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Nr5a1tm1Klp
Targeted Allele Detail
Summary
Symbol: Nr5a1tm1Klp
Name: nuclear receptor subfamily 5, group A, member 1; targeted mutation 1, Keith L Parker
MGI ID: MGI:1857391
Synonyms: Ftz-F1, Ftz-F1-, Ftzf1tm1Klp, Sf-, sf-1-, Sf1-, SF-1
Gene: Nr5a1  Location: Chr2:38582668-38604554 bp, - strand  Genetic Position: Chr2, 24.42 cM
Alliance: Nr5a1tm1Klp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:35576
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into exon 4, which disrupted sequences encoding the second zinc finger of the DNA binding domain. (J:35576)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 154 assay results
In Structures Affected by this Mutation: 21 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr5a1 Mutation:  30 strains or lines available
References
Original:  J:35576 Luo X, et al., A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell. 1994 May 20;77(4):481-90
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory