Fst^tm2Zuk
Targeted Allele Detail

Summary

• Symbol: Fst^tm2Zuk
• Name: follistatin; targeted mutation 2, Martin M Matzuk
• MGI ID: MGI:3040645
• Synonyms: Fst^Flox
• Gene: Fst Location: Chr13:114588826-114595487 bp, - strand Genetic Position: Chr13, 64.15 cM
• Alliance: Fst^tm2Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89081
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2-6 were flanked by LoxP sites, with a neo cassette inserted between exon 6 and the 3' LoxP sequence. Southern blot confirmed successful recombination. (J:89081)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fst Mutation: 18 strains or lines available

References

• Original: J:89081 Jorgez CJ, et al., Granulosa cell-specific inactivation of follistatin causes female fertility defects. Mol Endocrinol. 2004 Apr;18(4):953-67
• All: 10 reference(s)