Foxl2^tm1.1Rthi
Targeted Allele Detail

Summary

• Symbol: Foxl2^tm1.1Rthi
• Name: forkhead box L2; targeted mutation 1.1, R Tyler Hillman
• MGI ID: MGI:8250561
• Synonyms: Foxl2^C130W-FLEx
• Gene: Foxl2 Location: Chr9:98837495-98840601 bp, + strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Foxl2^tm1.1Rthi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:369668
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: The endogenous Foxl2 was replaced with a FLEx cassette consisting of a lox2272 site, FRT-flanked PGK-neomcyin cassette, loxP site, an inverted Foxl2 containing a C to G change which results in a cysteine to tryptophan substitution at amino acid 130 (p.C130W), lox2272 site and loxP site. The neomycin cassette was removed via flp-mediated recombination resulting in an inducible Foxl2 mutant FLEx allele. This mutation corresponds to the ovarian sex cord/stromal tumor hotspot mutation p.C134W in humans. (J:369668)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxl2 Mutation: 16 strains or lines available

References

• Original: J:369668 Li J, et al., An inducible FOXL2-dependent mouse model of ovarian adult type granulosa cell tumor. Gynecol Oncol. 2025 Mar;194:125-130
• All: 1 reference(s)