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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxl2tm1.1Rthi
targeted mutation 1.1, R Tyler Hillman
MGI:8250561
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Foxl2tm1.1Rthi/Foxl2+
Amhr2tm3(cre)Bhr/Amhr2+
B6.Cg-Foxl2tm1.1Rthi Amhr2tm3(cre)Bhr MGI:8250567


Genotype
MGI:8250567
cn1
Allelic
Composition
Foxl2tm1.1Rthi/Foxl2+
Amhr2tm3(cre)Bhr/Amhr2+
Genetic
Background
B6.Cg-Foxl2tm1.1Rthi Amhr2tm3(cre)Bhr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (24 available)
Foxl2tm1.1Rthi mutation (0 available); any Foxl2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than the expected numbers of mice are obtained, with a sex imbalance favoring males, with only 8% of progeny being females
• females develop normally into adulthood

neoplasm
• by 12-14 months of age, some females develop unilateral ovarian adult-type granulosa cell tumors ranging from microscopic to grossly visible tumors

endocrine/exocrine glands
• by 12-14 months of age, some females develop unilateral ovarian adult-type granulosa cell tumors ranging from microscopic to grossly visible tumors
• females begin to develop cystic uterine changes around 9-10 months of age such that by 10 months of age, all females showed extensive cystic uterine changes

growth/size/body
• females begin to develop cystic uterine changes around 9-10 months of age such that by 10 months of age, all females showed extensive cystic uterine changes

reproductive system
• by 12-14 months of age, some females develop unilateral ovarian adult-type granulosa cell tumors ranging from microscopic to grossly visible tumors
• females begin to develop cystic uterine changes around 9-10 months of age such that by 10 months of age, all females showed extensive cystic uterine changes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
granulosa cell tumor DOID:2999 J:369668





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/30/2025
MGI 6.24
The Jackson Laboratory