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Wrntm1Led
Targeted Allele Detail
Summary
Symbol: Wrntm1Led
Name: Werner syndrome RecQ like helicase; targeted mutation 1, Philip Leder
MGI ID: MGI:2156622
Synonyms: Wrndeltahel, WS
Gene: Wrn  Location: Chr8:33724412-33875555 bp, - strand  Genetic Position: Chr8, 20.3 cM, cytoband A4
Alliance: Wrntm1Led page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48424
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4 were replaced with a neomycin selection cassette. The targeted allele is expected to express a fully translated protein that lacks 121 amino acids of the helicase domain. (J:48424)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Wrntm1Led
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wrn Mutation:  91 strains or lines available
References
Original:  J:48424 Lebel M, et al., A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13097-102
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory