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Targeted Allele Detail
Symbol: Smad2tm1Cxd
Name: SMAD family member 2; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:1857694
Synonyms: smad2deltaC
Gene: Smad2  Location: Chr18:76374651-76444034 bp, + strand  Genetic Position: Chr18, 51.42 cM
Alliance: Smad2tm1Cxd page
Morphological analysis of the Smad2tm1Cxd/Smad2tm1Cxd embryo

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:49084
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette replaced 2.5 kb of the gene, including the sequence that encodes the carboxy-terminal 86 amino acids of the protein. Southern blots and PCR analysis indicated that the mutation was passed on to the agouti offspring of the chimeras. (J:49084)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 11 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad2 Mutation:  50 strains or lines available
Original:  J:49084 Weinstein M, et al., Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9378-83
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory