About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
MGI:104556
167 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Apoetm1Unc/Apoetm1Unc
Cdkn1atm1Tyj/Cdkn1atm1Tyj
B6.129-Apoetm1Unc Cdkn1atm1Tyj
abnormal response/metabolism to endogenous compounds J:125247
abnormal vascular smooth muscle physiology J:125247
decreased sensitivity to induced morbidity/mortality J:125247
decreased susceptibility to atherosclerosis J:125247
delayed cellular replicative senescence J:125247
Brca1tm1Mak/Brca1tm1Mak
Cdkn1atm1Tyj/Cdkn1atm1Tyj
involves: 129P2/OlaHsd * 129S2/SvPas
embryonic lethality during organogenesis, complete penetrance J:41254
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Cdkn1atm1Led/Cdkn1atm1Led
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB
neonatal lethality, complete penetrance J:81559
Brca1tm2Mak/Brca1tm2Mak
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Tg(Lck-cre)548Jxm/?
involves: 129P2/OlaHsd * C57BL/6 * CBA
decreased thymocyte number J:63282
normal immune system phenotype J:63282
Ccne1tm1Jro/?
Cdkn1atm1Led/Cdkn1atm1Led
either: (involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J) or (involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6J)
abnormal cell morphology J:99695
chromosome breakage J:99695
decreased fibroblast proliferation J:99695
Cdkn1atm1Hpw/Cdkn1a+
Trp53tm2Wahl/Trp53tm2Wahl
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
decreased mortality induced by ionizing radiation J:174375
Cdkn1atm1Led/Cdkn1atm1Led
Cdkn1ctm1Sje/Cdkn1c+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
abnormal axial skeleton morphology J:52552
abnormal bronchiole morphology J:52552
abnormal bronchus morphology J:52552
abnormal ileum morphology J:52552
abnormal jejunum morphology J:52552
abnormal kidney medulla development J:52552
abnormal lens development J:52552
abnormal lens epithelium morphology J:52552
abnormal limb bone morphology J:52552
abnormal long bone epiphysis morphology J:52552
abnormal pulmonary alveolus morphology J:52552
abnormal rib morphology J:52552
abnormal spine curvature J:52552
abnormal sternocostal joint morphology J:52552
abnormal sternum morphology J:52552
cleft palate J:52552
decreased fetal size J:52552
decreased skeletal muscle mass J:52552
herniated abdominal wall J:52552
increased skeletal muscle fiber size J:52552
lethality throughout fetal growth and development, incomplete penetrance J:52552
omphalocele J:52552
perinatal lethality, complete penetrance J:52552
postnatal lethality J:52552
respiratory distress J:52552
rib bifurcation J:52552
short sternum J:52552
small inner medullary pyramid J:52552
split sternum J:52552
thin diaphragm muscle J:52552
Cdkn1atm1Led/Cdkn1atm1Led
Cdkn1ctm2.1Kei/Cdkn1c+
Tg(Mx1-cre)1Cgn/0
B6.Cg-Cdkn1ctm2.1Kei Cdkn1atm1Led Tg(Mx1-cre)1Cgn
abnormal hematopoietic stem cell physiology J:176209
Cdkn1atm1Led/Cdkn1atm1Led
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0
involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N
increased urinary bladder carcinoma incidence J:234236
premature death J:234236
Cdkn1atm1Led/Cdkn1atm1Led
Fgfr3tm1Cxd/Fgfr3tm1Cxd
involves: 129S6/SvEvTac * NIH Black Swiss
abnormal long bone epiphyseal plate morphology J:52438
abnormal skeleton morphology J:52438
disproportionate dwarf J:52438
Cdkn1atm1Led/Cdkn1atm1Led
Gadd45atm1Ajf/Gadd45atm1Ajf
either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)
abnormal chromosome number J:57882
abnormal glomerular capillary endothelium morphology J:76041
abnormal lymphopoiesis J:76041
abnormal T cell activation J:76041
decreased basophil cell number J:76041
decreased eosinophil cell number J:76041
decreased leukocyte cell number J:76041
decreased lymphocyte cell number J:76041
dilated proximal convoluted tubules J:76041
glomerulonephritis J:76041
increased anti-double stranded DNA antibody level J:76041
increased anti-histone antibody level J:76041
increased anti-single stranded DNA antibody level J:76041
increased autoantibody level J:76041
increased fibroblast proliferation J:57882
increased IgG1 level J:76041
increased IgM level J:76041
increased inflammatory response J:76041
increased kidney cell proliferation J:76041
increased mesangial cell number J:76041
increased T cell proliferation J:76041
increased urine protein level J:76041
mesangial cell interposition J:76041
premature death J:76041
Cdkn1atm1Led/Cdkn1atm1Led
Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
abnormal mitosis J:197818
early cellular replicative senescence J:197818
Cdkn1atm1Led/Cdkn1atm1Led
Hus1tm1Led/Hus1tm1Led
involves: 129S6/SvEvTac
chromosome breakage J:63869
increased cellular sensitivity to hydroxyurea J:63869
increased cellular sensitivity to ultraviolet irradiation J:63869
Cdkn1atm1Led/Cdkn1atm1Led
Kdm8tm1.2Tasu/Kdm8tm1.2Tasu
involves: 129S4/SvJae * 129S6/SvEvTac * C3H * C57BL/6
absent vitelline blood vessels J:181189
embryonic growth retardation J:181189
embryonic lethality, complete penetrance J:181189
incomplete embryo turning J:181189
Cdkn1atm1Led/Cdkn1atm1Led
Wrntm1Led/Wrntm1Led
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * NIH Black Swiss)
increased tumor incidence J:68488
Cdkn1atm1Led/Cdkn1atm1Led
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio
arrested T cell differentiation J:170508
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Cdkn1btm1Ako/Cdkn1btm1Ako
involves: 129S1/Sv * 129S2/SvPas
abnormal junctional epithelium morphology J:102001
abnormal prostate gland anterior lobe morphology J:115443
abnormal prostate gland dorsolateral lobe morphology J:115443
abnormal prostate gland ventral lobe morphology J:115443
decreased circulating testosterone level J:115443
decreased prostate gland weight J:115443
decreased seminal vesicle weight J:115443
hepatic steatosis J:118516
impaired glucose tolerance J:118516
increased body weight J:115443, J:118516
increased brain weight J:118516
increased brown adipose tissue amount J:118516
increased circulating cholesterol level J:118516
increased food intake J:118516
increased inguinal fat pad weight J:118516
increased kidney weight J:118516
increased lean body mass J:118516
increased parametrial fat pad weight J:118516
increased total body fat amount J:118516
increased white fat cell number J:118516
insulin resistance J:118516
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Cdkn1btm1Mlf/Cdkn1btm1Mlf
involves: 129S2/SvPas * 129S4/SvJaeSor
abnormal crypts of Lieberkuhn morphology J:111081
abnormal enterocyte proliferation J:111081
abnormal ileum morphology J:111081
abnormal response to injury J:111081
abnormal small intestinal villus morphology J:111081
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Cdkn2atm1Rdp/Cdkn2atm1Rdp
involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
abnormal cell physiology J:72780
abnormal keratinocyte physiology J:72780
abnormal skin development J:72780
abnormal skin physiology J:72780
delayed cellular replicative senescence J:72780
increased keratinocyte proliferation J:72780
increased squamous cell carcinoma incidence J:72780
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Cdkn2dtm1Maro/Cdkn2dtm1Maro
involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1
abnormal cochlear hair cell physiology J:118337
abnormal cochlear inner hair cell morphology J:118337
decreased cochlear hair cell number J:118337
decreased cochlear inner hair cell number J:118337
decreased cochlear outer hair cell number J:118337
increased cochlear hair cell number J:118337
polyploidy J:118337
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn
Tg(Vil1-cre/ERT2)23Syr/0
involves: 129 * C57BL/6 * CD-1 * DBA/2
abnormal enterocyte proliferation J:204886
increased carcinoma incidence J:204886
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Fahtm1Mgo/Fahtm1Mgo
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
abnormal hepatocyte morphology J:138701
abnormal liver physiology J:138701
dilated proximal convoluted tubules J:138701
increased hepatocellular carcinoma incidence J:138701
increased hepatocyte apoptosis J:138701
increased hepatocyte proliferation J:138701
increased renal carcinoma incidence J:138701
kidney cyst J:138701
normal mortality/aging J:138701
weight loss J:138701
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Foxk1tm1Djg/Foxk1tm1Djg
involves: 129S2/SvPas * 129S4/SvJae
normal cellular phenotype J:81688
normal growth/size/body region phenotype J:81688
normal muscle phenotype J:81688
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Gadd45atm1Ajf/Gadd45atm1Ajf
either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ)
decreased cellular sensitivity to ultraviolet irradiation J:101710
normal homeostasis/metabolism phenotype J:101710
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Gata1tm1.1Yen/Gata1tm1.1Yen
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N
normal hematopoietic system phenotype J:200716
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Itgb1tm1Mll/Itgb1tm1Mll
Tg(Wap-cre)1Gsc/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N
abnormal mammary gland growth during lactation J:99405
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Mir34atm1.1Lhe/Mir34atm1.1Lhe
involves: 129S2/SvPas * C57BL/6 * C57BL/6J
abnormal cell physiology J:180692
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Palb2tm1.2Dli/Palb2tm1.2Dli
involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6
abnormal embryo development J:197442
fetal growth retardation J:197442
lethality throughout fetal growth and development, complete penetrance J:197442
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Ptentm1Hwu/Ptentm1Hwu
Tg(Fabp1-cre)1Jig/0
involves: 129S2/SvPas * 129S4/SvJae * FVB/N
abnormal urinary bladder urothelium morphology J:106662
increased urinary bladder carcinoma incidence J:106662
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Rb1tm1Tyj/Rb1+
Tg(Rb1)1Blg/0
involves: 129S2/SvPas
abnormal xiphoid process morphology J:65679
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Rb1tm1Tyj/Rb1tm1Tyj
Tg(Rb1)1Blg/0
involves: 129S2/SvPas
abnormal deltoid tuberosity morphology J:65679
abnormal muscle physiology J:65679
abnormal myogenesis J:65679
abnormal posture J:65679
abnormal scapula morphology J:65679
abnormal skeletal muscle fiber morphology J:65679
abnormal sternocostal joint morphology J:65679
abnormal sternum ossification J:65679
abnormal xiphoid process morphology J:65679
absent deltoid tuberosity J:65679
decreased length of long bones J:65679
fragile skeleton J:65679
hemorrhage J:65679
hunched posture J:65679
polyploidy J:65679
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Tg(MMTV-vHaras)SH1Led/0
involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N
decreased tumor latency J:66183
enlarged Harderian gland J:66183
enlarged spleen J:66183
extramedullary hematopoiesis J:66183
Harderian gland hyperplasia J:66183
increased mammary adenocarcinoma incidence J:66183
increased salivary adenocarcinoma incidence J:66183
increased tumor incidence J:66183
Cdkn1atm1Tyj/Cdkn1atm1Tyj
Zfpm2tm1.1Esv/Zfpm2tm1.1Esv
involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
abnormal heart echocardiography feature J:216295
abnormal heart ventricle wall thickness J:216295
abnormal myocardium compact layer morphology J:216295
atrial septal defect J:216295
postnatal lethality, complete penetrance J:216295
ventricular septal defect J:216295

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/18/2022
MGI 6.17
The Jackson Laboratory