Smad2^tm1Cxd
Targeted Allele Detail

Summary

• Symbol: Smad2^tm1Cxd
• Name: SMAD family member 2; targeted mutation 1, Chu-Xia Deng
• MGI ID: MGI:1857694
• Synonyms: smad2^deltaC
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm1Cxd page

Morphological analysis of the Smad2^tm1Cxd/Smad2^tm1Cxd embryo

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49084
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced 2.5 kb of the gene, including the sequence that encodes the carboxy-terminal 86 amino acids of the protein. Southern blots and PCR analysis indicated that the mutation was passed on to the agouti offspring of the chimeras. (J:49084)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 50 strains or lines available

References

• Original: J:49084 Weinstein M, et al., Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9378-83
• All: 10 reference(s)