
normal neoplasm J:187754
small testis J:187754
Amhr2tm3(cre)Bhr/Amhr2+
Ptprvtm1Kry/Ptprvtm1Kry
involves: 129S/SvEv 		normal reproductive system phenotype J:170888
Amhr2tm3(cre)Bhr/Amhr2+
Wnt4tm1.1Boer/Wnt4tm1.2Boer
involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ 		abnormal kidney development J:162337
abnormal ovary development J:162337
decreased litter size J:162337
decreased mature ovarian follicle number J:162337
decreased ovary weight J:162337
decreased renal glomerulus number J:162337
disheveled coat J:162337
postnatal growth retardation J:162337
premature death J:162337
Ctnnb1tm1Mmt/Ctnnb1+
Krastm4Tyj/Kras+
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		increased granulosa cell tumor incidence J:186144
increased testis tumor incidence J:186144
seminiferous tubule degeneration J:186144
Dicer1tm1Bdh/Dicer1tm1Bdh
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129 		abnormal oviduct morphology J:142113
abnormal oviduct transport J:142113
abnormal pregnancy J:142113
abnormal uterus morphology J:142113
decreased circulating progesterone level J:142113
decreased endometrial gland number J:142113
decreased ovary weight J:142113
decreased ovulation rate J:142113
decreased superovulation rate J:142113
decreased uterus weight J:142113
failure of embryo implantation J:142113
female infertility J:142113
normal homeostasis/metabolism phenotype J:142113
normal reproductive system phenotype J:142113
short oviduct J:142113
short uterine horn J:142113
small uterus J:142113
thin myometrium J:142113
Dicer1tm1Tara/Dicer1tm1Tara
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		normal neoplasm J:222579
Dicer1tm1Tara/Dicer1tm1Tara
Ptentm1Hwu/Ptentm1Hwu
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd 		abnormal oviduct morphology J:182161
ascites J:182161
increased carcinoma incidence J:182161
increased metastatic potential J:182161
increased ovarian carcinoma incidence J:182161
premature death J:182161
Dicer1tm1Tara/Dicer1tm1Tara
Ptentm1Hwu/Ptentm1Hwu
Trp53tm2Tyj/Trp53+
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd 		ascites J:222579
increased carcinoma incidence J:222579
increased metastatic potential J:222579
increased ovarian carcinoma incidence J:222579
premature death J:222579
Dicer1tm1Tara/Dicer1tm1Tara
Trp53tm2Tyj/Trp53+
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd 		normal neoplasm J:222579
Foxl2tm1.1Rthi/Foxl2+
Amhr2tm3(cre)Bhr/Amhr2+
B6.Cg-Foxl2tm1.1Rthi Amhr2tm3(cre)Bhr 		increased granulosa cell tumor incidence J:369668
ovary cyst J:369668
prenatal lethality, incomplete penetrance J:369668
Foxo1tm1Rdp/Foxo1tm1.1Rdp
Foxo3tm1Rdp/Foxo3tm1.1Rdp
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal circulating hormone level J:232961
abnormal ovarian follicle morphology J:232961
decreased circulating luteinizing hormone level J:232961
hemorrhagic ovary cyst J:232961
increased circulating estradiol level J:232961
increased granulosa cell tumor incidence J:232961
ovary cyst J:232961
suppressed circulating follicle stimulating hormone level J:232961
Gata4tm1.1Sad/Gata4tm1.1Sad
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J 		abnormal ovary physiology J:173711
abnormal seminiferous tubule epithelium morphology J:169018
abnormal Sertoli cell barrier function J:169018
abnormal Sertoli cell morphology J:169018
abnormal spermatogenesis J:169018
asthenozoospermia J:169018
decreased circulating anti-Mullerian hormone level J:173711
decreased elongated spermatid number J:169018
decreased litter size J:173711
decreased male germ cell number J:169018
decreased sperm progressive motility J:169018
decreased superovulation rate J:173711
decreased testis weight J:169018
failure of superovulation J:173711
female infertility J:173711
normal homeostasis/metabolism phenotype J:169018
increased male germ cell apoptosis J:169018
multinucleated giant male germ cells J:169018
oligozoospermia J:169018
ovarian follicular cyst J:173711
ovary cyst J:173711
reduced female fertility J:173711
reduced male fertility J:169018
normal reproductive system phenotype J:169018, J:173711
seminiferous tubule degeneration J:169018
small ovary J:173711
small testis J:169018
testicular atrophy J:169018
Inhbatm1Zuk/Inhbatm3Zuk
Inhbbtm1Jae/Inhbbtm1Jae
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J 		abnormal ovarian follicle morphology J:125354
abnormal tertiary ovarian follicle morphology J:125354
absent oocytes J:125354
female infertility J:125354
increased corpora lutea number J:125354
increased follicle stimulating hormone level J:125354
increased ovary weight J:125354
ovarian follicular cyst J:125354
Kat8tm1Thl/Kat8tm1Thl
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		normal reproductive system phenotype J:242000
Kmt2btm1Afst/Kmt2btm1.1Afst
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		abnormal DNA methylation J:166778
abnormal ovarian follicle number J:166778
decreased primary ovarian follicle number J:166778
decreased primordial ovarian follicle number J:166778
decreased secondary ovarian follicle number J:166778
increased atretic ovarian follicle number J:166778
increased circulating follicle stimulating hormone level J:166778
reduced female fertility J:166778
Ptentm1Hwu/Ptentm1Hwu
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S4/SvJae * 129S7/SvEvBrd 		abnormal pregnancy J:142150
decreased litter size J:142150
increased granulosa cell tumor incidence J:142150, J:222579
increased metastatic potential J:142150
normal reproductive system phenotype J:142150
Ptentm1Hwu/Ptentm1Hwu
Trp53tm2Tyj/Trp53+
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd 		ascites J:222579
increased granulosa cell tumor incidence J:222579
increased metastatic potential J:222579
increased ovarian carcinoma incidence J:222579
premature death J:222579
Tspotm1.1Wbd/Tspotm1.1Wbd
Amhr2tm3(cre)Bhr/Amhr2+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 		normal reproductive system phenotype J:207708
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12/30/2025
MGI 6.24 		The Jackson Laboratory